1.Identification

1.1 GHS Product identifier

1.2 Other means of identification

1.3 Recommended use of the chemical and restrictions on use

1.4 Supplier's details

1.5 Emergency phone number

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 4

Acute toxicity - Dermal, Category 4

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed H312 Harmful in contact with skin
Precautionary statement(s)
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection.
Response	P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P312 Call a POISON CENTER/doctor/…if you feel unwell. P321 Specific treatment (see ... on this label). P362+P364 Take off contaminated clothing and wash it before reuse.
Storage	none
Disposal	P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

In case of skin contact

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Rest. Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

Very toxic; the probable oral lethal dose in humans is between 50-500 mg/kg, or between 1 teaspoon and 1 ounce for a 70 kg (150 lb.) person. Dimethoate is a cholinesterase inhibitor, meaning it affects the central nervous system. Death is due to respiratory arrest arising from failure of respiratory center, paralysis of respiratory muscles, intense bronchoconstriction or all three. (EPA, 1998)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Antidote for acute dimethoate poisoning: 1. Adults: After cyanosis is overcome, use atropine sulfate, 2-4 mg iv. Repeat doses at 5- to 10-min intervals until signs of atropinization appear. Maintain for 24 hr or longer if necessary. 2. Children: Atropine sulfate in proportion to body weight: approx 0.05 mg/kg. 3. Support atropine treatment with 2-PAM (pralidoxime chloride) ... Adult dose: 1 g, slowly, intravenously; Infants: 0.25 g, slowly intravenously ... contraindicated are morphine, aminophylline, theophylline, phenothiazine tranquilizers, and barbiturates. /from table/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Dry chemicals, carbon dioxide for small fires. Water spray or foam for larger fires.

5.2 Specific hazards arising from the chemical

As with other organophosphorus pesticides, container may explode in heat of fire. The temperature of storage should not exceed 70-80F. Keep away from sources of heat, flames, or spark-generating equipment. Unstable in alkaline solution. Hydrolyzed by aqueous alkali. Stable in aqueous solutions. The compound is stable for 2 years under environmental conditions if stored in undamaged, original containers. (EPA, 1998)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Do NOT wash away into sewer. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Personal protection: chemical protection suit including self-contained breathing apparatus.

6.3 Methods and materials for containment and cleaning up

Use of granular, activated carbon in the adsorption of pesticides from wastewater is presented. Dimethoate was one of the compounds studied.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs. Keep in a well-ventilated room.The biological activity remains practically unvaried for 2 yr under environmental conditions, provided stored in unopened and undamaged original containers, in shaded, cool, well-aired places, inaccessible to animals & unauthorized persons. Recommended temp < 25°C/77 deg F. Crystals may form in formulations stored at < 32 deg F/0°C. Stable a minimum of 1 yr at < 25-30°C/77-86 deg F. Stack containers to permit air circulation at bottom & inside of piles. Do not contaminate food, feed products.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

The biological activity remains practically unvaried for 2 yr under environmental conditions, provided stored in unopened and undamaged original containers, in shaded, cool, well-aired places. ... Crystals may form in formulations stored at < 32 deg F/0°C. Stable a minimum of 1 yr at < 25-30°C/77-86 deg F.

10.3 Possibility of hazardous reactions

DIMETHOATE is incompatible with alkaline preparations. It is slightly corrosive to iron. It is incompatible with sulfur based formulations. . Organophosphates are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Dimethoate may decompose violently at temperatures >60°C due to catalytic effects. However, it is not considered to be an explosive.

10.6 Hazardous decomposition products

When heated to decomposition it emits very toxic fumes of /nitrogen, phosphorous, and sulfur oxides/.

11.Toxicological information

Acute toxicity

• Oral: LD50 Rat female oral 240-336 mg/kg technical material /From table/
• Inhalation: LC50 Rat inhalation >1.553 mg/L/4 hr /formulated as EC 400 g/L//
• Dermal: LD50 Rat percutaneous > 800 mg/kg

