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Praziquantel CAS NO.55268-74-1

Min.Order Quantity:
1 Kilogram
Purity:
98%
Port:
China Main Ports
Payment Terms:
L/C,D/A,D/P,T/T,MoneyGram,Other

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Product Details

Keywords

  • Praziquantel
  • 55268-74-1
  • manufacturer , better price with good quality

Quick Details

  • ProName: Praziquantel
  • CasNo: 55268-74-1
  • Molecular Formula: C19H24N2O2
  • Appearance: White Solid
  • Application: Pharmaceuticals
  • DeliveryTime: Within 7 days
  • PackAge: Depended
  • Port: China Main Ports
  • ProductionCapacity: 300 Kilogram/Month
  • Purity: 98%
  • Storage: KEEP COLD
  • Transportation: BY SEA OR AIR
  • LimitNum: 1 Kilogram

Superiority


preview
cbnumber: cb8178956
chemical name: praziquantel
molecular formula: c19h24n2o2
formula weight: 312.41
cas no.: 55268-74-1
praziquantel basic information
the treatment of schistosomiasis chemical properties application production method category toxicity grading acute toxicity flammability and hazardous characteristics storage characteristics extinguishing agent
product name: praziquantel
synonyms: 1-a]-isoquinolin-4-one,2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4h-pyrazino-[2;2-cyclohexylcarbonyl-1,2,3,6,7,11b-hexahydro-4h-pyrazino(2,1-a)isoquinolin-4;4h-pyrazino(2,1-a)isoquinolin-4-one,2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexah;4h-pyrazino-[2,1-a]-isoquinolin-4-one,2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-;biltricide;droncit;embay8440;praz,quantel
cas: 55268-74-1
mf: c19h24n2o2
mw: 312.41
einecs: 259-559-6
product categories: pharmaceutical;api;cosmetic ingredients & chemicals;api's;aromatics;heterocycles;intermediates & fine chemicals;pharmaceuticals;biltricide;antiparasitic
mol file: 55268-74-1.mol
praziquantel structure
praziquantel chemical properties
mp 136-138 c
storage temp. −20°c
merck 13,7802
epa substance registry system 4h-pyrazino[2,1- a]isoquinolin-4-one, 2-(cyclohexylcarbonyl)-1,2, 3,6,7,11b-hexahydro-(55268-74-1)
safety information
hazard codes f,c
risk statements 11-34
safety statements 16-26-36/37/39-45
wgk germany 1
rtecs uq4150000
praziquantel usage and synthesis
the treatment of schistosomiasis schistosomiasis is parasitic disease with both human and animal being prone to get infected. schistosome has a relative complicated life history. adult parasites live in the mesenteric vein and portal vein blood of people, cattle, pigs and some other mammals, and therefore humans and these animals are called as the adult host or definitive host.
praziquantel is a kind of common drugs for treatment of schistosomiasis with an extremely small animal toxicity. after its oral administration, it is rapidly absorbed in the digestive tract. the time of the plasma concentration for reaching peaks: 5 minutes for mice, l5 ~ 30 minutes for rat, 30 to 120 minutes for dogs, and 2 h for sheep. after its absorption this drug is widely distributed in all tissues and organs; it is even able to penetrate through the blood-brain barrier of rats and can also enter into the bile of dogs. it can induce of influx of the ca 2+ located outside of the schistosome parasite muscle cell membrane, and thus causing muscle contractures and loss of ability of sucking parasite location. at the same time, it also causes deficiency in sugar metabolism and energy metabolism, disrupting the "with immunization" state and then working together with the host immune system for finally eliminating the parasites. therefore, it has good killing efficacy in treating china branch schistosomiasis, tapeworm, lung fluke, cysticercosis and also immature parasites (cercariae and miracidia).
the common side effects of praziquantel are as follows:
1. during the first 1 hour of medication of the first time: dizziness, headache, nausea, abdominal pain, diarrhea, fatigue, aching limbs can occur, usually at a lesser extent and short duration, and does not affect the treatment without specific treatment.
2. in a few cases, there may be symptoms such as heart palpitations, chest tightness, and t wave change and primary contraction in ecg; supraventricular tachycardia and atrial fibrillation can sometimes also happen.
3. in a few cases there may be a transient increase in transaminases and toxic hepatitis.
4. it sometimes can induce mental disorders and gastrointestinal bleeding.
5. hernia, allergic reactions (rash, asthma), etc. are also seen.
chemical properties it is white or almost white crystalline powder; it is odorless with a slightly bitter taste. it also has hygroscopic effect. solubility (g/100m1): 9.7 in ethanol, 56.7 in chloroform, and 0.04 in water. it is easily soluble in dimethyl sulfoxide (dmso), but insoluble in ether. it has a melting point of 136 ~ 141 ℃. acute toxicity ld50 in mice and rats (mg/kg): 2000 ~ 3000 oral administration,> 3,000 subcutaneously injection.
application it is a kind of broad-spectrum anti-parasitic disease drug. it can be used for the treatment and prevention of schistosomiasis, cysticercosis, paragonimiasis, hydatid disease, fasciolopsiasis, hydatid disease, and worm infection.
it can also be used as anthelmintic and is effective in treating animal gastrointestinal nematodes. it can be mixed in the feed for application.
the product is a kind of anthelmintic drug effective in treating schistosoma japonicum, schistosoma mansoni and schistosoma haematobium, clonorchis sinensis, paragonimus westermani, fasciolopsis buski, tapeworms and cysticercosis. it has a especially strong killing effect on tapeworm and is currently of highest efficiency among anti-schistosomiasis drug.
it is a kind of anthelmintics drug mainly used for treating schistosomiasis. it can also used for treating fahrenheit schistosomiasis, taeniasis, paragonimiasis, and cysticercosis
production method there are a variety of synthetic routes (isoquinoline route, piperazine route, and phenethylamine route). isoquinoline has advantages such as wide sources of initial raw material and low cost. isoquinoline can be converted to 1-benzoyl-2-cyano-1,2-dihydro-isoquinoline through reissetr reaction. it is further converted to 1-benzoyl-aminomethyl-1, 2, 3, 4-tetrahydroisoquinoline through pressurized hydrogenation. then followed by cyclization with chloroacetyl chloride to give 2-benzoyl-1,3, 4,6,7,11b-hexahydro-2h-pyrazino[2,1-b]isoquinolin-4-ketone. finally, apply phosphoric acid hydrolysis and perform condensation reaction with cyclohexanecarboxylic acid chloride to obtain the final product.
there are a variety of synthetic routes for industrial production including isoquinoline route, piperazine route, and phenethylamine route, among which the isoquinoline route is the best. in this route, first perform adduct reaction between isoquinoline and benzoyl chloride as well as potassium cyanide, further go through catalytic hydrogenation and rearrangement to generate 1-benzoyl-methyl-amino-1,2,3,4-tetrahydroisoquinoline, and then sequentially go through chlorine acetylation, cyclization, hydrolysis under increased pressure, and cyclohexanone acylation to generate the final product.
take phenethylamine as the raw material, after acylation through chloroacetyl chloride, further introduce the amino group after adding terephthalamide potassium for amination reaction, then have cyclization reaction in the action of phosphorus oxychloride to give 3,4-dihydroisoquinoline derivative; further go through hydrogenation and hydrolysis to obtain 1-aminomethyl-tetrahydroquinoline; successively use cyclohexane carboxylic acid chloride and chloroacetyl chloride for acylation and finally go through dehydrochlorination and cyclization to obtain praziquantel.
you can alternatively use isoquinoline as raw material; it first go through reissert reaction to introduce a cyano group in l position and have nitrogen benzoylated, followed by hydrogenation while benzoyl group is transferred to the amino group of the side chain, further introduce a chlorine acetyl group to the amino group on the ring, then successively go through cyclization, hydrolysis, cyclohexanone formylation to obtain praziquantel.
the above information is edited by the chemicalbook of dai xiongfeng.
category toxic substances
toxicity grading poisoning
acute toxicity oral rat ld50; 2840 mg / kg; oral - mouse ld50: 2454 mg / kg.
flammability and hazardous characteristics combustible; combustion produces toxic fumes of nitrogen oxides.
storage characteristics ventilation, low-temperature, and drying.
extinguishing agent dry powder, foam, sand, carbon dioxide, water spray.
chemical properties white solid
usage anthelmintic; embay-8440
usage anthelmintic, effective against flatworms.

