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Name |
(R)-(+)-3-(N-Methylamino)-1-(2-thienyl)-1-propanol |
EINECS | 171.26 |
CAS No. | 116539-57-2 | Density | 1.128 |
PSA | 60.50000 | LogP | 1.78190 |
Solubility | N/A | Melting Point |
N/A |
Formula | C8H13NOS | Boiling Point | 294.3±35.0 °C(Predicted) |
Molecular Weight | 171.263 | Flash Point | N/A |
Transport Information | N/A | Appearance | N/A |
Safety | Risk Codes | N/A | |
Molecular Structure | Hazard Symbols | N/A | |
Synonyms |
(R)-(+)-3-(N-METHYLAMINO)-1-(2-THIENYL)-1-PROPANOL;(1R)-3-(Methylamino)-1-(2-thienyl)-1-propanol;(R)-3-Methylamino-1-(2-thienyl)-1-propanol;N-Methyl[(R)-3-hydroxy-3-(2-thienyl)propyl]amine;(R)-3-(Methylamino)-1-(thiophen-2-yl)propan-1-ol |
Article Data | 18 |
(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
Conditions | Yield |
---|---|
With hydrogen; potassium carbonate; [Rh{(RC,SP)-duanphos}(norbornadiene)]SbF6 In methanol at 20℃; under 7500.6 Torr; for 12h; | 93% |
(R)-(3-hydroxy-3-thiophen-2-yl-propyl)carbamic acid ethyl ester
(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran for 1.5h; Heating; | 88% |
With lithium aluminium tetrahydride In tetrahydrofuran for 14h; Reflux; | 87% |
With lithium aluminium tetrahydride In tetrahydrofuran for 2h; Heating; |
A
(S)-3-methylamino-1-(2-thienyl)-1-propanol
B
(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride Product distribution / selectivity; | A 74% B n/a |
With hydrogen; sodium methylate; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (S)-(-)-(6,6’-dimethoxybiphenyl-2,2’-diyl)bis(diphenylphosphine) In methanol at 30 - 50℃; under 22502.3 Torr; for 24h; Product distribution / selectivity; | A 12.7 - 20.4 %Chromat. B n/a |
With hydrogen; sodium methylate; ethyl acetoacetate; [(12aS)-6,7-dihudrodibenzo[e,g][1,4]dioxocin-1,12-diyl]bis[diphenylphosphine]; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate In methanol at 50℃; under 22502.3 Torr; for 24h; Product distribution / selectivity; | A 6.2 %Chromat. B n/a |
With hydrogen; [(12aS)-6,7-dihudrodibenzo[e,g][1,4]dioxocin-1,12-diyl]bis[diphenylphosphine]; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2 In methanol at 50℃; under 22502.3 Torr; for 24h; Product distribution / selectivity; | A 11.6 %Chromat. B n/a |
With hydrogen; [(12aS)-6,7-dihudrodibenzo[e,g][1,4]dioxocin-1,12-diyl]bis[diphenylphosphine]; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate In methanol at 50℃; under 22502.3 Torr; for 24h; Product distribution / selectivity; | A 4 %Chromat. B n/a |
(R)-3-chloro-1-thiophenyl-2-yl-propan-1-ol
methylamine
(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
Conditions | Yield |
---|---|
In ethanol at 90℃; Sealed tube; | 62% |
In ethanol; water at 130℃; for 1h; Sealed tube; | 55% |
In ethanol at 90℃; Sealed tube; | 41% |
In ethanol at 90℃; Sealed tube; | 41% |
(1S,2R)-1-amino-2-indanol
A
(S)-3-methylamino-1-(2-thienyl)-1-propanol
B
(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
Conditions | Yield |
---|---|
With sodium hydroxide; (p-cymene)-ruthenium(II) chloride dimer In isopropyl alcohol at 20 - 85℃; for 5h; | A 39% B n/a |
3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
A
(S)-3-methylamino-1-(2-thienyl)-1-propanol
B
(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
Conditions | Yield |
---|---|
With (S)-Mandelic acid In water at 29 - 50℃; | A 27% B n/a |
With diethylamine In ethanol; n-heptane Resolution of racemate; |
(2R,6R)-2-[(S)-1-triisopropylsilyloxyethyl]-3-methyl-6-(thiophen-2-yl)-1,3-oxazinane
(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
Conditions | Yield |
---|---|
With hydrogenchloride In tetrahydrofuran; water at 20℃; for 4h; |
(2R,6R)-2-[(S)-1-triisopropylsilyloxyethyl]-6-(thiophen-2-yl)-[1,3]oxazinan-4-one
(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: LiHMDS / tetrahydrofuran / 0 - 20 °C 2: Ph2SiH2 / RhH(CO)(PPh3)3 / tetrahydrofuran / 15 h / 20 °C 3: HCl / H2O; tetrahydrofuran / 4 h / 20 °C View Scheme |
(2R,6R)-N-methyl-2-[(S)-1-triisopropylsilyloxyethyl]-6-(thiophen-2-yl)-[1,3]oxazinan-4-one
(R)-3-(methylamino)-1-(thiophen-2-yl)propan-1-ol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Ph2SiH2 / RhH(CO)(PPh3)3 / tetrahydrofuran / 15 h / 20 °C 2: HCl / H2O; tetrahydrofuran / 4 h / 20 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 54 percent / BF3*Et2O / CH2Cl2 / -78 - 20 °C 2: aluminum amalgam / propan-2-ol 3: LiHMDS / tetrahydrofuran / 0 - 20 °C 4: Ph2SiH2 / RhH(CO)(PPh3)3 / tetrahydrofuran / 15 h / 20 °C 5: HCl / H2O; tetrahydrofuran / 4 h / 20 °C View Scheme |