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(+)-Pilocarpine hydrochloride

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Name

(+)-Pilocarpine hydrochloride

EINECS 200-212-5
CAS No. 54-71-7 Density 1.22 g/cm3
Solubility 100 mg/mL in water Melting Point 199-204 °C
Formula C11H16N2O2.HCl Boiling Point 431.8 °C at 760 mmHg
Molecular Weight 244.75 Flash Point 215 °C
Transport Information UN 1544 6.1/PG 3 Appearance white crystalline solid
Safety 25-45 Risk Codes 26/28
Molecular Structure Molecular Structure of 54-71-7 ((+)-Pilocarpine hydrochloride) Hazard Symbols VeryT+
Synonyms

2(3H)-Furanone,3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, monohydrochloride,(3S,4R)- (9CI);2(3H)-Furanone,3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, monohydrochloride,(3S-cis)-;Pilocarpine, monohydrochloride (8CI);(+)-Pilocarpine hydrochloride;Adsorbocarpine;Almocarpine;Isopto Carpine;NSC 5746;Pilocar;Pilocar SMP;Pilocarpal;Pilocarpine chloride;Pilocarpine hydrochloride;Pilocarpinemuriate;Pilocarpinium chloride;Pilocel;Pilovisc;Salagen;Sanpilo;Vistacarpin N;

 

(+)-Pilocarpine hydrochloride Chemical Properties

The Molecular formula of  PILOCARPINE MONOHYDROCHLORIDE(54-71-7):C11H17ClN2O2
The Molecular Weight of  PILOCARPINE MONOHYDROCHLORIDE(54-71-7):244.72 
The Molecular Structure of  PILOCARPINE MONOHYDROCHLORIDE(54-71-7) is:
Melting point:202-205 °C(lit.) 
Boiling point:431.8 °C at 760 mmHg
Flash point:215 °C    
Solubility in water:100 mg/mL
Sensitive:Hygroscopic
Merck:14,7424
Enthalpy of Vaporization:68.75 kJ/mol  
Vapour Pressure:1.16E-07 mmHg at 25°
Appearance:crystalline Solid  
IUPAC Name:(3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one hydrochloride
Synonyms:ALMOCARPINE HYDROCHLORIDE;3-ETHYL-4-[(1-METHYL-5-IMIDAZOLYL)METHYL]TETRAHYDROFURAN-2-ONE HYDROCHLORIDE;(3S,4R)-4,5-DIHYDRO-3-ETHYL-4-(1-METHYL-1H-IMIDAZOL-5-YLMETHYL)-2(3H)-FURANONE HYDROCHLORIDE;(3S-CIS)-3-ETHYLDIHYDRO-4-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2(3H)-FURANONE HYDROCHLORIDE;PILOCARPINE HCL;(+)-PILOCARPINE HYDROCHLORIDE;PILOCARPINE HYDROCHLORIDE;(3s-cis)-ochlorid

(+)-Pilocarpine hydrochloride Uses

Antiglaucoma agent; miotic; sialogogue.

(+)-Pilocarpine hydrochloride Toxicity Data With Reference

1.   

ocu-man TDLo:200 µg/kg/7H-I:CVS

   AIMDAP    Archives of Internal Medicine. 147 (1987),586.
2.   

orl-mus LD50:200 mg/kg

   NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),646.
3.   

ipr-mus LD50:155 mg/kg

   ATXKA8    Archiv fuer Toxikologie. 29 (1972),39.
4.   

ivn-pgn LDLo:353 mg/kg

   HBAMAK    “Abdernalden’s Handbuch der Biologischen Arbeitsmethoden.“ 4 (1935),1289.

(+)-Pilocarpine hydrochloride Consensus Reports

Reported in EPA TSCA Inventory.

(+)-Pilocarpine hydrochloride Safety Profile

Poison by ingestion, intraperitoneal, and intravenous routes. Experimental teratogenic and reproductive effects. Human systemic effects: cardiac changes. When heated to decomposition it emits very toxic fumes of HCl and NOx. See also PILOCARPINE
Hazard Codes:T+
T+ :Very Toxic
Risk Statements
R26/28:Very Toxic by inhalation and if swallowed .
Safety Statements
S25:Avoid contact with eyes .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
RIDADR:UN 1544 6.1/PG 3
WGK Germany:3
RTECS:TK1450000
F:3-8-10
F3:Hygroscopic.
F8:Photosensitive.
F10:Keep under argon.
HazardClass:6.1
PackingGroup:III


 

(+)-Pilocarpine hydrochloride Specification

Chemical Stability: Stable. 
Incompatibilities with Other Materials Strong oxidizing agents. 
Conditions to Avoid: Incompatible materials, light, exposure to moist air or water, heat
Hazardous Decomposition Products Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide, oxides of chlorine. 
Hazardous Polymerization Will not occur.  
   

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