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1,2-Dimethylbenzene

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Name

1,2-Dimethylbenzene

EINECS 202-422-2
CAS No. 95-47-6 Density 0.87 g/cm3
PSA 0.00000 LogP 2.30340
Solubility miscible with ethanol, ether, acetone and benzene, insoluble in water Melting Point -26--23 °C
Formula C8H10 Boiling Point 145.949 °C at 760 mmHg
Molecular Weight 106.16 Flash Point 28.882 °C
Transport Information UN 1307 3/PG 3 Appearance colourless liquid
Safety 25-45-36/37-16-7 Risk Codes 10-20/21-38-39/23/24/25-23/24/25-11
Molecular Structure Molecular Structure of 95-47-6 (1,2-Dimethylbenzene) Hazard Symbols HarmfulXn,ToxicT,FlammableF
Synonyms

o-Xylene;o-Xylene(8CI);1,2-Xylene;2-Methyltoluene;3,4-Dimethylbenzene;NSC 60920;Orthoxylene;o-Dimethylbenzene;o-Methyltoluene;o-Xylol;ortho-Xylene;

 

1,2-Dimethylbenzene Synthetic route

methyl(o-tolyl)(1,2-bis(diphenylphosphino)benzene)palladium*(tetrahydrofuran)

13991-08-7

1,2-Bis(diphenylphosphino)benzene

A

85318-49-6

bis(1,2-bis(diphenylphosphino)benzene)palladium

B

95-47-6

o-xylene

Conditions
ConditionsYield
In benzene-d6 under N2; in NMR tube; react. of Pd complex and ligand (excess) in benzene-d6 at 40 for 2 h or at 90°C for < 10 min; monitored by (1)H NMR spectra;A n/a
B 99%
89-95-2

2-methyl-benzyl alcohol

95-47-6

o-xylene

Conditions
ConditionsYield
With palladium dichloride In methanol at 40℃; for 18h; Inert atmosphere; Green chemistry; chemoselective reaction;99%
With 2,4,6-trimethyl-pyridine; 4,4'-dimethoxyphenyl disulfide; iridium(lll) bis[2-(2,4-difluorophenyl)-5-methylpyridine-N,C20]-4,40-di-tert-butyl-2,20-bipyridine hexafluorophosphate; triphenylphosphine In toluene for 24h; Irradiation;66 %Chromat.
552-45-4

1-chloromethyl-2-methylbenzene

95-47-6

o-xylene

Conditions
ConditionsYield
With palladium dichloride In methanol at 40℃; for 1h; Green chemistry; chemoselective reaction;99%
2808-75-5, 58396-30-8

2-methyl-1-methylenecyclohexane

95-47-6

o-xylene

Conditions
ConditionsYield
With n-butyllithium; potassium 2-methylbutan-2-olate Mechanism; 1) r.t., 16 h, 2) reflux, 6 h; further reagent: D2O;97%
5973-71-7

3,4-dimethylbenzaldehyde

A

95-47-6

o-xylene

B

95-63-6

1,2,4-Trimethylbenzene

Conditions
ConditionsYield
With palladium/alumina; hydrogen In hexane at 325℃; Flow reactor; Green chemistry;A 96.2%
B 3.8%
With hydrogen In hexane at 325℃; Flow reactor; Green chemistry;A 15.9%
B 84.2%
55262-10-7

1,2-dimethyl-2,5-cyclohexadiene-1-carboxylic acid

95-47-6

o-xylene

Conditions
ConditionsYield
With chlorosulfonic acid In dichloromethane at 0℃; for 0.166667h;95%
529-19-1

2-Methylbenzonitrile

95-47-6

o-xylene

Conditions
ConditionsYield
With hydrogen; aluminum oxide; nickel at 150℃; under 760 Torr; various Nitriles;92%
With nickel-copper at 240℃; Hydrogenation;
615-60-1

