Tacrolimus CAS NO.104987-11-3

Min.Order Quantity:: 1 Kilogram

Purity:: 98%min

Port:: shanghai

Payment Terms:: L/C,D/A,D/P,T/T,

Add to Inquiry Cart

Product Details

Keywords

104987-11-3
Tacrolimus
C44H69NO12

Quick Details

ProName: Tacrolimus
CasNo: 104987-11-3
Molecular Formula: C44H69NO12
Appearance: white powder
Application: diagnostic reagent
DeliveryTime: 20day
PackAge: meet the demand of customer
Port: shanghai
ProductionCapacity: 20 Metric Ton/Month
Purity: 98%min
Storage: cold storage
Transportation: by sea or by air
LimitNum: 1 Kilogram

Superiority

t he company has advanced technology, as well as a large number of excellent r & d team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality service

Details

located in zhengdong new district, zhengzhou of henan province, henan allgreen chemical co.,ltd is comprehensive high-tech modern enterprises integrating professional r&d, production and sales. strong technical force, with a long-term professional development team engaging in the fine chemicals, henan allgreen chemical co.,ltd is mainly engaged in development and customized of organic electronic chemical materials, metal catalysts, phosphorus ligands, medical intermediate , chemical reagent and other fine chemical products.we have multifunctional production conditions and could offer high quality products from grams to kilograms and tons. in addition, we absorb new technology actively from colleges and also have established good relations of cooperation with huazhong university of science and technology ,henan institute of engineering and some other well-known domestic enterprises. our products have been exported to japan, south korea, europe, america and other countries and regions, well received by customers.

with sound management system, we've been authorized the import&export qualification by the government and also has passed the “iso 9001-2008 quality management system” certification. we always stand on the quality of product as our life, develop in the direction of customers requirement and aim at creating greater value for customers.innovation and honesty, we will make common development with the masses of customers at home and abroad hand in hand by our best service.

tacrolimus basic information

product name:	tacrolimus
synonyms:	(2-propenyl)-,(3s-(3r(e(1s,3s,4s)),4s,5r,8s,9e,12r,14r,15s,16r,18s;,19s,26ar))-;16-dimethoxy-4,10,12,18-tetramethyl-8-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1;19-epoxy-3h-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4h,23h)-tetrone,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-14,16-dim;6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-5;fr900506;prograf;tsukubaenolide
cas:	104987-11-3
mf:	c44h69no12
mw:	804.02
einecs:
product categories:	active pharmaceutical ingredients;immunosuppressant.;intermediates & fine chemicals;pharmaceuticals;api;chiral reagents;fujimycin, prograf;antibiotic
mol file:	104987-11-3.mol

tacrolimus chemical properties

mp	113-115°c
storage temp.	−20°c
solubility	dmso: >3 mg/ml
form	solid
color	white
cas database reference	104987-11-3(cas database reference)

safety information

hazard codes	t,xi,xn,f
risk statements	25-36/37/38-36-20/21/22-11
safety statements	45-36-26-36/37-16
ridadr	un 2811 6.1/pg 3
wgk germany	3
rtecs	kd4201200

msds information

tacrolimus usage and synthesis

chemical properties	white crystalline solid
usage	an immunosuppressant that blocks t cell proliferation in vitro by inhibiting the generation of several lymphokines, especially il-2. shown to inhibit the activity of fk-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum ca+2 release.
usage	fk-506 (tacrolimus) is a macrolide immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system
usage	tacrolimus (fujimycin) was discovered as a potent inhibitor of il2 production in a targeted search for novel immunosuppressants. tacrolimus acts by blocking t cell proliferation in vitro by inhibiting the generation of several lymphokines, notably the original target il-2. tacrolimus inhibits the activity of fk-506 binding protein, ca2+-dependent phosphatase and calcineurin, and activates nf-κb through phosphorylation and degradation of iκbα.
usage	treatment of cushing's syndrome
usage	for use after allogenic organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. it was first approved by the fda in 1994 for use in liver transplantation, this has been extended to include kidney, heart,