Henan Tianfu Chemical Co., Ltd.
Country: China (Mainland)
Year Established: 2006
Business License:
Business type: Lab/Research institutions
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TIANFU-CHEM - Sitagliptin phosphate CAS NO.654671-78-0

FOB Price:: USD 1,000.00-1,000.00 /Gram Get Latest Price

Min.Order Quantity:: 1 Gram

Purity:: 99.0%

Port:: SHANGHAI

Payment Terms:: L/C,D/A,D/P,T/T,MoneyGram,Other

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Product Details

Keywords

Sitagliptin phosphate
654671-78-0
C16H15F6N5O.H3PO4

Quick Details

ProName: TIANFU-CHEM - Sitagliptin phosphate
CasNo: 654671-78-0
Molecular Formula: C16H15F6N5O.H3PO4
Appearance: Solid
Application: Organic synthesis
DeliveryTime: PROMPT
PackAge: IN 25kg drums
Port: SHANGHAI
ProductionCapacity: 10 Metric Ton/Month
Purity: 99.0%
Storage: In Room Temperature
Transportation: As per MSDS
LimitNum: 1 Gram
Heavy metal: N/A
Grade: Industrial Grade,Food Grade,Pharma Gra...

Superiority

henan tianfu chemical co., ltd. is located in zhengzhou high-tech development zone with import and export license.

we passed iso 9001:2008 in 2009, and won "high-tech enterprise" by provincial government in 2013.the objective of the company is to put quality first and put our customer’s needs first - the satisfaction of our customers is the company's ultimate goal.

improving product quality and service level is our responsibility, and creating more value for our customer’s is our purpose. we are constantly striving to make henan tianfu a leading chemical supplier, and hope to create a better future with you.

Details

sitagliptin phosphate basic information

new antidiabetic drug dpp-4 inhibitors

product name: sitagliptin phosphate

synonyms: (3r)-3-amino-1-[3-(trifluoromethyl)-5h,6h,7h,8h-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;sitagliptin phosphate/sitagliptin phosphate monohydrate/sitagliptin;sitagliptin phosphate 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo[4,3-a]pyrazin-7(8h)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine phosphate;3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]-pyrazin-7(8h)-yl)-4-(2,4,5-t;sitagpliptin;4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo[4,3-a]pyrazin-7(8h)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine phosphate;sitagliptin phosphate;7-[(3r)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-α]pyrazine-phosphate

cas: 654671-78-0

mf: c16h15f6n5o.h3po4

mw: 505.31

einecs:

product categories: pharmaceutical intermdiate;all inhibitors;inhibitors;intermediates & fine chemicals;pharmaceuticals;api

mol file: 654671-78-0.mol

sitagliptin phosphate structure

sitagliptin phosphate chemical properties

melting point 202-204°c

storage temp. -20°c freezer

safety information

msds information

sitagliptin phosphate usage and synthesis

new antidiabetic drug sitagliptin phosphate is dipeptidyl peptidase ⅳ(ddp-4) inhibitor class of drugs developed by the german merck company and firstly obtained the us food and drug administration approval for the treatment of type 2 diabetes, is a new antidiabetic drug, can improve the body's own ability to reduce high blood glucose levels, and the relatively increase naturally occurring incretin by inhibiting the activity of this enzyme, including the levels of glucagon-like peptide 1 and glucose-dependent insulinotropic peptide, thereby triggering the pancreas to improve insulin production and stop glucose production in liver, and ultimately reduce the clinical effect of blood glucose concentration. features of this product is to stimulate insulin secretion, at the same time can alleviate hunger, but does not make weight gain, and also cannot happen hypoglycemia and edema, is not suitable for use in diabetic patients with poor glycemic control and often developed hypoglycemia. by verification of clinical 552 cases of mild to moderate type 2 diabetes, taken once a day sitagliptin phosphate, once time 100 mg, after taking the drug for 12 weeks, can make glycated hemoglobin reduce 0.6%-1.1%. incidence of adverse reactions is similar to placebo, the most frequently reported adverse reactions (incidence> 5% and greater than placebo) is a stuffy or runny nose, and sore throat, upper respiratory tract infection and headache.

clinical studies showed that the sitagliptin phosphate as monotherapy in patients with type 2 diabetes, can make glycated hemoglobin (hba1c) levels significantly reduce. when in combination with the metformin or tzds, has a significant role of adjuvant therapy, can focus on three kinds of major defect in type 2 diabetes: insulin resistance, β-cell dysfunction (reduction of insulin release), and α-cell dysfunction (unsuppressed hepatic glucose generation) plays a role. but the drug should not be used for treatment of patients with type 1 diabetes or diabetic ketoacidosis.

the above information is edited by the chemicalbook of liu yujie.

dpp-4 inhibitors sitagliptin phosphate (trade name januvia) is the dpp-4 inhibitor first clinically approved for the treatment of type 2 diabetes, developed by germany company merck, and was listed in 2006 in mexico and the united states in 2007, also obtained eu approval for the treatment of type 2 diabetes. china approval was soon, currently sitagliptin phosphate tablets has become the second largest drug of oral diabetes drugs in us.

sitagliptin phosphate can enhance a called incretin system of human physiological system, resulting in physiological hypoglycemic effect. this physiological system itself can affect β cells and α cells of the islet, help to regulate glucose, and insulin reduction only caused by β-cell dysfunction can cause the increase of blood glucose, or because cells α and β-cell dysfunction cause loss of control in hepatic glucose synthesis and thus lead to elevated blood glucose, dpp-4 will produce efficacy.

sitagliptin phosphate exists dependent of glucose levels, it will not only know hypoglycemic blindly, not predatorily press islet, exhaust the pancreas function. in contrast, the test proved that it has the prospect of long-term protection of human β cells. in addition, it does not lead to side effects such as weight gain, decreased blood glucose, medication compliance of patient will be greatly enhanced. therefore, in theory it's effective role in life will greatly exceed the current oral antidiabetic drug, insulin dependent of patients will be greatly delayed.

chemical properties white solid

uses a trizolopyrazine dipeptidyl peptidase iv inhibitor. it has recently been approved for the therapy of type ii diabetes.

uses sitagliptin is a trizolopyrazine dipeptidyl peptidase iv inhibitor. sitagliptin has recently been approved for the therapy of type ii diabetes.

sitagliptin phosphate preparation products and raw materials