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

Cancer Classification: Group C Possible Human Carcinogen

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

• Toxicity to fish: LC50 Lepomis macrochirus (Bluegill, weight 0.3 g) 6.0 mg/L/96 hr; temp 24°C. Static bioassay without aeration, pH 7.2-7.5, water hardness 40-50 mg/L as calcium carbonate and alkalinity of 30-35 mg/L. /Technical, 97.4%
• Toxicity to daphnia and other aquatic invertebrates: LC50 Daphnia magna (Water flea) 2.50 mg/L/48 hr /from table; Conditions of bioassay not specified
• Toxicity to algae: no data available
• Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: The concn of dimethoate left (initial concn 10 ppb) after various times in raw water from Little Miami river at pH 7.3-8.0 was 10 ppb after 1 hr, 10 ppb after 1 wk, 8.5 ppb after 2 wks, 7.5 ppb after 4wks, and 5.0 ppb after 8 wks(1). Biodegradation may play a minor role in the disappearance of dimethoate in the river water; no experiments were conducted with sterilized river water(1). Half-lives of 171, 173 and 219 days were given for river water, filtered river water and sea water, respectively at 6°C, and 43, 29 and 36 days at 22°C(2). Percent degradation in chehalis clay loam soil in 2 wk, non-sterile, 77%, autoclaved, 18%, irradiated, 20%(3). Half-lives in soil in June-July averaged 11 days, and less than 2% of applied dimethoate residue detected after 10 months(3). Dimethoate half-lives in soil from Zhejiang Province, China were given as 5.1 and 7.1 days in 1989 and 1990, respectively(4). Dimethoate was given a half-life of 7 days(5-7) and 11 days(8) in an unspecified field soil sample. In laboratory experiments at 20-30°C half-lives for degradation were 28.9 and 36.7 days(3). However, dimethoate degraded faster when incubated for 30 days in samples of autoclaved sand, sandy clay loam, loam, and clay soils than in similarly treated nonsterile soils(9). Biodegradation appears to depend on the soil type and the microorganisms present in the soil(9). A half-life of 122 days has been observed in soil(10) which also suggests that biodegradation of dimethoate can be slow. In moist soils, dimethoate is readily oxidized to dimethoxon(11), but the role of microbial degradation on the removal of dimethoate from the environment is uncertain(12). Recovery of dimethoate incubated with enrichment cultures using raw sewage: 0 days, 54 ppm; 0.5 days, 54 ppm; 1 day, 52.5 ppm; 6 days, 22.4 ppm; 9 days, 13.5 ppm; 12 days, not detected(13). Using an initial concn of 100 mg/L dimethoate, 0-17 %Theoretical BOD was observed after a 4 week period in a biodegradation screening test using 30 mg/L sludge(14). Dimethoate has been reported to have an aerobic half-life of 2.2 days(15).

12.3 Bioaccumulative potential

After a 6 week period in a flow through system at 25°C, BCF ranges of 1.1-2.4 and 2.7-6 were determined in carp (Cyprinus carpio) using initial concns of 1 and 0.1 mg/L dimethoate, respectively(1). According to a classification scheme(3), these BCFs suggest the potential for bioconcentration in aquatic organisms is low(SRC). Bioconcentration of dimethoate in Mytillus galloprovincialis after 92 hours exposure at concentrations of 3.2, 5.6, 10, 32 and 56 ug/L was 1.0, 1.1, 1.4, 2.0 and 3.1 ug/g, respectively(3). Bioconcentration of dimethoate in Venus gallina after 92 hours exposure at concentrations of 5.6, 10 and 32 ug/L was 2.2, 2.3 and 3.1 ug/g, respectively(3).

12.4 Mobility in soil

The Koc values for dimethoate were measured to be 18 and 36 in a clay loam soil and clay soil, respectively(1). In other studies, the Koc was measured to be 5.2(2), 50(3) and 17(4) in unspecified soils. The Pesticide Properties Database lists the experimental Koc value for dimethoate as 20(5). According to a suggested classification scheme(6), these Koc values suggest that dimethoate will have very high mobility in soil. Average dimethoate losses due to leaching of various soil columns with the equivalent of 2.5 cm of rain ranged from 39.6% (clay) to 78.6% (sand)(7). In four soils containing less than 1% organic content, the soil TLC Rf values ranged from 0.89 to 0.97(8). The soil TLC Rf values in two other soils (0.35-1.05% OC) was 0.40-0.50 and was not affected by pH or salt concentration changes(9). Of 7 values sited in literature the mean Kd is 0.45(10). Kds were given for soil A (2.4 % clay, 0.8% silt, 96.4% sand, 2.1% organic material, pH 5.3) and soil B (13.4 % clay, 10.8% silt, 75% sand, 1.5% organic material, pH 6.4) as 0.08 and 0.05, respectively(11).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

14.2 UN Proper Shipping Name

14.3 Transport hazard class(es)

14.4 Packing group, if applicable

14.5 Environmental hazards

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

16.Other information

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.