The isolation and identification of 2-methyl-2,4-thiazolidine dicarboxylate (cas 16708-09-1) as a by-product in the conversion of cysteine to glucose in the perfused rat liver
-
Add time:09/06/2019 Source:sciencedirect.com
Cysteine is one of the more toxic amino acids, however the toxic agent associated with cysteine toxicity has not been identified. Recently it was shown that 2-methyl-2,4-thiazolidine dicarboxylate (cas 16708-09-1) (MTD) was formed from cysteine by rat liver and would be toxic to the rat. This suggested that MTD formed by the rat liver can be produced both enzymatically and by chemical interaction between cysteine and another compound, possibly pyruvate. When MTD (1 mmol/rat) was injected into 6 rats, two of them died. Only 70–80% of the MTD was excreted within 24 h, suggesting an accumulation of MTD. It is possible that MTD could accumulate in the tissues until it reahed a toxic concentration. Whether this could account for the death associated with cysteine toxicity is unknown.
We also recommend Trading Suppliers and Manufacturers of 2-methyl-2,4-thiazolidine dicarboxylate (cas 16708-09-1). Pls Click Website Link as below: cas 16708-09-1 suppliers
Prev:Thiol containing compounds and amino acid hydroxamates as reversible synthetic inhibitors of Astacus protease☆
Next:Original articleSynthesis and biological evaluation of novel dimethyl[1,1′-biphenyl]-2,2′-dicarboxylate derivatives containing thiazolidine-2,4-dione for the treatment of concanavalin A-induced acute liver injury of BALB/c mice) - 【Back】【Close 】【Print】【Add to favorite 】