- (S)-(+)-1-(1-Naphthyl)ethyl isocyanate
- (S)-(+)-1-(2-Chlorophenyl)-1,2-ethanediol
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- (S)-(+)-1,1'-Bi-2-naphthyl ditosylate
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- (S)-(+)-1,2,3,4-Tetrahydro-1-naphthol
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Cas Database |
| Name |
(S)-(+)-1,2-Propanediol |
EINECS | N/A |
| CAS No. | 4254-15-3 | Density | 1.036 g/cm3 |
| PSA | 40.46000 | LogP | -0.64050 |
| Solubility | soluble in water | Melting Point |
-59 °C |
| Formula | C3H8O2 | Boiling Point | 184.8 °C at 760 mmHg |
| Molecular Weight | 76.0953 | Flash Point | 107.2 °C |
| Transport Information | N/A | Appearance | Colorless to light yellow liquid |
| Safety | 24/25-36/37/39-26 | Risk Codes | 36/37/38-22 |
| Molecular Structure |
|
Hazard Symbols |
 Xn
|
| Synonyms |
1,2-Propanediol,(S)-(+)- (8CI);(+)-(S)-1,2-Propanediol;(+)-1,2-Propanediol;(S)-(+)-Propane-1,2-diol;(S)-(+)-Propylene glycol;(S)-1,2-Propanediol;(S)-2-Hydroxy-1-propanol;(S)-2-Hydroxypropanol;(S)-Propylene glycol;1,2(S)-Propanediol;3-Deoxy-sn-glycerol;L-(+)-Propanediol;L-(+)-Propyleneglycol;L-1,2-Propanediol;d-Propylene glycol; |
Article Data | 116 |
(S)-(+)-1,2-Propanediol Synthetic route
| Conditions | Yield |
|---|---|
| With [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); hydrogen bromide; hydrogen; (S)-[(5,6),(5’,6’)-bis(ethylenedioxy)biphenyl-2,2’ diyl]bis(diphenylphosphine) In ethanol; water at 60℃; under 825.083 Torr; for 1h; pH=1.34; Catalytic behavior; Pressure; Temperature; pH-value; Reagent/catalyst; Autoclave; | 100% |
| With hydrogen; RuBr2[(S)-(C6H2OCH2CH2OP(C6H5)2)2] In methanol at 80℃; under 22501.8 Torr; for 40h; | 89% |
| With potassium hydroxide; ammonium formate; 2-hydroxyethanethiol In water for 216h; GDH, FDH, NAD, pH = 7.5 - 8.3; | 50% |
- 1067232-34-1
(4S,1'R,2'S)-N(3)-[1'-(m-chlorobenzoyl)-2'-hydroxy-propan-1'-yl]-4-phenyl-5,5-dimethyloxazolidin-2-one
A
- 4254-15-3
(S)-1,2-Propanediol
B
- 168297-84-5
(4S)-5,5-dimethyl-4-phenyl-1,3-oxazolidin-2-one
| Conditions | Yield |
|---|---|
| With sodium tetrahydroborate In methanol for 0.166667h; | A 37% B 99% |
| Conditions | Yield |
|---|---|
| With lithium aluminium tetrahydride In diethyl ether for 0.5h; Heating; | 97% |
| Stage #1: (S)-Ethyl lactate With lithium aluminium tetrahydride In diethyl ether at 0 - 20℃; for 4h; Stage #2: With water In tetrahydrofuran; diethyl ether at 0℃; | 86% |
| With lithium aluminium tetrahydride In diethyl ether | 80% |
- 13807-91-5, 89401-28-5, 103129-25-5, 85483-97-2
(2S)-1-(benzyloxy)propan-2-ol
- 4254-15-3
(S)-1,2-Propanediol
| Conditions | Yield |
|---|---|
| With hydrogen; palladium on activated charcoal In methanol for 30h; | 96% |
- 27871-49-4
(S)-Methyl lactate
- 4254-15-3
(S)-1,2-Propanediol
| Conditions | Yield |
|---|---|
| With lithium aluminium tetrahydride In diethyl ether at 0 - 20℃; for 2.25h; | 90% |