4-chloro-1,2-dimethylbenzene

608-23-1

3-chloro-o-xylene

95-47-6

o-xylene

Conditions
ConditionsYield
With hydrogen; 5%-palladium/activated carbon at 290 - 320℃; for 1h;90%
201230-82-2

carbon monoxide

612-14-6

phthalyl alcohol

A

4385-35-7

isochroman-3-one

B

95-47-6

o-xylene

C

644-36-0

o-methylphenylacetic acid

Conditions
ConditionsYield
With hydrogen iodide; tetrakis(triphenylphosphine) palladium(0) In acetone at 90℃; under 68400 Torr; for 42h; Carbonylation; reduction;A 88%
B n/a
C 9%
With hydrogen iodide; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane at 120℃; under 68400 Torr; for 42h; Carbonylation; reduction;A 13%
B n/a
C 52%
7397-06-0

4-t-butyl-o-xylene

A

766-39-2

2,3-Dimethylmaleic anhydride

B

32703-79-0

4-tert-butylphthalic anhydride

C

74186-27-9

6-(tert-butyl)isobenzofuran-1(3H)-one

D

95-47-6

o-xylene

E

4-tert-butyl-phthalaldehyde

Conditions
ConditionsYield
With oxygen; phosphorus; titanium; oxides of V; aluminium at 345℃; for 0.000119444h; Product distribution; oth. temperature, oth. time, gas phase;A 3%
B 83%
C 1.8%
D n/a
E n/a
18022-66-7

3,4-dimethylcyclohex-3-ene-1-carboxaldehyde

A

95-47-6

o-xylene

B

95-63-6

1,2,4-Trimethylbenzene

Conditions
ConditionsYield
With hydrogen In hexane at 325℃; Flow reactor; Green chemistry;A 17.5%
B 80.9%
With palladium/alumina; hydrogen In hexane at 325℃; Flow reactor; Green chemistry;A 73%
B 27%
583-55-1

1-Bromo-2-iodobenzene

[3-(dimethylamino)propyl]dimethyl aluminium(III)

A

95-47-6

o-xylene

B

95-46-5

2-methylphenyl bromide

Conditions
ConditionsYield
With tetrakis(triphenylphosphine)palladium dichloride In benzene at 80℃;A 80%
B 13%
104-87-0

4-methyl-benzaldehyde

552-45-4

1-chloromethyl-2-methylbenzene

A

95-47-6

o-xylene

B

589-18-4

4-Methylbenzyl alcohol

C

952-80-7

1,2-bis(2-methylphenyl)ethane

D

113312-69-9

1-(4-methylphenyl)-2-(2-methylphenyl)ethanol

Conditions
ConditionsYield
With lithium In diethyl ether at 0℃; for 0.75h; Further byproducts given. Yields of byproduct given;A n/a
B n/a
C n/a
D 75%
612-12-4

o-Xylylene dichloride

A

95-47-6

o-xylene

B

694-87-1

benzocyclobutene

Conditions
ConditionsYield
With magnesium at 600℃;A 15%
B 73%
529-20-4

2-methylphenyl aldehyde

95-47-6

o-xylene

Conditions
ConditionsYield
With polymethylhydrosiloxane; iron(III) chloride hexahydrate In 1,2-dichloro-ethane at 120℃; for 1h; Microwave irradiation;73%
110-54-3

hexane

A

95-47-6

o-xylene

B

106-42-3

para-xylene

C

100-41-4

ethylbenzene

D

108-38-3

m-xylene

E

108-88-3

toluene

F

71-43-2

benzene

Conditions
ConditionsYield
540 degC; treated 16 h; U type zeolite at 450℃; Product distribution;A n/a
B n/a
C n/a
D n/a
E 10.8%
F 72.2%
540 degC; treated 16 h; UHS type zeolite at 450℃; Product distribution;A n/a
B n/a
C n/a
D n/a
E 33.3%
F 50%
89-92-9

