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2-[2-(2-Methoxyethoxy)ethoxy]acetic acid

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Name

2-[2-(2-Methoxyethoxy)ethoxy]acetic acid

EINECS 240-162-1
CAS No. 16024-58-1 Density 1.129 g/cm3
PSA 64.99000 LogP -0.24940
Solubility N/A Melting Point N/A
Formula C7H14O5 Boiling Point 295.214 °C at 760 mmHg
Molecular Weight 178.185 Flash Point 116.711 °C
Transport Information N/A Appearance COA
Safety 26-36/37/39-45 Risk Codes 34
Molecular Structure Molecular Structure of 16024-58-1 (2-[2-(2-METHOXYETHOXY)ETHOXY]ACETIC ACID) Hazard Symbols CorrosiveC
Synonyms

Aceticacid, [2-(2-methoxyethoxy)ethoxy]- (8CI,9CI);(Methoxyethoxy)ethoxyacetic acid;3,6,9-Trioxadecanoic acid;8-Methoxy-3,6-dioxaoctanoic acid;[2-(2-Methoxyethoxy)ethoxy]acetic acid;

Article Data 16

2-[2-(2-Methoxyethoxy)ethoxy]acetic acid Synthetic route

112-35-6

triethylene glucol monomethyl ether

16024-58-1

2-[2-(2-methoxyethoxy)etoxy]acetic acid

Conditions
ConditionsYield
With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hydrogencarbonate; sodium carbonate at 20℃; Electrochemical reaction;99%
Stage #1: triethylene glucol monomethyl ether With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; sodium carbonate at 20℃; for 2h; aq. buffer; Electroliysis;
Stage #2: With Amberlite IR 120 for 0.5h; Mechanism; Solvent; Temperature; aq. buffer;
99%
Stage #1: triethylene glucol monomethyl ether With C29H44Cl2N2Ru; sodium hydroxide In water for 24h; Reflux;
Stage #2: With hydrogenchloride In water
88%
79-11-8

chloroacetic acid

sodium compound of diethylene glycol-monoethyl ether

sodium compound of diethylene glycol-monoethyl ether

16024-58-1

2-[2-(2-methoxyethoxy)etoxy]acetic acid

Conditions
ConditionsYield
With diethyl ether
862072-76-2

bicyclo[2.2.1]hept-5-ene-2-carboxylic acid 2-[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]acetoxy}ethoxy)ethoxy]ethyl ester

A

16024-58-1

2-[2-(2-methoxyethoxy)etoxy]acetic acid

B

27063-48-5, 34733-86-3, 37750-50-8, 117835-14-0, 143916-13-6

bicyclo[2.2.1]hept-2-ene-5-carbonyl chloride

C

112-27-6

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

Conditions
ConditionsYield
With phosphate-buffered saline at 80℃; pH=7.4; Kinetics; Further Variations:; pH-values; Temperatures;
CC-4 silica gel

CC-4 silica gel

112-35-6

triethylene glucol monomethyl ether

16024-58-1

2-[2-(2-methoxyethoxy)etoxy]acetic acid

Conditions
ConditionsYield
With hydrogenchloride; sodium hydrogencarbonate In water
1252661-82-7

p-nitrophenyl 2-[2-(2-methoxyethoxy)ethoxy]acetate

A

100-02-7

4-nitro-phenol

B

16024-58-1

2-[2-(2-methoxyethoxy)etoxy]acetic acid

Conditions
ConditionsYield
With 6-{N-[6-(6-deoxy-α-cyclodextrinylthio)acetyl]-L-histidylamino}-6-deoxy-β-cyclodextrin at 25℃; pH=7.4; Kinetics; aq. phosphate buffer;
1252661-81-6

m-nitrophenyl 2-[2-(2-methoxyethoxy)ethoxy]acetate

A

16024-58-1

2-[2-(2-methoxyethoxy)etoxy]acetic acid

B

554-84-7

meta-nitrophenol

Conditions
ConditionsYield
With 6-{N-[6-(6-deoxy-α-cyclodextrinylthio)acetyl]-L-histidylamino}-6-deoxy-β-cyclodextrin at 25℃; pH=7.4; Kinetics; aq. phosphate buffer;
C11H22O5