| With lithium aluminium tetrahydride In tetrahydrofuran at 25℃; for 1h; | |
| With hydrogen; Nishimura catalyst <(45.9% Rh/19.9% Pt) oxide> In methanol at 25℃; under 75007.5 Torr; | 77 % Spectr. |
- 85550-19-2
(S)-1-triphenylmethoxypropan-2-ol
- 4254-15-3
(S)-1,2-Propanediol
| Conditions | Yield |
|---|---|
| With silica gel supported sodium hydrogen sulfate In methanol; dichloromethane at 20℃; | 81% |
- 76946-21-9
(2S)-2-(tetrahydro-2H-pyran-2-yloxy)propan-1-ol
- 4254-15-3
(S)-1,2-Propanediol
| Conditions | Yield |
|---|---|
| With hydrogenchloride In methanol for 12h; | 80% |
| Conditions | Yield |
|---|---|
| With [RuH(CO)(BPy-tPNN*)]; hydrogen In tetrahydrofuran at 110℃; under 38002.6 Torr; for 12h; Inert atmosphere; | 73% |
| With hydrogen In methanol at 100℃; under 112511 Torr; for 15h; Autoclave; stereoselective reaction; | 80 %Chromat. |
- 1369852-90-3
(S)-1-(9H-fluoren-9-yloxy)propan-2-ol
- 4254-15-3
(S)-1,2-Propanediol
| Conditions | Yield |
|---|---|
| With palladium 10% on activated carbon; hydrogen In methanol | 73% |
- 41274-09-3
(R)-3-tosyloxy-1,2-propanediol
- 4254-15-3
(S)-1,2-Propanediol
| Conditions | Yield |
|---|---|
| With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 4h; | 72% |
(S)-(+)-1,2-Propanediol Chemical Properties
IUPAC Name:propane-1,2-diol
Molecular Formula:C3H8O2
Molecular Weight:76.094420 g/mol
Appearance:clear colorless liquid
Melting Point:-59 °C
Boiling Point:186-188 °C at 765 mm Hg(lit.)
Flash Point:225 °F
Solubility:water
alpha:16 °(c=neat)
density:1.036 g/mL at 20 °C(lit.)
refractive index:n20/D 1.432(lit.)
Sensitive:Hygroscopic
Merck:14,7855
BRN:1718871
Synonyms of S-1,2-Propanediol(4254-15-3):
(S)-(+)-Propane-1,2-diol;(S)-Propane-1,2-diol;L-(+)-PROPYLENE GLYCOL;(S)-(+)-PROPANEDIOL;(S)-(+)-PROPYLENE GLYCEROL;(S)-(+)-PROPYLENE GLYCOL;(S)-(+)-1,2-DIHYDROXYPROPANE;(S)-(+)-1,2-PROPANEDIOL;(S)-(+)-1,2-Propanediol
Categories of S-1,2-Propanediol(4254-15-3):
Chiral Compounds;Diols;chiral;Chiral Building Blocks;Simple Alcohols (Chiral);Synthetic Organic Chemistry;Chiral Compound
(S)-(+)-1,2-Propanediol Uses
(S)-(+)-1,2-Propanediol Safety Profile
Hazard Codes:Xn
Risk Statements:36/37/38-22
36/37/38:Irritating to eyes, respiratory system and skin
22:Harmful if swallowed
Safety Statements:24/25-36/37/39-26
24/25:Avoid contact with skin and eyes
36/37/39:Wear suitable protective clothing, gloves and eye/face protection
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
WGK Germany:1
(S)-(+)-1,2-Propanediol Specification
First Aid Measures of S-1,2-Propanediol(4254-15-3):
Eyes:Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:Get medical aid. Wash mouth out with water.
Inhalation:Remove from exposure and move to fresh air immediately.
Storage of S-1,2-Propanediol(4254-15-3):
Store in a cool, dry place. Store in a tightly closed container.
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