Trypanosoma cruzi: trypanocidal effect of 2(3)-tert-butyl-4-hydroxyanisole (BHA) on several strains of epimastigote and trypomastigote forms
-
Add time:08/31/2019 Source:sciencedirect.com
BHA (2(3)-tert-butyl-4-hydroxyanisole) produced inhibition of both culture growth and oxygen consumption, NAD(P) reduction and cytochrome b oxidation, on intact epimastigotes of Trypanosoma cruzi. BHA inhibited respiration and reduced NAD(P) in intact T. cruzi trypomastigotes. Oxidative phosphorylation of in situ mitochondria of epimastigotes was inhibited by BHA and this effect was liberated by the addition of ascorbate + TMPD. The incorporation of rhodamine-123 to mitochondria of living epimastigotes was diminished by BHA. These results suggest that the basis of the trypanocidal effects of BHA could be due to the blockage of the mitochondrial electron transport chain on the segment previous to cytochrome c. We postulate that the mechanism of action of BHA could be by mimicking coenzyme-Q (ubiquinone).
We also recommend Trading Suppliers and Manufacturers of 3-TERT-BUTYL-4-HYDROXYANISOLE (cas 121-00-6). Pls Click Website Link as below: cas 121-00-6 suppliers
Prev:Metabolism of 2- and 3-TERT-BUTYL-4-HYDROXYANISOLE (cas 121-00-6) in the rat (III): Metabolites in the urine and feces
Next:Protective effects of 2(3)-tert-butyl-4-hydroxyanisole on chemical carcinogenesis) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Promoting activity of 3-TERT-BUTYL-4-HYDROXYANISOLE (cas 121-00-6) (BHA) in BALB/3T3 cell transformation09/06/2019
- Mutagenicity of 3-TERT-BUTYL-4-HYDROXYANISOLE (cas 121-00-6) (BHA) and its metabolites in short-term tests in vitro09/05/2019
- Voltammetric determination of the phenolic antioxidants 3-TERT-BUTYL-4-HYDROXYANISOLE (cas 121-00-6) and tert-butylhydroquinone at a polypyrrole electrode modified with a nickel phthalocyanine complex09/04/2019
- Metabolism of 2- and 3-TERT-BUTYL-4-HYDROXYANISOLE (cas 121-00-6) (2- and 3-BHA) in the rat (II): Metabolism in forestomach and covalent binding to tissue macromolecules09/03/2019
- Short paperKinetics of 3-TERT-BUTYL-4-HYDROXYANISOLE (cas 121-00-6) (BHA) in man09/02/2019
- Protective effects of 2(3)-tert-butyl-4-hydroxyanisole on chemical carcinogenesis09/01/2019
- Metabolism of 2- and 3-TERT-BUTYL-4-HYDROXYANISOLE (cas 121-00-6) in the rat (III): Metabolites in the urine and feces08/30/2019
- Conformational stability, vibrational and NMR analysis, chemical potential and thermodynamical parameter of 3-TERT-BUTYL-4-HYDROXYANISOLE (cas 121-00-6)08/29/2019
- Analytical MethodsSimultaneous analysis of tert-butylhydroquinone, tert-butylquinone, butylated hydroxytoluene, 2-tert-butyl-4-hydroxyanisole, 3-TERT-BUTYL-4-HYDROXYANISOLE (cas 121-00-6), α-tocopherol, γ-tocopherol, and δ-tocopherol in edible oils by normal-phase high performance liquid chromatography08/28/2019