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1,3-Benzodioxole-5-ethanamine
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Name

1,3-Benzodioxole-5-ethanamine

 EINECS 216-060-8
CAS No. 1484-85-1 Density 1.204 g/c3
PSA 44.48000 LogP 1.61680
Solubility N/A Melting Point 114 °C
Formula C9H11NO2 Boiling Point 274.3 ºCat 760 mmHg
Molecular Weight 165.192 Flash Point 129.8 ºC
Transport Information N/A Appearance Colourless Liquid
Safety 26-39-24/25 Risk Codes 41
Molecular Structure Molecular Structure of 1484-85-1 (HOMOPIPERONYLAMINE) Hazard Symbols Xi
Synonyms

Phenethylamine,3,4-(methylenedioxy)- (7CI,8CI);2-(3,4-Methylenedioxyphenyl)ethylamine;2-(Benzo[d][1,3]dioxol-5-yl)ethanamine;2-Benzo[1,3]dioxol-5-yl-ethylamine;2-Benzo[1,3]dioxol-5-ylethanamine;3,4-(Methylenedioxy)-b-phenethylamine;3,4-(Methylenedioxy)phenethylamine;3,4-(Methylenedioxy)phenylethylamine;5-(2-Aminoethyl)benzodioxole;Homopiperonylamine;[2-(Benzodioxol-5-yl)ethyl]amine;

Article Data 87

1,3-Benzodioxole-5-ethanamine Synthetic route

1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

1484-85-1

3,4-methylenedioxyphenylethylamine

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran at 20 - 70℃; for 4h;100%
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 4h;95%
With diisobutylaluminium hydride In 1,4-dioxane at 60℃; for 3h;82%
550358-40-2

benzyl N-[2-(benzo[1,3]dioxol-5-yl)ethyl]carbamate

1484-85-1

3,4-methylenedioxyphenylethylamine

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In tetrahydrofuran; methanol at 20℃; under 760 Torr; for 3h;100%

C9H9NO2

1484-85-1

3,4-methylenedioxyphenylethylamine

Conditions
ConditionsYield
With hydrogen In ethanol at 70℃; under 112511 Torr; for 6h; Green chemistry;95.6%
1485-00-3, 22568-48-5

5-((E)-2-nitroethenyl)-1,3-benzodioxole

1484-85-1

3,4-methylenedioxyphenylethylamine

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at 0 - 70℃; for 12h; Inert atmosphere;95%
With lithium aluminium tetrahydride In tetrahydrofuran Reflux;87%
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; Reflux;84%
4439-02-5

3,4-methylenedioxyphenylacetonitrile

1484-85-1

3,4-methylenedioxyphenylethylamine

Conditions
ConditionsYield
With lithium aluminium tetrahydride; aluminium trichloride In diethyl ether for 2h;92%
With diisobutylaluminium hydride In tetrahydrofuran at 60℃; for 3h; Product distribution; other solvent, temp., time, reagent;80%
With diisobutylaluminium hydride In tetrahydrofuran at 60℃; for 3h;80%
20799-84-2

3-(benzo[d][1,3]dioxol-5-yl)propanamide

1484-85-1

3,4-methylenedioxyphenylethylamine

Conditions
ConditionsYield
With chlorine; sodium hydroxide In water at -5 - 40℃; for 4h; Reagent/catalyst; Temperature;91%
With chlorine; sodium hydroxide at 30 - 75℃; for 2h; Green chemistry;90%
With sodium hydroxide; bromine In water at 70 - 80℃; for 0.25h;71%
With sodium hypochlorite at 70 - 80℃;
21473-47-2

5-(2-nitroethyl)benzo[1,3]dioxole

1484-85-1

3,4-methylenedioxyphenylethylamine

Conditions
ConditionsYield
With lithium aluminium tetrahydride75%
With hydrogenchloride; iron In methanol; water for 0.5h; Heating;71%
With hydrogenchloride; zinc
With hydrogenchloride; zinc In ethanol; water for 3h;

5-(2-nitro-1(Z)-ethenyl)benzo[d][1,3]dioxol

1484-85-1

3,4-methylenedioxyphenylethylamine

Conditions
ConditionsYield
With hydrogenchloride; iron In methanol; water for 0.5h; Heating;70%
153361-93-4

benzo[1,3]dioxol-5-yl-acetaldehyde-oxime

1484-85-1

3,4-methylenedioxyphenylethylamine

Conditions
ConditionsYield
With sodium amalgam; acetic acid
With ethanol; calcium
With ethanol; sodium
119798-32-2

α-acetoxy-2-(3,4-methylenedioxyphenyl)acetonitrile

1484-85-1

3,4-methylenedioxyphenylethylamine

Conditions
ConditionsYield
With methanol; palladium; acetic acid Hydrogenation.Zusatz von wenig Salzsaeure;
With sulfuric acid; palladium; acetic acid Hydrogenation;

1,3-Benzodioxole-5-ethanamine Chemical Properties

The Molecular Structure of 1,3-Benzodioxole-5-ethanamine (CAS NO.1484-85-1):

Empirical Formula: C9H11NO2
Molecular Weight: 165.1891 
EINECS: 216-060-8
IUPAC Name: 2-(1,3-Benzodioxol-5-yl)ethanamine
Appearance: Colourless Liquid
Product Categories: Pharmaceutical Intermediates; Intermediates
Nominal Mass: 165
Average Mass: 165.1891
Monoisotopic Mass: 165.078979
Index of Refraction: 1.577
Molar Refractivity: 45.49 cm3
Molar Volume: 137.1 cm3
Surface Tension: 52 dyne/cm
Density: 1.204 g/cm3
Flash Point: 129.8 °C
Enthalpy of Vaporization: 51.27 kJ/mol
Boiling Point: 274.3 °C at 760 mmHg
Vapour Pressure: 0.00543 mmHg at 25 °C

1,3-Benzodioxole-5-ethanamine Uses

 1,3-Benzodioxole-5-ethanamine (CAS NO.1484-85-1) is used as an intermediate in the synthesis of pharmaceutical actives and other fine chemicals.

1,3-Benzodioxole-5-ethanamine Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LDLo intraperitoneal 300mg/kg (300mg/kg) BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION		 Journal of Physiology. Vol. 76, Pg. 224, 1932.

1,3-Benzodioxole-5-ethanamine Specification

 1,3-Benzodioxole-5-ethanamine (CAS NO.1484-85-1) is called as 2-(3,4-(Methylendioxy)phenyl)ethylamine ; 2-(3',4'-Methylenedioxy-phenyl)ethylamine ; 3,4-mde ; 3,4-Methylenedioxyphenethylamine ; 3,4-(Methylenedioxyphenyl)ethylamine ; Dl-mdea ; Homopiperonylamine .

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