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1-(2-Furoyl)piperazine
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Name

1-(2-Furoyl)piperazine

 EINECS 254-823-7
CAS No. 40172-95-0 Density 1.175 g/cm3
PSA 45.48000 LogP 0.59170
Solubility N/A Melting Point 67-70 °C(lit.)
Formula C9H12N2O2 Boiling Point 320.3 °C at 760 mmHg
Molecular Weight 180.206 Flash Point 147.5 °C
Transport Information N/A Appearance white to light yellow solid
Safety 26-36-24/25 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 40172-95-0 (1-(2-Furoyl)piperazine) Hazard Symbols IrritantXi
Synonyms

Piperazine,1-(2-furanylcarbonyl)- (9CI);(Furan-2-yl)(piperazin-1-yl)methanone;1-(2-Furanylcarbonyl)piperazine;1-(2-Furylcarbonyl)piperazine;1-(Furan-2-carbonyl)piperazine;4-(Furan-2-ylcarbonyl)piperazine;N-(2-Furancarbonyl)piperazine;N-(2-Furoyl)piperazine;N-(Furan-2-oyl)piperazine;Methanone,2-furanyl-1-piperazinyl-;

Article Data 30

1-(2-Furoyl)piperazine Synthetic route

110-85-0

piperazine

88-14-2

2-furanoic acid

40172-95-0

N-(furan-2-carbonyl)piperazine

Conditions
ConditionsYield
With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In dichloromethane at 20℃; for 0.166667h;92%
Stage #1: 2-furanoic acid With N-Bromosuccinimide; triphenylphosphine In dichloromethane at 0 - 5℃; for 0.25h;
Stage #2: piperazine With pyridine In dichloromethane at 20℃; for 0.583333h;		86%
110-85-0

piperazine

614-99-3

Ethyl 2-furoate

A

31350-27-3

N,N'-bis(furan-2-carbonyl)piperazine

B

40172-95-0

N-(furan-2-carbonyl)piperazine

Conditions
ConditionsYield
at 110℃; for 3h;A 6%
B 89%
110-85-0

piperazine

88-14-2

2-furanoic acid

A

31350-27-3

N,N'-bis(furan-2-carbonyl)piperazine

B

40172-95-0

N-(furan-2-carbonyl)piperazine

Conditions
ConditionsYield
With 1,1,1,3,3,3-hexamethyl-disilazane at 110℃; for 8h; Yields of byproduct given;A n/a
B 83%
110-85-0

piperazine

88-14-2

2-furanoic acid

999-97-3

1,1,1,3,3,3-hexamethyl-disilazane

40172-95-0

N-(furan-2-carbonyl)piperazine

Conditions
ConditionsYield
In dichloromethane83%
110-85-0

piperazine

611-13-2

2-furoic acid methyl ester

40172-95-0

N-(furan-2-carbonyl)piperazine

Conditions
ConditionsYield
64%
527-69-5

2-furancarbonyl chloride

57260-71-6

1-t-Butoxycarbonylpiperazine

40172-95-0

N-(furan-2-carbonyl)piperazine

Conditions
ConditionsYield
With hydrogenchloride; triethylamine 1.) THF, r.t., 2 h, 2.) THF, 20 deg C, 2 h; Yield given. Multistep reaction;
110-85-0

piperazine

527-69-5

2-furancarbonyl chloride

40172-95-0

N-(furan-2-carbonyl)piperazine

Conditions
ConditionsYield
With sodium hydroxide; hydrogen bromide; potassium carbonate 1.) aq. monoglyme, 3 h; Yield given. Multistep reaction;
527-69-5

2-furancarbonyl chloride

142-63-2

piperazine hexahydrate

40172-95-0

N-(furan-2-carbonyl)piperazine

Conditions
ConditionsYield
With sodium hydroxide In water108.2 g product (60%)
With sodium hydroxide In water108.2 g product (60%)
With sodium hydroxide In water108.2 g product (60%)
With sodium hydroxide In water108.2 g product (60%)
With sodium hydroxide108.2 g. product (60%)
110-85-0

piperazine

527-69-5

2-furancarbonyl chloride

1-cyano-4-(2-furoyl)piperazine

40172-95-0

N-(furan-2-carbonyl)piperazine

Conditions
ConditionsYield
With hydrogenchloride; sodium hydroxide In diethyl ether; ethanol; acetone

tert-butyl 4-(furan-2-carbonyl)piperazine-1-carboxylate

40172-95-0

N-(furan-2-carbonyl)piperazine

Conditions
ConditionsYield
Acidic conditions;
With hydrogenchloride; water In dichloromethane at 20℃;
With hydrogenchloride In methanol; diethyl ether

1-(2-Furoyl)piperazine Chemical Properties

IUPAC Name: Furan-2-yl(piperazin-1-yl)methanone 
Synonyms: (Furan-2-yl)(piperazin-1-yl)methanone ; Piperazine,1-(2-furanylcarbonyl)- (9CI) ; 1-(2-Furanoyl)piperazine ; 1-(2-Furanylcarbonyl)piperazine ; 1-(Furan-2-carbonyl)piperazine ; 4-(Furan-2-ylcarbonyl)piperazine ; N-(2-Furoyl)piperazine
EINECS: 254-823-7
Molecular Weight: 180.20378 [g/mol]
Molecular Formula: C9H12N2O2
XLogP3-AA: 0.1
H-Bond Donor: 1
H-Bond Acceptor: 3
Melting Point: 67-70 °C(lit.)
Index of Refraction: 1.529
Molar Refractivity: 47.3 cm3
Molar Volume: 153.3 cm3
Surface Tension: 41.5 dyne/cm
Density: 1.175 g/cm3
Flash Point: 147.5 °C
Enthalpy of Vaporization: 56.19 kJ/mol
Boiling Point: 320.3 °C at 760 mmHg
Vapour Pressure: 0.000321 mmHg at 25 °C 
Sensitive: Hygroscopic
Appearance: white to light yellow solid
Product Categories: Piperidines, Piperidones, Piperazines; BUILDING BLOCKS; API intermediates
Following is the molecular structure of 1-(2-Furoyl)piperazine (CAS NO.40172-95-0) is:

1-(2-Furoyl)piperazine Safety Profile

Hazard Codes: IrritantXi
Risk Statements:
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing. 
S24/25:Avoid contact with skin and eyes.
WGK Germany: 3
F: 10-34
Hazard Note: Irritant
HazardClass: IRRITANT

1-(2-Furoyl)piperazine Specification

 1-(2-Furoyl)piperazine (CAS NO.40172-95-0) is a white to light yellow solid.
First Aid Measures about it:
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin: Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion: Get medical aid. Wash mouth out with water.
Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. 
Handling and Storage about it:
Handling: Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Storage: Store in a cool, dry place. Keep container closed when not in use.

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