amisulpride 71675-85-9 CAS NO.71675-85-9

【biological activity]

potent, selective dopamine d 2 and d 3 receptor antagonist. k i values are 2.8 and 3.2 nm respectively for human d 2 and d 3 and > 1000 nm for human d 1 , d 4 and d 5 receptors. shows selectivity for presynaptic dopamine autoreceptors at low doses and blocks postsynaptic d 2 /d 3 receptors at higher doses. preferentially interacts with limbic d 2 -like receptors in vivo . atypical antipsychotic/antischizophrenic agent with limited extrapyrimidal side effects and a profile distinct from that of haloperidol and remoxipride.

【therapeutic uses]

neuroleptic agent, an analogue of sulpiride. used as an antipsychotic. dopamine receptor antagonist

【biomedical effects and toxicity]

potent, selective dopamine d 2 and d 3 receptor antagonist. k i values are 2.8 and 3.2 nm respectively for human d 2 and d 3 and > 1000 nm for human d 1 , d 4 and d 5 receptors. shows selectivity for presynaptic dopamine autoreceptors at low doses and blocks postsynaptic d 2 /d 3 receptors at higher doses. preferentially interacts with limbic d 2 -like receptors in vivo . atypical antipsychotic/antischizophrenic agent with limited extrapyrimidal side effects and a profile distinct from that of haloperidol and remoxipride.