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(R)-1-Boc-3-aminopiperidine
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Name

(R)-1-Boc-3-aminopiperidine

 EINECS 628-472-9
CAS No. 188111-79-7 Density 1.041g/cm3
PSA 55.56000 LogP 1.98280
Solubility Immiscible with water. Melting Point N/A
Formula C10H20N2O2 Boiling Point 277.3 °C at 760 mmHg
Molecular Weight 200.281 Flash Point 121.5 °C
Transport Information UN 2735 Appearance N/A
Safety 26 Risk Codes 22-36/37/38
Molecular Structure Molecular Structure of 188111-79-7 ((R)-1-Boc-3-Aminopiperidine) Hazard Symbols HarmfulXn
Synonyms

(R)-1-BOC-3-Aminopiperidine;(R)-3-Amino-1-N-BOC-piperidine;(R)-1-Boc-3-aminopiperidine;(R)-(-)-3-Amino-1-Boc-piperidine;tert-butyl (3R)3-aminopiperidine-1-carboxylate;(R)-3-aminopiperidine-1-carboxylic acid tert-butyl ester;(R)-(-)-1-Boc-3-aminopiperidine;(R)-tert-Butyl 3-aminopiperidine-1-carboxylate;(R)-tert-butyl 3-aminopiperidine-1-carboxylate;

Article Data 5

(R)-1-Boc-3-aminopiperidine Synthetic route

320580-76-5

tert-butyl (3R)-3-{[(benzyloxy)carbonyl]amino}piperidine-1-carboxylate

188111-79-7

tert-butyl (3R)3-aminopiperidine-1-carboxylate

Conditions
ConditionsYield
Pd-C In methanol99%

C10H18N2O2

188111-79-7

tert-butyl (3R)3-aminopiperidine-1-carboxylate

Conditions
ConditionsYield
With bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; C13H18FeP2; hydrogen; sodium hydride In dichloromethane Large scale;95.2%
915226-43-6

(R)-tert-butyl 3-carbamoylpiperidine-1-carboxylate

188111-79-7

tert-butyl (3R)3-aminopiperidine-1-carboxylate

Conditions
ConditionsYield
With sodium hypochlorite; sodium hydroxide In water at 15 - 25℃; for 16h;80%
98977-36-7

3-oxo-piperidine-1-carboxylic acid tert-butyl ester

188111-79-7

tert-butyl (3R)3-aminopiperidine-1-carboxylate

Conditions
ConditionsYield
With pyridoxal 5'-phosphate; immobilized Codex® amine ω-transaminase; isopropylamine In dimethyl sulfoxide at 50℃; pH=7.5; Temperature; Enzymatic reaction; enantioselective reaction;70%
Multi-step reaction with 2 steps
1: ammonium acetate / ethanol / 7 h / Reflux; Large scale
2: bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; sodium hydride; C13H18FeP2; hydrogen / dichloromethane / Large scale
View Scheme
188111-79-7

tert-butyl (3R)3-aminopiperidine-1-carboxylate

77628-51-4

6-methylimidazo<2,1-b>thiazole-5-carboxylic acid

1030389-10-6

(R)-3-[(6-methyl-imidazo[2,1-b]thiazole-5-carbonyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 20h;100%
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 20h;100%
188111-79-7

tert-butyl (3R)3-aminopiperidine-1-carboxylate

313339-92-3

3,5-dichloro-pyrazine-2-carbonitrile

1207852-79-6

tert-butyl (3R)-3-[(6-chloro-5-cyanopyrazin-2-yl)amino]piperidine-1-carboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 1h;100%
With N-ethyl-N,N-diisopropylamine In butan-1-ol at 20 - 50℃;60%
188111-79-7

tert-butyl (3R)3-aminopiperidine-1-carboxylate

1313279-53-6

3-(4-chloro-5-nitropyrimidin-2-yl)-6-fluoroimidazo[1,2-a]pyridine

1313279-69-4

(R)-tert-butyl 3-(2-(6-fluoroimidazo[1,2-a]pyridin-3-yl)-5-nitropyrimidin-4-ylamino)piperidine-1-carboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃;100%
188111-79-7

tert-butyl (3R)3-aminopiperidine-1-carboxylate

1943-83-5

2-chloroethyl isothiocyanate

tert-butyl (3R)-3-{[(2-chloroethyl)carbamoyl]amino}piperidine-1-carboxylate

Conditions
ConditionsYield
With triethylamine In dichloromethane for 4.41667h;100%
With triethylamine In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran at 20℃; for 4h;81.5%
188111-79-7

tert-butyl (3R)3-aminopiperidine-1-carboxylate

100-09-4

4-methoxybenzoic acid

(R)-tert-butyl 3-(4-methoxybenzamido)piperidine-1-carboxylate

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In 1,4-dioxane; N,N-dimethyl-formamide at 20℃; for 3h;100%
188111-79-7

tert-butyl (3R)3-aminopiperidine-1-carboxylate

3-(4,6-dichloro-5-fluoropyrimidin-2-yl)pyrazolo[1,5-a]pyridine

tert-butyl (3R)-3-[(6-chloro-5-fluoro-2-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-4-yl)amino]piperidine-1-carboxylate

Conditions
ConditionsYield
With triethylamine In ethanol at 80℃; for 48h;100%
With triethylamine In ethanol at 80℃; for 48h;100%

(R)-1-Boc-3-aminopiperidine Specification

The (R)-1-Boc-3-aminopiperidine, with the CAS registry number 188111-79-7, is also known as (R)-3-Amino-1-N-Boc-piperidine. It belongs to the product categories of Aminoacid; Pharmacetical; Piperidine; Piperidine Series; Piperidines; Chiral Chemicals. This chemical's molecular formula is C10H20N2O2 and molecular weight is 200.278. Its IUPAC name is called tert-butyl (3R)-3-aminopiperidine-1-carboxylate.

Physical properties of (R)-1-Boc-3-aminopiperidine: (1)ACD/LogP: 0.71; (2)ACD/LogD (pH 5.5): -2.35; (3)ACD/LogD (pH 7.4): -1.53; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 4; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 3; (11)Index of Refraction: 1.483; (12)Molar Refractivity: 54.99 cm3; (13)Molar Volume: 192.2 cm3; (14)Surface Tension: 37.8 dyne/cm; (15)Density: 1.041 g/cm3; (16)Flash Point: 121.5 °C; (17)Enthalpy of Vaporization: 51.59 kJ/mol; (18)Boiling Point: 277.3 °C at 760 mmHg; (19)Vapour Pressure: 0.00456 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
This chemical may cause damage to health. It is harmful if swallowed. In addition, it is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CC(C)(C)OC(=O)N1CCCC(C1)N
(2)Isomeric SMILES: CC(C)(C)OC(=O)N1CCC[C@H](C1)N
(3)InChI: InChI=1S/C10H20N2O2/c1-10(2,3)14-9(13)12-6-4-5-8(11)7-12/h8H,4-7,11H2,1-3H3/t8-/m1/s1
(4)InChIKey: AKQXKEBCONUWCL-MRVPVSSYSA-N

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