product name: fasudil
synonyms: fasudil;1-(5-isoquinoline-sulfonyl)-homopiperazine;at877;hexahydro-1-(5-isoquinolinylsulfonyl)-1h-4-diazepine;ha-1077 dihydrochloride novel vasodilato r age;ha 1077, dihydrochloride, 99+%;hexahydro-1-(5-isoquinolinylsulfonyl)-1h-1,4-diazepine;ha-1077:eril
cas: 103745-39-7
mf: c14h17n3o2s
mw: 291.37
einecs:
product categories: protein kinase inhibitors and activators;protein kinase;signalling;angiogenesis and metastasis;intracellular signaling;apis;eril;fasudil ada@tuskwei.com sky;18031153937@189.cn;glutaraldehyde ada@tuskwei.com whatsapp;8618031153937
mol file: 103745-39-7.mol
fasudil structure
fasudil chemical properties
storage temp. store at rt
solubility h2o: >200 mg/ml
form solid
color white
water solubility soluble in water or dmso
cas database reference 103745-39-7(cas database reference)
safety information
wgk germany 3
rtecs hm4031166
msds information
fasudil usage and synthesis
chemical properties white crystalline solid
uses vasodilator (cerebral), ca antagonist
uses a potent calcium antagonist vasodilator which is considered to act by employing different mechanisms from the usual calcium channel blockers since it inhibits (1) calcium ionophore a23187 induced co ntraction in arterial strips and (2) phenylephrine induced contraction in calcium free media suggesting that its site of action is in the intracellular space. also reported to potently inhibit rho- associated kinase (rock ic50= 10.7 um).
biological activity cyclic nucleotide-dependent protein kinase inhibitor and rho-associated kinase inhibitor (ic50 = 10.7 μm). ca2+ antagonist and vasodilator. also inhibits proliferation of vascular smooth muscle cells.