Synthesis of IMPERATORIN (cas 148-83-4) Analogs and Their Evaluation as Acetylcholinesterase and Butyrylcholinesterase Inhibitors
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Add time:09/29/2019 Source:infona.pl
In this study, we synthesized several IMPERATORIN (cas 148-83-4) analogs using imperatorin and xanthotoxin as substrates. The anti‐cholinesterase activities of all compounds were evaluated in in vitro experiments according to the modified Ellman's method. For each synthesized compound, IC50 values for both enzymes were established. Galantamine hydrobromide was used as a positive control in the enzymatic experiments. All active compounds showed selectivity toward butyrylcholinesterase (BuChE) rather than acetylcholinesterase. The most active ones were 8‐(3‐methylbutoxy)‐psoralen and 8‐hexoxypsoralen with IC50 values for BuChE of around 16.5 and 16.4 µM, respectively. The results of our study may be considered as the beginning of a search for potential anti‐Alzheimer's disease drugs based on the structure of natural furocoumarins.
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Next:Simultaneous determination of scopoletin, psoralen, bergapten, xanthotoxin, columbianetin acetate, IMPERATORIN (cas 148-83-4), osthole and isoIMPERATORIN (cas 148-83-4) in rat plasma by LC–MS/MS for pharmacokinetic studies following oral administration of Radix Angelicae Pubescentis extract) - 【Back】【Close 】【Print】【Add to favorite 】
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- Simultaneous determination of scopoletin, psoralen, bergapten, xanthotoxin, columbianetin acetate, IMPERATORIN (cas 148-83-4), osthole and isoIMPERATORIN (cas 148-83-4) in rat plasma by LC–MS/MS for pharmacokinetic studies following oral administration of Radix Angelicae Pubescentis extract09/30/2019
- Activating the pregnane X receptor by IMPERATORIN (cas 148-83-4) attenuates dextran sulphate sodium‐induced colitis in mice09/28/2019