Tubastatin A CAS NO.1252003-15-8

tubastatin a is a potent and selective hdac6 inhibitor. demonstrates 1093-fold selectivity over hdac1 (ic50 values of 15 nm for hdac6 vs 16.4 âµm for hdac1). tubastatin a was substantially more selective than the known hdac6 inhibitor tubacin at all isozymes except hdac8. tubastatin a is a potent hdac6 inhibitor with an ic50 value of 15 nm. comparatively, it demonstrates over 1,000-fold selectivity against all other hdac isoforms (ic50 >16 μm), excluding hdac8 (ic50= 0.9 μm). tubastatin a induces α-tubulin hyperacetylation at 2.5 μm in primary cortical neuron cultures. in a model of oxidative stress induced by glutathione depletion, tubastatin a displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μm.

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