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Cas Database

Name	1-Dimethylamino-2-propanol	EINECS	203-556-4
CAS No.	108-16-7	Density	0.888 g/cm³
PSA	23.47000	LogP	-0.07120
Solubility	miscible with water	Melting Point	-85 °C
Formula	C₅H₁₃NO	Boiling Point	123.999 °C at 760 mmHg
Molecular Weight	103.164	Flash Point	25.556 °C
Transport Information	UN 2734 8/PG 2	Appearance	light yellow liquid
Safety	26-36/37/39-45-36-23	Risk Codes	10-22-34
Molecular Structure		Hazard Symbols	C
Synonyms	1-(Dimethylamino)-2-propanol;1-Methyl-2-(dimethylamino)ethanol;2-(Dimethylamino)-1-methyl-1-ethanol;2-(Dimethylamino)-1-methylethanol;3-(Dimethylamino)-2-propanol;Bisomer Amine D 700;DL-1-(Dimethylamino)-2-propanol;Dimepranol;Dimethyl(2-hydroxypropyl)amine;Dimethylisopropanolamine;N,N-Dimethyl-2-hydroxy-1-propanamine;N,N-Dimethyl-2-hydroxypropylamine;N,N-Dimethylamino-2-propanol;N,N-Dimethylisopropanolamine;NSC 3163;	Article Data	28

1-Dimethylamino-2-propanol Synthetic route

: 124-40-3
dimethyl amine

: 75-56-9, 16033-71-9
methyloxirane

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

Conditions

Conditions	Yield
With diisopropanolamine at 70℃; under 5250.53 Torr; for 3h; Reagent/catalyst; Pressure; Temperature;	99.6%
With methanol at 60℃;
In ethanol Heating;

: 50-00-0
formaldehyd

: 78-96-6, 1674-56-2
3-amino-2-propanol

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

Conditions

Conditions	Yield
With formic acid for 24h; Heating;	60%

: 5909-67-1
tetramethyldiamidothiophosphoric acid

: 75-56-9, 16033-71-9
methyloxirane

A: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

B: 5843-26-5
tetramethylphosphorodiamidous acid

C: 83296-07-5
2-oxo-2-dimethylamino-4-methyl-1,3,2-thiaoxaphospholane

Conditions

Conditions	Yield
In 1,4-dioxane at 100 - 110℃; for 4h;	A n/a B n/a C 20%

: 1207286-38-1
1,1-dimethyl-1-(2-hydroxypropyl)amine benzoylformimide

A: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

B: 860223-18-3
2,3-dihydroxy-2,3-diphenyl-succinic acid diamide

Conditions

Conditions	Yield
In methanol at 20 - 30℃; for 0.833333h; UV-irradiation;	A n/a B 10%

: 19686-73-8
1-bromo-2-propanol

: 124-40-3
dimethyl amine

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

Conditions

Conditions	Yield
With benzene at 125℃;

: 124-40-3
dimethyl amine

: 127-00-4
1-Chloro-2-propanol

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

Conditions

Conditions	Yield
With sodium hydroxide at 40℃;
With toluene at 95 - 100℃;
at 100℃;
With sodium hydroxide at 40℃;

: 50-00-0
formaldehyd

: 64-18-6
formic acid

: 78-96-6, 1674-56-2
3-amino-2-propanol

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

Conditions

Conditions	Yield
With water

: 15364-56-4
dimethylaminoacetone

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether
(reduction);

: 124763-29-7
C13H18(125)INO3

A: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

B: p-(125I)iodophenoxyacetic acid

Conditions

Conditions	Yield
With phosphate buffer at 37℃; for 0.0833333h; chemical stability to hydrolysis; var.: time;

Ru[(-)-BINAP](OCOCH3)2: Ru[(-)-BINAP](OCOCH3)2

: 15364-56-4
dimethylaminoacetone

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

Conditions

Conditions	Yield
With nitrogen In methanol; dichloromethane

1-Dimethylamino-2-propanol Chemical Properties

IUPAC Name: 1-Dimethylamino-2-propanol
The MF of 1-Dimethylamino-2-propanol (108-16-7) is C₅H₁₃NO.

The MW of 1-Dimethylamino-2-propanol (108-16-7) is 103.16.
Synonyms of 1-Dimethylamino-2-propanol (108-16-7): 1-(Dimethylamino)-2-propano ; 1,1-Dimethylaminopropan-2-ol ; 1-Dimethylaminopropan-2-ol ; 1-N,N-Dimethylin-2-propanolamine ; 2-Propanol,1,1-(dimethylamino)- ; Dimethyl(2-hydroxypropyl)amine
Stability: Stable. Flammable. Incompatible with strong oxidizing agents, amines, acids
Form: light yellow liquid
Index of Refraction: 1.436
EINECS: 203-556-4
Density: 0.887 g/ml
Flash Point: 25.6 °C
Boiling Point: 124 °C
Melting Point: -85 °C
Storage temp: Flammables area
Water Solubility: miscible

1-Dimethylamino-2-propanol Uses

1-Dimethylamino-2-propanol (108-16-7) is used for the pharmaceutical industry, also used as a stabilizer of acrylonitrile polymer.

1-Dimethylamino-2-propanol Production

Hydrochloric acid---Sodium hydroxide---Diethyl ether---Formaldehyde---Formic acid---Amino-2-propanol

1-Dimethylamino-2-propanol Toxicity Data With Reference

1.	skn-rbt 10 mg/24H MLD	AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. 10 (1954),61.
2.	skn-rbt 500 mg MOD	FCTOD7 Food and Chemical Toxicology. 20 (1982),563.
3.	eye-rbt 250 µg SEV	AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. 10 (1954),61.
4.	eye-rbt 100 mg/4S rns SEV	FCTOD7 Food and Chemical Toxicology. 20 (1982),573.
5.	orl-rat LD50:1890 mg/kg	AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. 10 (1954),61.

1-Dimethylamino-2-propanol Consensus Reports

Reported in EPA TSCA Inventory.

1-Dimethylamino-2-propanol Safety Profile

Moderately toxic by ingestion. A skin and severe eye irritant. Used in boiler water condensate corrosion control. Dangerous fire hazard when exposed to heat or flame. Can react vigorously with oxidizers. To fight fire, use foam, CO₂, dry chemical. When heated to decomposition it emits toxic fumes of NO_x. See also AMINES.Safety information of 1-Dimethylamino-2-propanol (108-16-7):
Hazard Codes C
Risk Statements
10 Flammable
22 Harmful if swallowed
34 Causes burns
Safety Statements
26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39 Wear suitable protective clothing, gloves and eye/face protection
45 In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
23 Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer)
RIDADR UN 2734 8/PG 2
WGK Germany 1
RTECS UB3150000
F 10-34
HazardClass 8
PackingGroup II
HS Code 29221980

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