China (Mainland) 
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tacrolimus cas no.: 104987-11-3 synonyms: formula: c44h69no12 exact mass: 803.48200 molecular weight: 804.01800 psa: 178.36000 logp: 4.57690 -
tacrolimus usage and synthesis chemical properties white crystalline solid usage an immunosuppressant that blocks t cell proliferation in vitro by inhibiting the generation of several lymphokines, especially il-2. shown to inhibit the activity of fk-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum ca+2 release. usage fk-506 (tacrolimus) is a macrolide immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system usage tacrolimus (fujimycin) was discovered as a potent inhibitor of il2 production in a targeted search for novel immunosuppressants. tacrolimus acts by blocking t cell proliferation in vitro by inhibiting the generation of several lymphokines, notably the original target il-2. tacrolimus inhibits the activity of fk-506 binding protein, ca2+-dependent phosphatase and calcineurin, and activates nf-κb through phosphorylation and degradation of iκbα. usage treatment of cushing's syndrome usage for use after allogenic organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. it was first approved by the fda in 1994 for use in liver transplantation, this has been extended to include kidney, heart,
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propertiefeedback
appearance & physical state: white or off-white crystalline powder density: 1.19 g/cm3 melting point: 113-115ºc boiling point: 871.7ºc at 760 mmhg flash point: 481ºc refractive index: 1.549 storage condition: -20ºc vapor pressure: 1.73e-35mmhg at 25°c
safety infofeedbackrtecs: kd4201200 safety statements: s45-s36-s26 wgk germany: 3 ridadr: un 2811 6 risk statements: r25; r36/37/38 hazard codes: xi; t