ArticleMaternal NICOTINAMIDE RIBOSIDE (cas 1341-23-7) Enhances Postpartum Weight Loss, Juvenile Offspring Development, and Neurogenesis of Adult Offspring
-
Add time:09/06/2019 Source:sciencedirect.com
SummaryConditions of metabolic stress dysregulate the NAD metabolome. By restoring NAD, NICOTINAMIDE RIBOSIDE (cas 1341-23-7) (NR) provides resistance to such conditions. We tested the hypotheses that postpartum might dysregulate maternal NAD and that increasing systemic NAD with NR might benefit mothers and offspring. In postpartum mothers, the liver NAD metabolome is depressed while blood increases circulation of NAD metabolites to enable a >20-fold increase in mammary NAD+ and NADP+. Lactation and NR synergize in stimulating prolactin synthesis and mammary biosynthetic programs. NR supplementation of new mothers increases lactation and nursing behaviors and stimulates maternal transmission of macronutrients, micronutrients, and BDNF into milk. Pups of NR-supplemented mothers are advantaged in glycemic control, size at weaning, and synaptic pruning. Adult offspring of mothers supplemented during nursing retain advantages in physical performance, anti-anxiety, spatial memory, delayed onset of behavioral immobility, and promotion of adult hippocampal neurogenesis. Thus, postgestational maternal micronutrition confers lasting advantages to offspring.
We also recommend Trading Suppliers and Manufacturers of NICOTINAMIDE RIBOSIDE (cas 1341-23-7). Pls Click Website Link as below: cas 1341-23-7 suppliers
Prev:ArticleThe NAD-Booster NICOTINAMIDE RIBOSIDE (cas 1341-23-7) Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance
Next:Research paperNICOTINAMIDE RIBOSIDE (cas 1341-23-7) attenuates alcohol induced liver injuries via activation of SirT1/PGC-1α/mitochondrial biosynthesis pathway) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- ArticleThe NAD+ Precursor NICOTINAMIDE RIBOSIDE (cas 1341-23-7) Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson’s Disease09/08/2019
- Research paperNICOTINAMIDE RIBOSIDE (cas 1341-23-7) attenuates alcohol induced liver injuries via activation of SirT1/PGC-1α/mitochondrial biosynthesis pathway09/07/2019
- ArticleThe NAD-Booster NICOTINAMIDE RIBOSIDE (cas 1341-23-7) Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance09/05/2019
- NICOTINAMIDE RIBOSIDE (cas 1341-23-7) protects against liver fibrosis induced by CCl4 via regulating the acetylation of Smads signaling pathway09/04/2019
- NICOTINAMIDE RIBOSIDE (cas 1341-23-7) induces a thermogenic response in lean mice09/03/2019
- Analytical MethodsSimultaneous quantitation of NICOTINAMIDE RIBOSIDE (cas 1341-23-7), nicotinamide mononucleotide and nicotinamide adenine dinucleotide in milk by a novel enzyme-coupled assay09/02/2019
- Original ArticleNICOTINAMIDE RIBOSIDE (cas 1341-23-7) kinases display redundancy in mediating nicotinamide mononucleotide and NICOTINAMIDE RIBOSIDE (cas 1341-23-7) metabolism in skeletal muscle cells09/01/2019
- Original articleAdministration of NICOTINAMIDE RIBOSIDE (cas 1341-23-7) prevents oxidative stress and organ injury in sepsis08/31/2019
- NICOTINAMIDE RIBOSIDE (cas 1341-23-7), an NAD+ precursor, attenuates the development of liver fibrosis in a diet-induced mouse model of liver fibrosis08/30/2019
-
Health and Chemical more >