Effects of long-term administration of ambenonium chloride (cas 115-79-7) on motor end-plate fine structure and acetylcholine receptor in rat☆
-
Add time:08/24/2019 Source:sciencedirect.com
ambenonium chloride (cas 115-79-7) was administered orally in a dosage of 6 mg/kg/day to rats for 14–360 days.Motor end-plate fine structure and junctional AChR were quantitatively analyzed in red (soleus) and white (EDL) muscle fibers. In treated animals, degeneration and simplification of postsynaptic folds and widening of synaptic clefts were often observed in soleus end-plates, but infrequently in EDL end-plates. On the other hand, the postsynaptic AChR was reduced markedly in both soleus and EDL end-plates. No presynaptic changes were observed.These results show that long-term administration of Anti-ChE agents in myasthenia gravis may have an adverse effect on neuromuscular transmission.
We also recommend Trading Suppliers and Manufacturers of ambenonium chloride (cas 115-79-7). Pls Click Website Link as below: cas 115-79-7 suppliers
Prev:Design, synthesis and biological evaluation of ambenonium derivatives as AChE inhibitors
Next:Sensitive determination of ambenonium chloride (cas 115-79-7) in serum from patients with myasthenia gravis using ion-exchange resin extraction and reversed-phase ion-pair chromatography) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Sensitive determination of ambenonium chloride (cas 115-79-7) in serum from patients with myasthenia gravis using ion-exchange resin extraction and reversed-phase ion-pair chromatography08/25/2019
- Design, synthesis and biological evaluation of ambenonium derivatives as AChE inhibitors08/23/2019
- Fine structural analysis of the localization of acetylcholinesterase accessible to intraventricular ambenonium chloride (cas 115-79-7) in rabbit brain08/22/2019