Theophylline Pharmaceutical raw materials CAS NO.58-55-9

theophylline

alias: theophylline; anhydrous theophylline; 1,3-dimethyl-3,7-dihydro-1h-purine-2,6-dione; dioxydimethylpurine; 1,3-dimethyl xanthine; hydrated tea leaves;

english name: theophylline

cas no.: 58-55-9

einecs number: 200-385-7

molecular formula: c7h10n4o2

molecular weight: 182.1799

density: 1.62g / cm3

melting point: 270-274 ° c

boiling point: 390.1 ° c at 760 mmhg

flash point: 189.7 ° c

water solubility: 8.3 g / l (20 ° c)

vapor pressure: 2.72e-06mmhg at 25 ° c

solubility: 0.1 m hcl: soluble

water solubility: 8.3 g / l (20 ° c)

storage conditions: 2-8 ° c

solubility: soluble in water at room temperature (1: 120), ethanol (1:18), chloroform (1: 86), hydrochloric acid, ammonia, dilute hydrochloric acid and dilute nitric acid.

chemical properties

white crystalline or crystalline powder, odorless, bitter taste. mp270-274 ° c. at room temperature in water (1: 120), ethanol (1:18), chloroform (1: 86), hydrochloric acid, ammonia, dilute hydrochloric acid and dilute nitric acid, slightly soluble in ether. medium toxicity, ld50 (rat, oral) 300mg / kg.

use

biochemical research, pharmaceutical synthesis intermediates.

use

methyl purine drugs. with cardiac, diuretic, dilated coronary artery, relaxation of bronchial smooth muscle and excitement of the central system by the role. mainly used for the treatment of bronchial asthma, emphysema, bronchitis, cardiac dyspnea.

use

used as a pharmaceutical intermediate

use

mainly for the treatment of bronchial and cardiac asthma, can also be used for cardiogenic edema

production method

1,3-dimethyl-4-amino-5-carboxamide urea and lithium hydroxide solution at 90-95 ° c reaction, theophylline crude, the hot water recrystallization, activated carbon decolorization was finished.

production method

ethyl cyanoacetate and dimethyl urea as raw materials, by condensation, nitrosation, reduction, formylation, cyclization in the crude product, and then recrystallization derived.

hubei manufacturers factory direct stock supply inexpensive

kg 99% powder white 25 / cardboard drum