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Cas Database

Name	1-(2-Furoyl)piperazine	EINECS	254-823-7
CAS No.	40172-95-0	Density	1.175 g/cm³
PSA	45.48000	LogP	0.59170
Solubility	N/A	Melting Point	67-70 °C(lit.)
Formula	C₉H₁₂N₂O₂	Boiling Point	320.3 °C at 760 mmHg
Molecular Weight	180.206	Flash Point	147.5 °C
Transport Information	N/A	Appearance	white to light yellow solid
Safety	26-36-24/25	Risk Codes	36/37/38
Molecular Structure		Hazard Symbols	Xi
Synonyms	Piperazine,1-(2-furanylcarbonyl)- (9CI);(Furan-2-yl)(piperazin-1-yl)methanone;1-(2-Furanylcarbonyl)piperazine;1-(2-Furylcarbonyl)piperazine;1-(Furan-2-carbonyl)piperazine;4-(Furan-2-ylcarbonyl)piperazine;N-(2-Furancarbonyl)piperazine;N-(2-Furoyl)piperazine;N-(Furan-2-oyl)piperazine;Methanone,2-furanyl-1-piperazinyl-;	Article Data	30

1-(2-Furoyl)piperazine Synthetic route

: 110-85-0
piperazine

: 88-14-2
2-furanoic acid

: 40172-95-0
N-(furan-2-carbonyl)piperazine

Conditions

Conditions	Yield
With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In dichloromethane at 20℃; for 0.166667h;	92%
Stage #1: 2-furanoic acid With N-Bromosuccinimide; triphenylphosphine In dichloromethane at 0 - 5℃; for 0.25h; Stage #2: piperazine With pyridine In dichloromethane at 20℃; for 0.583333h;	86%

: 110-85-0
piperazine

: 614-99-3
Ethyl 2-furoate

A: 31350-27-3
N,N'-bis(furan-2-carbonyl)piperazine

B: 40172-95-0
N-(furan-2-carbonyl)piperazine

Conditions

Conditions	Yield
at 110℃; for 3h;	A 6% B 89%

: 110-85-0
piperazine

: 88-14-2
2-furanoic acid

A: 31350-27-3
N,N'-bis(furan-2-carbonyl)piperazine

B: 40172-95-0
N-(furan-2-carbonyl)piperazine

Conditions

Conditions	Yield
With 1,1,1,3,3,3-hexamethyl-disilazane at 110℃; for 8h; Yields of byproduct given;	A n/a B 83%

: 110-85-0
piperazine

: 88-14-2
2-furanoic acid

: 999-97-3
1,1,1,3,3,3-hexamethyl-disilazane

: 40172-95-0
N-(furan-2-carbonyl)piperazine

Conditions

Conditions	Yield
In dichloromethane	83%

: 110-85-0
piperazine

: 611-13-2
2-furoic acid methyl ester

: 40172-95-0
N-(furan-2-carbonyl)piperazine

Conditions

Conditions	Yield
	64%

: 527-69-5
2-furancarbonyl chloride

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 40172-95-0
N-(furan-2-carbonyl)piperazine

Conditions

Conditions	Yield
With hydrogenchloride; triethylamine 1.) THF, r.t., 2 h, 2.) THF, 20 deg C, 2 h; Yield given. Multistep reaction;

: 110-85-0
piperazine

: 527-69-5
2-furancarbonyl chloride

: 40172-95-0
N-(furan-2-carbonyl)piperazine

Conditions

Conditions	Yield
With sodium hydroxide; hydrogen bromide; potassium carbonate 1.) aq. monoglyme, 3 h; Yield given. Multistep reaction;

: 527-69-5
2-furancarbonyl chloride

: 142-63-2
piperazine hexahydrate

: 40172-95-0
N-(furan-2-carbonyl)piperazine

Conditions

Conditions	Yield
With sodium hydroxide In water	108.2 g product (60%)
With sodium hydroxide In water	108.2 g product (60%)
With sodium hydroxide In water	108.2 g product (60%)
With sodium hydroxide In water	108.2 g product (60%)
With sodium hydroxide	108.2 g. product (60%)

: 110-85-0
piperazine

: 527-69-5
2-furancarbonyl chloride

: 1-cyano-4-(2-furoyl)piperazine

: 40172-95-0
N-(furan-2-carbonyl)piperazine

Conditions

Conditions	Yield
With hydrogenchloride; sodium hydroxide In diethyl ether; ethanol; acetone

: tert-butyl 4-(furan-2-carbonyl)piperazine-1-carboxylate

: 40172-95-0
N-(furan-2-carbonyl)piperazine

Conditions

Conditions	Yield
Acidic conditions;
With hydrogenchloride; water In dichloromethane at 20℃;
With hydrogenchloride In methanol; diethyl ether

1-(2-Furoyl)piperazine Chemical Properties

IUPAC Name: Furan-2-yl(piperazin-1-yl)methanone
Synonyms: (Furan-2-yl)(piperazin-1-yl)methanone ; Piperazine,1-(2-furanylcarbonyl)- (9CI) ; 1-(2-Furanoyl)piperazine ; 1-(2-Furanylcarbonyl)piperazine ; 1-(Furan-2-carbonyl)piperazine ; 4-(Furan-2-ylcarbonyl)piperazine ; N-(2-Furoyl)piperazine
EINECS: 254-823-7
Molecular Weight: 180.20378 [g/mol]
Molecular Formula: C₉H₁₂N₂O₂
XLogP3-AA: 0.1
H-Bond Donor: 1
H-Bond Acceptor: 3
Melting Point: 67-70 °C(lit.)
Index of Refraction: 1.529
Molar Refractivity: 47.3 cm³
Molar Volume: 153.3 cm³
Surface Tension: 41.5 dyne/cm
Density: 1.175 g/cm³
Flash Point: 147.5 °C
Enthalpy of Vaporization: 56.19 kJ/mol
Boiling Point: 320.3 °C at 760 mmHg
Vapour Pressure: 0.000321 mmHg at 25 °C
Sensitive: Hygroscopic
Appearance: white to light yellow solid
Product Categories: Piperidines, Piperidones, Piperazines; BUILDING BLOCKS; API intermediates
Following is the molecular structure of 1-(2-Furoyl)piperazine (CAS NO.40172-95-0) is:

1-(2-Furoyl)piperazine Safety Profile

Hazard Codes: Irritant Xi
Risk Statements:
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S24/25:Avoid contact with skin and eyes.
WGK Germany: 3
F: 10-34
Hazard Note: Irritant
HazardClass: IRRITANT

1-(2-Furoyl)piperazine Specification

1-(2-Furoyl)piperazine (CAS NO.40172-95-0) is a white to light yellow solid.
First Aid Measures about it:
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin: Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion: Get medical aid. Wash mouth out with water.
Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Handling and Storage about it:
Handling: Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Storage: Store in a cool, dry place. Keep container closed when not in use.

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