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1,1,3,3-Tetramethoxypropane

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Name

1,1,3,3-Tetramethoxypropane

EINECS 203-037-2
CAS No. 102-52-3 Density 0.964 g/cm3
PSA 36.92000 LogP 0.61430
Solubility Immiscible with water Melting Point N/A
Formula C7H16O4 Boiling Point 183 °C at 760 mmHg
Molecular Weight 164.202 Flash Point 54.4 °C
Transport Information UN 1993 3/PG 3 Appearance clear colourless to yellow-brown liquid
Safety 16-26-36/37/39 Risk Codes 10-36/37/38
Molecular Structure Molecular Structure of 102-52-3 (1,1,3,3-Tetramethoxypropane) Hazard Symbols FlammableF
Synonyms

Malonaldehyde,bis(dimethyl acetal) (6CI,7CI,8CI);AI3-28938;Malonaldehyde tetramethyl acetal;NSC 27794;Tetramethoxypropane;Propane, 1,1,3,3-tetramethoxy-;

Article Data 23

1,1,3,3-Tetramethoxypropane Synthetic route

107-25-5

methoxyethene

149-73-5

trimethyl orthoformate

A

102-52-3

malonaldehydebis(dimethylacetal)

B

55546-58-2

1,1,3,5,5-pentamethoxy-pentane

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In dichloromethane at -78℃; for 6h;A 65%
B 8%
67-56-1

methanol

1165952-92-0

cyclohexa-1,4-diene

A

7424-91-1

methyl 3,3-dimethoxypropionate

B

102-52-3

malonaldehydebis(dimethylacetal)

C

108-59-8

malonic acid dimethyl ester

Conditions
ConditionsYield
With hydrogenchloride; ozone -40 deg C, then ca. 30 min reflux; Yields of byproduct given;A 60%
B n/a
C n/a
With hydrogenchloride; ozone at -40℃; -40 deg C, then ca. 30 min reflux; Yield given;A 60%
B n/a
C n/a
With hydrogenchloride; ozone at -40℃; Product distribution;A 60%
B n/a
C n/a
108-05-4

vinyl acetate

149-73-5

trimethyl orthoformate

102-52-3

malonaldehydebis(dimethylacetal)

Conditions
ConditionsYield
With iron(III) chloride; sodium hydrogencarbonate 1) 2 h, reflux; 2) 20 deg C, 2 h;36%
With iron(III) chloride at 60℃;
67-56-1

methanol

98561-07-0

1,1,3-trimethoxy-3-acethoxypropane

102-52-3

malonaldehydebis(dimethylacetal)

Conditions
ConditionsYield
With boron fluoride ether
107-25-5

methoxyethene

109-63-7

trifluoroborane diethyl ether

149-73-5

trimethyl orthoformate

A

123-59-1

1-ethoxy-1,3,3-trimethoxypropane

B

102-52-3

malonaldehydebis(dimethylacetal)

107-25-5

methoxyethene

149-73-5

trimethyl orthoformate

102-52-3

malonaldehydebis(dimethylacetal)

Conditions
ConditionsYield
With boron fluoride ether
at 84℃; under 37.5038 Torr; for 1h; Reactivity; Gas phase;
With boron trifluoride diethyl etherate Reactivity; Gas phase;
With boron fluoride ether
67-56-1

methanol

624-67-9

Propargylic aldehyde

102-52-3

malonaldehydebis(dimethylacetal)

Conditions
ConditionsYield
(i) N-methylpiperidine, (ii) HCl; Multistep reaction;
67-56-1

methanol

2862-47-7

3-phenoxy-propenal

102-52-3

malonaldehydebis(dimethylacetal)

67-56-1

methanol

19060-10-7

3,3-dimethoxypropanal

102-52-3

malonaldehydebis(dimethylacetal)

Conditions
ConditionsYield
With hydrogenchloride
67-56-1

methanol

123331-77-1

(Z)-1,1,6,6-Tetramethoxy-3-hexen

A

7424-91-1

methyl 3,3-dimethoxypropionate

B

102-52-3

malonaldehydebis(dimethylacetal)

Conditions
ConditionsYield
With hydrogenchloride; ozone 1.) -40 deg C, 2.) reflux, 1 h; Yield given. Multistep reaction;
With hydrogenchloride; reflux; ozone

1,1,3,3-Tetramethoxypropane Chemical Properties

IUPAC Name: 1,1,3,3-Tetramethoxypropane
Synonyms of 1,1,3,3-Tetramethoxypropane (CAS NO.203-037-2): Malonaldehyde bis(dimethyl acetal) ; Malonaldehyde tetramethyl acetal ; Tetramethoxypropane ; Malonaldehyde, bis(dimethyl acetal) (8CI) ; Propane, 1,1,3,3-tetramethoxy-
CAS NO: 203-037-2
Molecular Formula: C7H16O4
Molecular Weight: 164.20
Molecular Structure:
EINECS: 203-037-2
H bond acceptors: 4
H bond donors: 0
Freely Rotating Bonds: 6
Polar Surface Area: 36.92 Å2
Index of Refraction: 1.401
Molar Refractivity: 41.37 cm3
Molar Volume: 170.2 cm3
Surface Tension: 25.8 dyne/cm
Density: 0.964 g/cm3
Flash Point: 54.4 °C
Enthalpy of Vaporization: 40.21 kJ/mol
Boiling Point: 183 °C at 760 mmHg
Vapour Pressure: 1.08 mmHg at 25°C
Water solubility: Immiscible
Sensitive: Moisture Sensitive
Appearance: 1,1,3,3-Tetramethoxypropane (CAS NO.203-037-2) is clear colourless to yellow-brown liquid.
SMILES: O(C)C(OC)CC(OC)OC
InChI: InChI=1/C7H16O4/c1-8-6(9-2)5-7(10-3)11-4/h6-7H,5H2,1-4H3
InChIKey: XHTYQFMRBQUCPX-UHFFFAOYAP
Std. InChI: InChI=1S/C7H16O4/c1-8-6(9-2)5-7(10-3)11-4/h6-7H,5H2,1-4H3
Std. InChIKey: XHTYQFMRBQUCPX-UHFFFAOYSA-N

1,1,3,3-Tetramethoxypropane Safety Profile

Safety Information of 1,1,3,3-Tetramethoxypropane (CAS NO.203-037-2) :
Hazard Codes: FlammableF
Risk Statements: 10-36/37/38
R10: Flammable. 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 16-26-36/37/39
S16:Keep away from sources of ignition. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: UN 1993 3/PG 3
WGK Germany: 1
F: 21
Hazard Note: Irritant
HazardClass: 3
PackingGroup: III
HS Code: 29110000
 

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