Voriconazole 137234-62-9 Large in supply CAS NO.137234-62-9

Min.Order Quantity:: 1 Kilogram

Purity:: 99%

Port:: Shanghai

Payment Terms:: T/T,MoneyGram,Other

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Product Details

Keywords

137234-62-9
Voriconazole
Voriconazole≥ 99.9% (HPLC, Dried basis)

Quick Details

ProName: Voriconazole 137234-62-9 Large in supp...
CasNo: 137234-62-9
Molecular Formula: C16H14F3N5O
Appearance: powder
Application: broad-spectrum antifungal
DeliveryTime: in stock
PackAge: drums
Port: Shanghai
ProductionCapacity: 100 Kilogram/Month
Purity: 99%
Storage: dry and cool
Transportation: air, courier and sea
LimitNum: 1 Kilogram

Superiority

synonyms: voriconazole 2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1h-1,2,4-triazol-1-yl)butan-2-ol;voriconazole solution;(2r,3s)-2-(2,4-difluorophenyl)-3;2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1,2,4-triazol-1-yl)butan-2-ol;2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol;voriconazole, >=98.5%;(2r,3s)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-((1h)-1,2,4-triazol-1-yl)-butan-2-;voriconazole≥ 99.9% (hplc, dried basis)
cas: 137234-62-9
mf: c16h14f3n5o
mw: 349.31
einecs: 200-261-5
product categories: fine chemical;antifungal;api;antifungal (systemic);inhibitors;intermediates & fine chemicals;pharmaceuticals;aromatics;heterocycles;pfizer compounds;inhibitor;zinacef
mol file: 137234-62-9.mol
voriconazole structure
voriconazole chemical properties
melting point 127-130°c
fp 9℃
storage temp. store at +4°c
solubility dmso: >20mg/ml
cas database reference 137234-62-9(cas database reference)
safety information
hazard codes xn,t,f
risk statements 22-36/38-52/53-48/22-40-25-61-39/23/24/25-23/24/25-11
safety statements 26-36-45-36/37-22-53-16
ridadr un1230 - class 3 - pg 2 - methanol, solution
rtecs uv9145000

Details

voriconazole usage and synthesis
product description voriconazole is a broad-spectrum triazole antifungal ,it is primarily used for the treatment of progressive, possibly life-threatening infections in immune deficiency patients. indications include: immunosuppressed patients with severe fungal infections, acute invasive aspergillosis (the most common pathogen is aspergillus fumigatus, followed by a. flavus, aspergillus niger and aspergillus soil), severe invasive infections caused by fluconazole-resistant candida (including c. krusei) severe infection caused by foot actinomycetes bacteria genus and fusarium bacteria genus . moderate to severe renal insufficiency is administered intravenously paying caution.
pharmacological interactions combination with the cyp3a4 substrates, terfenadine, sirolimus, astemizole, cisapride, pimozide or quinidine , can increase blood concentrations of this drug, leading to qt prolongation, and occasionally torsades de pointes ventricular tachycardia.
combination with rifampicin, rifabutin, efavirenz, ritonavir (each 400mg, once every 12 hours), carbamazepine and phenobarbital, can significantly lower blood concentrations of voriconazole.
combination with ergot alkaloids (ergotamine, dihydroergotamine) plasma concentrations of ergot drugs can cause increased ergot poisoning.
the above information is edited by the chemicalbook of tian ye.
uses broad-spectrum antifungal
chemical properties cyrstalline solid
uses an antifungal (systemic). an ergosterol biosynthesis inhibitor.
uses antibacterial
uses an antifungal. an ergosterol biosynthesis inhibitor
definition chebi: a triazole-based antifungal agent used for the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by scedosporium apiospermum and fusarium spp. it is an inhibitor of cytochr me p450 2c9 (cyp2c9) and cyp3a4.
biological activity triazole antifungal agent. displays potent activity against candida , cryptococcus and aspergillus species.