2-methylbenzyl bromide

A

95-47-6

o-xylene

B

952-80-7

1,2-bis(2-methylphenyl)ethane

Conditions
ConditionsYield
With magnesium at 600℃;A 20%
B 70%
89-92-9

2-methylbenzyl bromide

A

95-47-6

o-xylene

B

694-87-1

benzocyclobutene

C

952-80-7

1,2-bis(2-methylphenyl)ethane

D

36888-18-3

(E)-2,2'-dimethylstilbene

Conditions
ConditionsYield
With magnesium at 600℃; under 0.15 Torr;A n/a
B n/a
C 70%
D n/a
201230-82-2

carbon monoxide

89-92-9

2-methylbenzyl bromide

A

95-47-6

o-xylene

B

644-36-0

o-methylphenylacetic acid

C

952-80-7

1,2-bis(2-methylphenyl)ethane

D

1,3-bis(3,4-methylphenyl)acetone

Conditions
ConditionsYield
With sodium hydroxide; cobalt tricarbonyl nitrosyl; trimethyldodecylammonium chloride In benzene under 760 Torr; Ambient temperature;A 4%
B 68%
C 12%
D 10%
89-92-9

2-methylbenzyl bromide

A

95-47-6

o-xylene

B

644-36-0

o-methylphenylacetic acid

C

952-80-7

1,2-bis(2-methylphenyl)ethane

D

1,3-bis(3,4-methylphenyl)acetone

Conditions
ConditionsYield
With sodium hydroxide; cobalt tricarbonyl nitrosyl; carbon monoxide; trimethyldodecylammonium chloride In benzene under 760 Torr; Ambient temperature;A 4%
B 68%
C 12%
D 10%
55262-10-7

1,2-dimethyl-2,5-cyclohexadiene-1-carboxylic acid

A

95-47-6

o-xylene

(1S,5R)-5-Hydroperoxy-1-methyl-6-methylene-cyclohex-2-enecarboxylic acid

(1S,5S)-5-Hydroperoxy-1-methyl-6-methylene-cyclohex-2-enecarboxylic acid

Conditions
ConditionsYield
With oxygen; 5,15,10,20-tetraphenylporphyrin In chloroform at -30℃; for 24h; Irradiation;A 19%
B 10%
C 68%
108-93-0

cyclohexanol

A

95-47-6

o-xylene

B

96-37-7

methyl-cyclopentane

C

110-82-7

cyclohexane

D

71-43-2

benzene

Conditions
ConditionsYield
With hydrogen; nickel(II) oxide; aluminum oxide; molybdenum(VI) oxide at 450℃; under 21001.7 Torr; for 0.75h; Further byproducts given;A n/a
B 20%
C 65%
D n/a
137092-35-4

Bis(dithiopivalinsaeure)-1,2-xylylenester

A

95-47-6

o-xylene

B

40920-16-9

methyl dithiopivalate

Conditions
ConditionsYield
In methanol cathodic reduction, Pt cathode;A 61%
B 50%
91-13-4

α,α'-dibromo-o-xylene

A

95-47-6

o-xylene

B

952-80-7

1,2-bis(2-methylphenyl)ethane

C

113245-36-6

α,α'-diethoxy-o-xylene

D

1,2-bis(o-ethoxymethylphenyl)ethane

Conditions
ConditionsYield
With sodium In toluene for 24h; Heating;A 60%
B n/a
C n/a
D n/a
1632-16-2

2-ethyl-1-hexene

A

95-47-6

o-xylene

B

106-42-3

para-xylene

C

100-41-4

ethylbenzene

Conditions
ConditionsYield
With tert-butylethylene; (iPr4PCOP)IrHCl; sodium t-butanolate at 200℃; for 120h; Concentration; Reagent/catalyst; Temperature;A 11%
B 60%
C 7%
142-82-5

n-heptane

A

95-47-6

o-xylene

B

106-42-3

para-xylene

C

100-41-4

ethylbenzene

D

108-38-3

m-xylene

E

108-88-3

toluene

F

71-43-2

benzene

Conditions
ConditionsYield
540 degC; treated 16 h; U type zeolite at 450℃; Product distribution;A n/a
B n/a
C n/a
D n/a
E 58.5%
F 6%
540 degC; treated 16 h; UHS type zeolite at 450℃; Product distribution;A n/a
B n/a
C n/a
D n/a
E 42.8%
F 8.8%
95-65-8

