Basic Information | Post buying leads | Suppliers | Cas Database |
Name |
(Z)-Hymenialdisine |
EINECS | N/A |
CAS No. | 82005-12-7 | Density | 2.2 g/cm3 |
PSA | 112.37000 | LogP | 0.85980 |
Solubility | Soluble in DMSO. | Melting Point |
160-164oC |
Formula | C11H10BrN5O2 | Boiling Point | N/A |
Molecular Weight | 324.137 | Flash Point | N/A |
Transport Information | N/A | Appearance | Light Yellow Solid |
Safety | Risk Codes | N/A | |
Molecular Structure | Hazard Symbols | N/A | |
Synonyms |
Pyrrolo[2,3-c]azepin-8(1H)-one,4-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-2-bromo-4,5,6,7-tetrahydro-,(Z)-;Hymenialdesine;Hymenialdisine; |
Article Data | 5 |
The (Z)-Hymenialdisine, with the CAS registry number 82005-12-7, is also known as Pyrrolo(2,3-c)azepin-8(1H)-one,4-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-2-bromo-4,5,6,7-tetrahydro-, (4Z)-. It belongs to the product categories of Protein Kinase Inhibitors and Activators; Heterocycles; Tyrosine Kinase Inhibitors. This chemical's molecular formula is C11H10BrN5O2 and molecular weight is 324.13. What's more, it is light yellow solid and it should be kept in a cold and dry place.
Preparation of (Z)-Hymenialdisine: this chemical can be prepared by 4-(2-Amino-3H-imidazol-4-yl)-2,5-dibromo-6,7-dihydro-1H-pyrrolo[2,3-c]azepin-8-one. This reaction needs reagent AcOH at temperature of 120 °C. The reaction time is 48 hours. The yield is 65 %.
Uses of (Z)-Hymenialdisine: (1) it is used as a potent inhibitor of a variety of kinases including MEK-1, GSK-3, and CKI; (2) it also exhibits inhibition of the G2 cell cycle checkpoint at the micromolar concentrations; (3) it is used as a marine sponge alkaloid, a natural product.