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1-Ethylpiperazine

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Name

1-Ethylpiperazine

EINECS 226-166-6
CAS No. 5308-25-8 Density 0.895 g/cm3
PSA 15.27000 LogP 0.17820
Solubility soluble in water Melting Point -60 °C
Formula C6H14 N2 Boiling Point 156 °C at 760 mmHg
Molecular Weight 114.191 Flash Point 53 °C
Transport Information UN 1993 3/PG 3 Appearance clear colorless to yellow liquid
Safety 26-36 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 5308-25-8 (1-Ethylpiperazine) Hazard Symbols IrritantXi
Synonyms

N-Ethylpiperazin;N-Ethylpiperazine;NSC 60707;

Article Data 37

1-Ethylpiperazine Synthetic route

C11H22N2O2

5308-25-8

4-ethylpiperazine

Conditions
ConditionsYield
With trifluoroacetic acid at 20℃; for 0.0833333h;94%
110-85-0

piperazine

75-00-3

chloroethane

A

5308-25-8

4-ethylpiperazine

B

6483-50-7

1,4-diethylpiperazine

Conditions
ConditionsYield
A 20%
B 55%
21863-75-2

4-ethyl-1-formylpiperazine

5308-25-8

4-ethylpiperazine

Conditions
ConditionsYield
With hydrogenchloride
74-96-4

ethyl bromide

7542-23-6

piperazine hydrochloride

5308-25-8

4-ethylpiperazine

Conditions
ConditionsYield
With ethanol
98951-41-8

4-ethyl-piperazine-1-carboxylic acid ethyl ester

5308-25-8

4-ethylpiperazine

Conditions
ConditionsYield
With hydrogen bromide; acetic acid
With hydrogenchloride
24426-42-4

EtN(CH2CN)2

5308-25-8

4-ethylpiperazine

Conditions
ConditionsYield
With nickel; platinum; benzene at 44℃; Hydrogenation;
557-66-4

ethanamine hydrochloride

10024-89-2

morpholin hydrochloride

5308-25-8

4-ethylpiperazine

Conditions
ConditionsYield
at 265℃;
at 265℃;
660-68-4

diethyl amine hydrochloride

10024-89-2

morpholin hydrochloride

5308-25-8

4-ethylpiperazine

Conditions
ConditionsYield
at 250℃;

1-benzyl-4-ethylpiperazine dihydrochloride

5308-25-8

4-ethylpiperazine

Conditions
ConditionsYield
With palladium on activated charcoal Hydrogenation;
821-48-7

bis-(2-chloroethyl)amine hydrochloride

75-04-7

ethylamine

5308-25-8

4-ethylpiperazine

Conditions
ConditionsYield
at 130℃;

1-Ethylpiperazine Chemical Properties

IUPAC Name:1-ethylpiperazine
Molecular Formula:C6H14N2
Molecular Weight:114.188760 g/mol
Appearance:clear, colorless liquid
Melting Point:-60 °C
Boiling Point:157 °C(lit.)
Flash Point:110 °F
density:0.899 g/mL at 25 °C(lit.)
refractive index:n20/D 1.469(lit.)
storage temp.:flammables area 
Water Solubility:soluble
Sensitive:Air
BRN:102971
EINECS:226-166-6
Synonyms of N-ethyl Piperazine(5308-25-8):
1-ethyl-piperazin;Piperazine, 1-ethyl-;ETHYLPIPERAZINE-N;LABOTEST-BB LTBB000704;1-ETHYLPIPERAZINE;AKOS BBS-00003610;N-ETHYLPIPERAZINE;NEPRZ;1-Ethylpiperazine
Categories of N-ethyl Piperazine(5308-25-8):
Piperidines,Piperidones,Piperazines;Piperaizine;Piperazines;Building Blocks;Heterocyclic Building Blocks

1-Ethylpiperazine Uses

N-ethyl Piperazine(5308-25-8) is used as an intermediate for veterinary medicine mainly used in the production of ciproflmoxacin ethyl.
N-ethyl Piperazine(5308-25-8) is also used as a raw material for the production of dyes and plant protection agents.

1-Ethylpiperazine Toxicity Data With Reference

Toxicity Information of N-ethyl Piperazine(5308-25-8):
1.rat LC50 inhalation > 9219mg/m3/4H (9219mg/m3)
SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION International Journal of Toxicology. Vol. 16
2.rat LD50 oral 2158mg/kg (2158mg/kg)
LUNGS, THORAX, OR RESPIRATION: PULMONARY EMBOLI
GASTROINTESTINAL: NAUSEA OR VOMITING
GASTROINTESTINAL: OTHER CHANGES
International Journal of Toxicology. Vol. 16

1-Ethylpiperazine Safety Profile

Safety Information of N-ethyl Piperazine(5308-25-8):
Hazard Codes:Xi
Risk Statements:36/37/38
36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements:26-36
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:Wear suitable protective clothing
RIDADR:UN 1993 3/PG 3
WGK Germany:1
RTECS:TM0815500
F:10-34
HazardClass:3
PackingGroup:III
HS Code:29335995

1-Ethylpiperazine Specification

First Aid Measures of N-ethyl Piperazine(5308-25-8):
Ingestion:Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:Get medical aid immediately. Remove from exposure to fresh air immediately. Do not use mouth-to-mouth respiration if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
Skin:Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
Eyes:Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub or keep eyes closed. Extensive irrigation is required (at least 30 minutes).

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