3,4-Dimethylphenol

95-47-6

o-xylene

Conditions
ConditionsYield
Stage #1: 3,4-Dimethylphenol With fluorosulfonyl fluoride; triethylamine In dimethyl sulfoxide at 20℃; for 3h;
Stage #2: With formic acid; 1,3-bis-(diphenylphosphino)propane; palladium diacetate In dimethyl sulfoxide at 20℃; for 2h;
58%
1933-71-7

2-methylsulfonyloxymethylbenzyl methanesulfonate

95-47-6

o-xylene

Conditions
ConditionsYield
With lithium; nickel dichloride In tetrahydrofuran at 20℃; Reduction;57%
3227-91-6

<4>Radialene

A

292638-84-7

styrene

B

95-47-6

o-xylene

C

536-74-3

phenylacetylene

D

108-88-3

toluene

E

71-43-2

benzene

Conditions
ConditionsYield
at 880℃; under 0.001 Torr;A 55%
B 6%
C n/a
D n/a
E n/a
95-47-6

o-xylene

85-44-9

phthalic anhydride

Conditions
ConditionsYield
With oxygen at 340 - 360℃;100%
With oxygen100%
With oxygen100%
95-47-6

o-xylene

583-57-3

1,2-Dimethyl-cyclohexane

Conditions
ConditionsYield
With hydrogen; [(norbornadiene)rhodium(I)chloride]2; phosphinated polydiacetylene In n-heptane at 30℃; under 60800 Torr; for 1.8h;100%
With Ti8O8(14+)*6C8H4O4(2-)*4O(2-)*3.3Li(1+)*0.7Co(2+)*0.7C4H8O*0.7H(1-); hydrogen In neat (no solvent) at 120℃; under 37503.8 Torr; for 18h;100%
With hydrogen In water at 100℃; under 15001.5 Torr; for 5h;99%
95-47-6

o-xylene

A

87-41-2

2-benzofuran-1(3H)-one

B

85-44-9

phthalic anhydride

Conditions
ConditionsYield
With oxygen at 340 - 360℃; Product distribution / selectivity;A 0.01%
B 100%
With oxygen at 340 - 360℃;A 0.1%
B 100%
With oxygen at 340 - 360℃;A 0.03%
B 100%
95-47-6

o-xylene

ortho-xylene chlorinated products; mixture of

ortho-xylene chlorinated products; mixture of

Conditions
ConditionsYield
With chlorine; manganese trisacetylacetonate; 10H-phenothiazine-10-carbonyl chloride at 10℃; under 760.051 Torr; for 0.833333h; Product distribution / selectivity;100%
95-47-6

o-xylene

ortho-xylene chlorinated products; mixture of

ortho-xylene chlorinated products; mixture of

Conditions
ConditionsYield
With chlorine; manganese trisacetylacetonate; 10H-phenothiazine-10-carbonyl chloride at 10℃; under 760.051 Torr; for 0.666667h; Product distribution / selectivity;100%
95-47-6

o-xylene

93-96-9

bis(1-phenylethyl)ether

6196-95-8

1,2-dimethyl-4-(1-phenylethyl)benzene

Conditions
ConditionsYield
With iron(III) chloride; chloro-trimethyl-silane In 1,2-dichloro-ethane at 20℃; for 0.166667h; Friedel-Crafts Alkylation; Inert atmosphere;100%
95-47-6

o-xylene

13540-56-2

4-benzyl-1,2-dimethylbenzene

Conditions
ConditionsYield
With phosphotungstic acid at 120℃; for 3h; Reagent/catalyst; Friedel-Crafts Alkylation;100%
95-47-6

o-xylene

2-chloro-5-(2-(3,4-dimethoxyphenyl)-1,1,1-trifluoropropan-2-yl)thiophene

2-(2-(3,4-dimethoxyphenyl)-1,1,1-trifluoropropan-2-yl)-4-(3,4-dimethylphenyl)thiophene

