TIANFU CHEM----A-83-01 CAS NO.909910-43-6

Min.Order Quantity:: 1 Kilogram

Purity:: 98

Port:: china mian port

Payment Terms:: L/C,T/T,MoneyGram

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Product Details

Keywords

A-83-01
909910-43-6
good quality

Quick Details

ProName: TIANFU CHEM----A-83-01
CasNo: 909910-43-6
Molecular Formula: C25H19N5S
Appearance: Colorless to light yellow liquid
Application: Water treatment
DeliveryTime: depends on yr quantity
PackAge: 20kg/drum, 200kg/drum or 1000kg/IBC Dr...
Port: china mian port
ProductionCapacity: 10 Metric Ton/Month
Purity: 98
Storage: Room temperature
Transportation: By sea , by air or express
LimitNum: 1 Kilogram
Grade: Industrial Grade,Electron Grade
Purity: 98% Min

Superiority

our company was built in 2009 with an iso certificate.in the past 5 years, we have grown up as a famous fine chemicals supplier in china and we had established stable business relationships with samsung,lg,merck,thermo fisher scientific and so on.our main business covers the fields below:

1.noble metal catalysts (pt.pd...)

2.organic phosphine ligands (tert-butyl-phosphine.cyclohexyl-phosphine...)

3.oled intermediates (fluorene,carbazole,boric acid...)

4.customs synthesis

our advantage:

1. higest quality and good package

2.fast delivery

3.better payment term

4.fast response to customer within 6 hours

5.good business credit in europe ,us ,japan ,korea

anyway ,if you need any chemicals from china ,henan tianfu can help you

Details

a-83-01 basic information

product name:	a-83-01
synonyms:	3-(6-methyl-2-pyridinyl)-n-phenyl-4-(4-quinolinyl)-1h-pyrazole-1-carbothioamide;a 83-01, >=98%;tgf inhibitor a-83-01;3-(6-methylpyridin-2-yl)-n-phenyl-4-(quinolin-4-yl)-1h-pyrazole-1-carbothioamide
cas:	909910-43-6
mf:	c25h19n5s
mw:	421.526
einecs:
product categories:	protein kinase;tgf-beta/smad;inhibitors
mol file:	909910-43-6.mol

a-83-01 chemical properties

mp	111℃
storage temp.	store at -20°c

safety information

hazard codes	xn
risk statements	22-36/37/38
safety statements	26-36

msds information

a-83-01 usage and synthesis

usage

a 83-01 is a selective inhibitor of tgf-β type i receptor. a 83-01 treatment increases tumor permeability.

biological activity

selective inhibitor of tgf- β type i receptor alk5 kinase, type i activin/nodal receptor alk4 and type i nodal receptor alk7 (ic 50 values are 12, 45 and 7.5 nm respectively). blocks phosphorylation of smad2 and inhibits tgf- β -induced epithelial-to-mesenchymal transition. only weakly inhibits alk-1, -2, -3, -6 and mapk activity. more potent than sb 431542 (4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1h-imidazol -2-yl]benzamide). inhibits differentiation of rat induced pluripotent stem cells (ripscs) and increases clonal expansion efficiency. helps maintain homogeneity and long-term in vitro self-renewal of human ipscs.

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