SIS3 CAS NO.521984-48-5

smad3 is a receptor-regulated intracellular protein that functions downstream of tgf-β and activin receptors and mediates their signaling, playing a role in cell proliferation, differentiation, apoptosis and formation of extracellular matrix. smad3 inhibitor, sis3 is a cell-permeable pyrrolopyridine compound that selectively inhibits tgf-β1-dependent smad3 phosphorylation and smad3-mediated cellular signaling with no effect on smad2, p38 mapk, erk, or pi 3-k signaling. it has been shown to reduce tgf-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.

tianjin kailiqi biopharma technology co., ltd, is a professional manufacturer specialized in the production and distribution of active pharmaceutical ingredients and intermediates. our company has strong r&d ability and production experience to provide the customers new apis. we specialize in developing innovative processes for the synthesis of a wide range of products. we also undertake custom synthesis and contract manufacturing.if you are interest in,pls contact with me,we also have lab,specifical in some hard synthesis.