Conditions
ConditionsYield
With trifluorormethanesulfonic acid In dichloromethane at -40℃; for 6h;100%
95-47-6

o-xylene

6196-95-8

1,2-dimethyl-4-(1-phenylethyl)benzene

Conditions
ConditionsYield
With cross-linked poly acidic ionic liquids In N,N-dimethyl-formamide at 120℃; for 3h; Solvent; Temperature; High pressure;99.67%
With phosphotungstic acid at 120℃; for 3h; Reagent/catalyst;98.3%
With 12-tungstophosphoric acid supported 30percent triethylammonium acetate, P123 in micro/mesoporous silica at 119.84℃; for 3h; Catalytic behavior; Reagent/catalyst; Temperature; Friedel-Crafts Alkylation;93.8%
507-20-0

tertiary butyl chloride

95-47-6

o-xylene

7397-06-0

4-t-butyl-o-xylene

Conditions
ConditionsYield
With iodine at 50℃; Temperature;99.3%
With iron(III) chloride at 0 - 20℃;85%
With aluminium trichloride69%
85-44-9

phthalic anhydride

95-47-6

o-xylene

2159-42-4

2-(3,4-dimethylbenzoyl)benzoic acid

Conditions
ConditionsYield
With aluminum (III) chloride In neat (no solvent) for 1h; Friedel-Crafts Acylation; Milling;99%
With [bmim]Cl*AlCl3 at 30℃; for 3h; Friedel-Crafts reaction;95%
With aluminium trichloride for 0.166667h; Heating;37%
95-47-6

o-xylene

625-36-5

2-chloropropionyl chloride

22422-23-7

3-chloro-1-(3,4-dimethyl-phenyl)-propan-1-one

Conditions
ConditionsYield
With aluminum (III) chloride; nitromethane at 19 - 22℃; under 760.051 Torr; Friedel Crafts acylation; Inert atmosphere;99%
With aluminum (III) chloride In dichloromethane at 0 - 20℃; Friedel-Crafts acylation; Inert atmosphere;98%
With aluminum (III) chloride In dichloromethane at 25℃; for 3h;96%
95-47-6

o-xylene

135584-30-4

1-(3,4-dimethylphenyl)-2-phenyl-1-propanone

Conditions
ConditionsYield
With aluminium trichloride In carbon disulfide for 14h; Ambient temperature;99%
95-47-6

o-xylene

ortho-xylene chlorinated products; mixture of

ortho-xylene chlorinated products; mixture of

Conditions
ConditionsYield
With chlorine; manganese trisacetylacetonate; 10H-phenothiazine-10-carbonyl chloride at 10℃; under 760.051 Torr; for 0.583333h; Product distribution / selectivity;99%
95-47-6

o-xylene

199620-14-9, 13007-92-6

chromium(0) hexacarbonyl

12129-29-2

(η6-o-xylene)tricarbonylchromium(0)

Conditions
ConditionsYield
In tetrahydrofuran; dibutyl ether refluxing for 1 wk; evapn. of solvents under vac., removing unreacted (Cr(CO)6) by sublimation, recrystn. from CH2Cl2 under N2;99%
With catalyst: CH3COOC4H9 In decalin byproducts: CO; (Ar); refluxed for 3 h; cooled to 20°C; filtered through Kieselguhr; catalyst evapd.; chromy.; evapd.; crystd. from benzene/pertoleum ether at -18°C;98%
With catalyst: butyl acetate In decalin byproducts: CO; refluxing for 2.5 h (catalyst: butyl acetate); freezing out at -18°C or quick chromy. of the decaline soln. on a SiO2 column;98%

Reed’s acid

95-47-6

o-xylene

[H(m-xylene)][CB11H6Br6]*(o-xylene)

Conditions
ConditionsYield
In o-xylene Schlenkware or glovebox; o-xylene was added to solid carborane acid; mixt. was stirred for few min; solvent removed (vac.); elem. anal.;99%
95-47-6

o-xylene

18734-63-9

perfluoro-o-phenylenemercury trimer

649559-06-8

perfluoro-ortho-phenylene mercury trimer - ortho-xylene (1:1)

