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1,2:5,6-Bis-O-(1-methylethylidene)-D-mannitol

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Name

1,2:5,6-Bis-O-(1-methylethylidene)-D-mannitol

EINECS 216-954-8
CAS No. 1707-77-3 Density 1.175 g/cm3
PSA 77.38000 LogP 0.01120
Solubility N/A Melting Point 120-122 °C(lit.)
Formula C12H22O6 Boiling Point 382 °C at 760 mmHg
Molecular Weight 262.303 Flash Point 184.8 °C
Transport Information N/A Appearance odorless White crystalline.
Safety 22-24/25-36/37-26 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 1707-77-3 (1,2:5,6-Bis-O-(1-methylethylidene)-D-mannitol) Hazard Symbols IrritantXi
Synonyms

Mannitol,1,2:5,6-di-O-isopropylidene-, D- (8CI);1,2:5,6-Di-O-isopropylidene-D-mannitol;1,2:5,6-Diisopropylidene-D-mannitol;D-(+)-1,2:5,6-Di-O-isopropylidenemannitol;D-Mannitol 1,2:5,6-bis-acetonide;

Article Data 96

1,2:5,6-Bis-O-(1-methylethylidene)-D-mannitol Specification

The CAS registry number of D-Mannitol,1,2:5,6-bis-O-(1-methylethylidene)- is 1707-77-3. The IUPAC name is (1S,2S)-1,2-bis[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]ethane-1,2-diol. In addition, the molecular formula is C12H22O6 and the molecular weight is 262.30. What's more, it belongs to the classes of Biochemistry; Dioxanes & Dioxolanes; Dioxolanes; O-Substituted Sugars; Sugar Alcohols; Sugars; Carbohydrates. And should be stored in a cool and dry place.

Physical properties of D-Mannitol,1,2:5,6-bis-O-(1-methylethylidene)-: (1)ACD/LogP: 0.61; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.61; (4)ACD/LogD (pH 7.4): 0.61; (5)ACD/BCF (pH 5.5): 1.71; (6)ACD/BCF (pH 7.4): 1.71; (7)ACD/KOC (pH 5.5): 51.12; (8)ACD/KOC (pH 7.4): 51.12; (9)#H bond acceptors: 6; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 5; (12)Polar Surface Area: 55.38 Å2; (13)Index of Refraction: 1.476; (14)Molar Refractivity: 62.95 cm3; (15)Molar Volume: 223.1 cm3; (16)Polarizability: 24.95×10-24cm3; (17)Surface Tension: 37.3 dyne/cm; (18)Density: 1.175 g/cm3; (19)Flash Point: 184.8 °C; (20)Enthalpy of Vaporization: 72.91 kJ/mol; (21)Boiling Point: 382 °C at 760 mmHg; (22)Vapour Pressure: 2.08E-07 mmHg at 25°C.

Preparation of D-Mannitol,1,2:5,6-bis-O-(1-methylethylidene)-: it can be prepared by D-mannitol and 2-methoxy-propene. This reaction will need reagents desiccant and p-TsOH, and solvent dimethylformamide. The reaction time is 2 hours at reaction temperature of 0 °C. The yield is about 83%.

D-Mannitol,1,2:5,6-bis-O-(1-methylethylidene)- can be prepared by D-mannitol and 2-methoxy-propene

Uses of D-Mannitol,1,2:5,6-bis-O-(1-methylethylidene)-: it can react with acetic acid anhydride to get O3,O4-diacetyl-O1,O2;O5,O6-diisopropylidene-D-mannitol. This reaction will need solvent pyridine. The reaction time is 8 hours with ambient temperature. The yield is about 92%.

D-Mannitol,1,2:5,6-bis-O-(1-methylethylidene)- can react with acetic acid anhydride to get O3,O4-diacetyl-O1,O2;O5,O6-diisopropylidene-D-mannitol

When you are using this chemical, please be cautious about it as the following:
It irritates to eyes, respiratory system and skin. During using it, wear suitable protective clothing and gloves and avoid contact with skin and eyes. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. In addition, you should not breathe dust.

You can still convert the following datas into molecular structure:
(1)SMILES: OC(C1OC(OC1)(C)C)C(O)C2OC(OC2)(C)C
(2)InChI: InChI=1/C12H22O6/c1-11(2)15-5-7(17-11)9(13)10(14)8-6-16-12(3,4)18-8/h7-10,13-14H,5-6H2,1-4H3
(3)InChIKey: ODYBCPSCYHAGHA-UHFFFAOYAI

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