Details

henan sunlake enterprise corporation is located in henan province, the central plain of china , which enjoys favorable geogeaphical position and convenient transportion. the comany was established in june 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .
sunlake is a professional manufacturer engaged in producing and selling chemicals,including organic & inorganic chemicals , pigments & dyestuffs , water treatment chemicals , food & feed additives and others . these products have been being well exported to europe , southeast asia , the middle east , africa , south america and some other countries and areas.
we sincerely welcome foreign friends to visit our plant for cooperation. with the idea of "quality first,credit priority, excellent service", we are highly acknowledged by customers for good quality and competitive price. more importantly , the company has a strong r & d team who are professional engineers and scholars with ph. d. .so we are confident to serve you better with our high - quality products and professional team.
we are taking great efforts to provide our customers with demanded goods and professional services, continuously improve our core ability of competition and get the momentum for sustainable development ,which finally makes us being a reliable and professional supplier in international market.
we welcome any inquiries from all customers of the world, and sincerely hope to cooperate with you for a brilliant future!
our advantages:
i). we have abundant professional production experience.
ii). we have our own chemical factory.
iii). sample is free of charge.
iv). reasonable price, excellent quality & attentive service
v). prompt reply: we can reply your inquiry and email within 24 hours.
vi). fast delivery: the delivery time is about 10-20 days after receiving the deposit.
vii). we have passed the lfgb, sgs, stc, hsl and some other tests.
viii). we have a unity cooperation team.
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