Conditions
ConditionsYield
In further solvent(s) Hg-compound was dissolved by boiling in o-xylene, cooled; slow evapd. in a well-aerated fume hood; elem. anal.;99%
95-47-6

o-xylene

65-85-0

benzoic acid

38418-11-0

2-methylbenzyl benzoate

Conditions
ConditionsYield
With tetra-(n-butyl)ammonium iodide In water at 80℃; for 3h;99%
With di-tert-butyl peroxide; C11H23N2(1+)*Br4Fe(1-) at 110℃; for 24h;99%
With tert.-butylhydroperoxide; choline chloride; tetra-(n-butyl)ammonium iodide; urea In water at 80℃; for 12h; Green chemistry;90%
95-47-6

o-xylene

3972-65-4

1-bromo-4-tert-butylbenzene

70663-11-5

1-(4-(tert-butyl) benzyl)-2-methylbenzene

Conditions
ConditionsYield
With Xantphos-Pd-G3; potassium hexamethylsilazane at 110℃; for 12h; Inert atmosphere; Sealed tube;99%
677-71-4

hexafluoroacetone hydrate

95-47-6

o-xylene

65294-20-4

4,4'-(hexafluoroisopropylidene)-bis-(o-xylene)

Conditions
ConditionsYield
With hydrogen fluoride at 100℃; under 7980.54 Torr; for 13h; Concentration; Temperature; Autoclave;98.7%
108-30-5

succinic acid anhydride

95-47-6

o-xylene

51036-98-7

3-(3,4-dimethylbenzoyl)propionic acid

Conditions
ConditionsYield
With aluminum (III) chloride In dichloromethane at 20℃; for 2h; Friedel-Crafts Acylation;98%
With [bmim]Cl*AlCl3 at 30℃; for 3h; Friedel-Crafts reaction;95%
With aluminium trichloride In dichloromethane86%
91-01-0

1,1-Diphenylmethanol

95-47-6

o-xylene

500362-29-8

((3,4-dimethylphenyl)methylene)dibenzene

Conditions
ConditionsYield
With H5CoW12O40 supported on rice husk ash extracted nano silica at 60℃; for 0.5h; Reagent/catalyst; Green chemistry;98%
With boron trifluoride diethyl etherate; water at 80℃; for 2h; regioselective reaction;93%
With (diethylamino)difluorosulfonium tetrafluoroborate In dichloromethane at 20℃; for 48h; Inert atmosphere;89%
With phosphorus pentoxide
With 1-butyl-3-methylimidazolium tetrachloridoferrate(III) at 80℃; for 12h; Friedel-Crafts type benzylation; regioselective reaction;56 %Chromat.
95-47-6

o-xylene

89-92-9

2-methylbenzyl bromide

Conditions
ConditionsYield
With bromine In tetrachloromethane Solvent;98%
With bromine In tetrachloromethane for 1.5h; Ambient temperature;97%
With 2,4,4,6-Tetrabromo-2,5-cyclohexadien-1-one; silica gel for 4.5h; UV-irradiation;82%
768-90-1

1-Adamantyl bromide

95-47-6

o-xylene

62133-11-3

1-(1-adamantyl)-3,4-dimethylbenzene

Conditions
ConditionsYield
With potassium carbonate; palladium on activated charcoal at 120℃; for 12h;98%
With zinc(II) chloride Substitution; Heating;92%
With zinc(II) chloride for 10h; Heating;90%
With molybdenum hexacarbonyl at 120℃; for 2h; Sealed tube; regioselective reaction;72%
507-19-7

t-butyl bromide

95-47-6

o-xylene

7397-06-0

4-t-butyl-o-xylene

Conditions
ConditionsYield
With pyrographite for 24h; Heating;98%
95-47-6

o-xylene

558-17-8

tert-Butyl iodide

7397-06-0

4-t-butyl-o-xylene

Conditions
ConditionsYield
pyrographite for 24h; Heating;98%
95-47-6

o-xylene

trifluoroethyl (phenyl)diazoacetate

2,2,2-trifluoroethyl 2-(3,4-dimethylphenyl)-2-phenylacetate

Conditions
ConditionsYield
With C42H63O3P*Au(1+)*C7H5N*F6Sb(1-) at 20℃; for 0.05h; Schlenk technique;98%

1,2-Dimethylbenzene Consensus Reports

Community Right-To-Know List. Reported in EPA TSCA Inventory.

