Basic Information | Post buying leads | Suppliers | Cas Database |
Name |
(S)-1-Boc-3-hydroxypiperidine |
EINECS | N/A |
CAS No. | 143900-44-1 | Density | 1.107 g/cm3 |
PSA | 49.77000 | LogP | 1.31610 |
Solubility | N/A | Melting Point |
34-40 °C |
Formula | C10H19NO3 | Boiling Point | 292.3 °C at 760 mmHg |
Molecular Weight | 201.266 | Flash Point | 130.6 °C |
Transport Information | N/A | Appearance | N/A |
Safety | 26-36/37/39 | Risk Codes | 36/37/38 |
Molecular Structure | Hazard Symbols | Xi | |
Synonyms |
1-Piperidinecarboxylicacid, 3-hydroxy-, 1,1-dimethylethyl ester, (S)-;(S)-3-Hydroxypiperidine-1-carboxylic acid tert-butyl ester;(S)-N-Boc-3-hydroxypiperidine;1,1-Dimethylethyl(3S)-3-hydroxy-1-piperidinecarboxylate;1-Boc-(3S)-3-hydroxypiperidine; |
Article Data | 26 |
(S)-3-hydroxypiperidine hydrochloride
di-tert-butyl dicarbonate
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
With dmap; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 66h; | 98% |
With sodium hydrogencarbonate In ethanol; water at 21 - 22℃; | 98.9% |
With triethylamine In methanol at 20℃; for 0.5h; |
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
With rac-octan-2-ol In aq. buffer at 35℃; for 12h; pH=8; Reagent/catalyst; pH-value; Temperature; Enzymatic reaction; enantioselective reaction; | 98.08% |
With D-glucose; NADP In aq. phosphate buffer; ethanol at 30℃; for 4h; pH=6; enantioselective reaction; | 96% |
With recombinant Rhodococcus erythropolis DSM 43297 ketoredutase; nicotinamide adenine dinucleotide In aq. phosphate buffer; isopropyl alcohol at 50℃; for 0.5h; pH=7.0; Enzymatic reaction; stereoselective reaction; | 95% |
di-tert-butyl dicarbonate
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
With sodium hydroxide In water at 20℃; for 3h; Time; Large scale; | 97% |
di-tert-butyl dicarbonate
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; for 48h; | 83% |
di-tert-butyl dicarbonate
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 10℃; | 73.95% |
di-tert-butyl dicarbonate
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In ethyl acetate | 65% |
vinyl n-butyrate
N-tert-butoxycarbonyl-3-piperidinol
A
tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate
B
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
With savinase enzyme; N-ethyl-N,N-diisopropylamine In toluene for 42h; Reagent/catalyst; Solvent; Resolution of racemate; Enzymatic reaction; | A n/a B n/a C 31.7% |
vinyl acetate
N-tert-butoxycarbonyl-3-piperidinol
A
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
With Lipase PS In pentane at 20℃; for 4h; | A n/a B 22% |
3-methoxymethoxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 98 percent / hydrogen / PtO2 / ethyl acetate / 1 h 2: HCl / methanol; H2O / 7 h / 20 °C 3: triethylamine / methanol / 0.5 h / 20 °C View Scheme |
tert-butyl (S)-3-(methoxymethoxy)piperidine-1-carboxylate
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: HCl / methanol; H2O / 7 h / 20 °C 2: triethylamine / methanol / 0.5 h / 20 °C View Scheme |