TIANFU-CHEM - Sitafloxacin CAS NO.127254-12-0

sitafloxacin basic information

description references

product name: sitafloxacin

synonyms: sitafloxacin;spifloxacin;7-[(4s)-4-amino-6-azaspiro[2.4]heptan-6-yl]-8-chloro-6-fluoro-1-[(2s)-2-fluorocyclopropyl]-4-oxoquinoline-3-carboxylic acid;3-quinolinecarboxylic acid, 7-[(7s)-7-amino-5-azaspiro[2.4]hept-5-yl]-8-chloro-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-;sitafloxacin anhydrous;7-((s)-7-amino-5-azaspiro[2.4]heptan-5-yl)-8-chloro-6-fluoro-1-((1r,2s)-2-fluorocyclopropyl)-4

cas: 127254-12-0

mf: c19h18clf2n3o3

mw: 409.81

einecs:

product categories:

mol file: 127254-12-0.mol

sitafloxacin structure

sitafloxacin chemical properties

cas database reference 127254-12-0(cas database reference)

safety information

msds information

sitafloxacin usage and synthesis

description sitafloxacin (trade name: gracevit in japan) belongs to a new generation, broad-spectrum oral fluoroquinolone antibiotics. it is highly active against various kinds of gram-negative, gram-positive and anaerobic clinical isolates, even including strains that are resistant to other kinds of fluoroquinolone antibiotics. it has been listed in japan for the treatment of respiratory and urinary tract infections. it also shows potential for the treatment of buruli ulcer. its mechanism of action is through inhibiting the topoisomerase ii ligase domain of bacteria, causing dna fragmentation to inhibit the dna synthesis of bacteria.

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sitafloxacin preparation products and raw materials