1,2-Dimethylbenzene Standards and Recommendations

OSHA PEL: TWA 100 ppm; STEL 150 ppm
ACGIH TLV: TWA 100 ppm; STEL 150 ppm; BEI: methyl hippuric acids in urine at end of shift 1.5 g/g creatinine; Not Classifiable as a Human Carcinogen
NIOSH REL: (Xylene) TWA 100 ppm; CL 200 ppm/10M
DOT Classification:  3; Label: Flammable Liquid

1,2-Dimethylbenzene Specification

1,2-Dimethylbenzene, also known o-Xylene, is colourless, flammable liquid with aromatic smell. It is an aromatic hydrocarbon, based on benzene with two methyl substituents bonded to adjacent carbon atoms in the aromatic ring (the ortho configuration). What's more, 1,2-Dimethylbenzene is miscible with ethanol, ether, acetone and benzene, insoluble in water.

Preparation: 1,2-Dimethylbenzene was mainly obtained from coal tar originally, but now the majority of domestic and overseas extract this product from oil catalytic reforming and aromatics thermal cracking. As the structure of 1,2-Dimethylbenzene, p-xylene, m-xylene is very similar, their physical parameters vary little. In industry, the separation of 1,2-Dimethylbenzene uses superfractionation. The rectification requires about 150 tower plates and reflux ratio 5-8 and consumes more energy.

Use industrial 1,2-dimethylbenzene as raw material. First, use industrial concentrated sulfuric acid to wash to acid layer colorless. Then wash the mixture with 10% sodium hydroxide solution and water to be qualified. After the separation of water layer, dry with anhydrous calcium chloride. And then rectify until distillate clear. Finally, collecting the midbarrel, the product is pure.

Uses: 1,2-Dimethylbenzene is mainly used as chemical raw material and solvent. It can be used in the production of phthalic anhydride, phthalic nitrile, dimethyl phenol, dimethylaniline, dyes, pesticide, drug (such as vitamin) and so on. It is also used as aviation gasoline additive. In addition, 1,2-Dimethylbenzene is used in organic synthesis. For example: it can react with benzoyl chloride to get 3,4-dimethyl-benzophenone. This reaction which is a kind of Friedel-Crafts acylation needs reagent BiCl3 at temperature of 120 °C. The reaction time is 12 hours. The yield is 93%.

1,2-Dimethylbenzene can react with benzoyl chloride to get 3,4-dimethyl-benzophenone

Safty: 1,2-Dimethylbenzene is harmful by inhalation and in contact with skin. It is specially irritating to skin. And people also should avoid contact with eyes. If you want to contact this product, you must wear suitable protective clothing and gloves. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

Structure Descriptors:
1. Smiles:c1(c(cccc1)C)C
2. InChI:InChI=1/C8H10/c1-7-5-3-4-6-8(7)2/h3-6H,1-2H3

Toxicity:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human LCLo inhalation 6125ppm/12H (6125ppm)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 883, 1980.
mammal (species unspecified) LDLo intraperitoneal 1500mg/kg (1500mg/kg)   Journal of Pathology and Bacteriology. Vol. 46, Pg. 95, 1938.
mammal (species unspecified) LDLo subcutaneous 2500mg/kg (2500mg/kg)   Journal of Pathology and Bacteriology. Vol. 46, Pg. 95, 1938.
mouse LCLo inhalation 30gm/m3 (30000mg/m3) BEHAVIORAL: GENERAL ANESTHETIC

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

CARDIAC: OTHER CHANGES
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 143, Pg. 223, 1929.
mouse LD50 intraperitoneal 1550uL/kg (1.55mL/kg)   Archives of Toxicology. Vol. 58, Pg. 106, 1985.
rat LCLo inhalation 6125ppm/12H (6125ppm)   Journal of Pathology and Bacteriology. Vol. 46, Pg. 95, 1938.
rat LDLo oral 5gm/kg (5000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 883, 1980.

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