C11H22O5

16024-58-1

2-[2-(2-methoxyethoxy)etoxy]acetic acid

Conditions
ConditionsYield
With methoxybenzene; trifluoroacetic acid In dichloromethane at 20℃; for 5h;
With methoxybenzene; trifluoroacetic acid In dichloromethane at 20℃; for 5h;
With trifluoroacetic acid In dichloromethane at 20℃;400 mg
111-77-3

2-(2-methoxyethoxy)ethyl alcohol

16024-58-1

2-[2-(2-methoxyethoxy)etoxy]acetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium tert-butylate / tert-butyl alcohol / 2 h / 20 °C
1.2: 12 h / 20 °C
2.1: trifluoroacetic acid; methoxybenzene / dichloromethane / 5 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium hydride / tetrahydrofuran / 3 h / 20 - 25 °C / Cooling with ice
2: trifluoroacetic acid / dichloromethane / 20 °C
View Scheme
16024-58-1

2-[2-(2-methoxyethoxy)etoxy]acetic acid

29022-11-5

N-(fluoren-9-ylmethoxycarbonyl)glycine

881027-71-0

[2-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-acetylamino}-acetylamino)-acetylamino]-acetic acid

Conditions
ConditionsYield
Stage #1: N-(fluoren-9-ylmethoxycarbonyl)glycine With N-ethyl-N,N-diisopropylamine In dichloromethane solid phase reaction;
Stage #2: With piperidine In N,N-dimethyl-formamide solid phase reaction;
Stage #3: 2-[2-(2-methoxyethoxy)etoxy]acetic acid Further stages;
100%

tetrakis(acetato)diaquadicopper(II)

16024-58-1

2-[2-(2-methoxyethoxy)etoxy]acetic acid

copper(II) 2-[2-(2-methoxyethoxy)ethoxy]acetate

Conditions
ConditionsYield
In toluene100%

2-[2-(2-Methoxyethoxy)ethoxy]acetic acid Specification

The Acetic acid,2-[2-(2-methoxyethoxy)ethoxy]- is an organic compound with the formula C7H14O5. The IUPAC name of this chemical is 2-[2-(2-Methoxyethoxy)ethoxy]acetic acid. With the CAS registry number 16024-58-1, it is also named as (2-(2-Methoxyethoxy)ethoxy)essigsure. The product's category is Heterocyclic Compounds. Besides, it should be stored in a cool, sealed, dry place.

Physical properties about Acetic acid,2-[2-(2-methoxyethoxy)ethoxy]- are: (1)ACD/LogP: -1.38; (2)ACD/LogD (pH 5.5): -3.48; (3)ACD/LogD (pH 7.4): -4.93; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 5; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 8; (11)Polar Surface Area: 53.99 Å2; (12)Index of Refraction: 1.436; (13)Molar Refractivity: 41.27 cm3; (14)Molar Volume: 157.7 cm3; (15)Polarizability: 16.36×10-24 cm3; (16)Surface Tension: 37.8 dyne/cm; (17)Density: 1.129 g/cm3; (18)Flash Point: 116.7 °C; (19)Enthalpy of Vaporization: 58.84 kJ/mol; (20)Boiling Point: 295.2 °C at 760 mmHg; (21)Vapour Pressure: 0.000376 mmHg at 25 °C.

Preparation: this chemical can be prepared by 2-[2-(2-Methoxy-ethoxy)-ethoxy]-ethanol. This reaction will need reagents Potassium hydroxide; Potassium permanganate, and solvent H2O. The reaction time is 12 hours. The yield is about 75%.

Uses of Acetic acid,2-[2-(2-methoxyethoxy)ethoxy]-: it can be used to produce 2-{2-[2-(2-Methoxy-ethoxy)-ethoxy]-acetylamino}-pentanedioic acid bis-octylamide. It will need reagents Et3N; Benzotriazole-1-yl-oxy-tris(dimethylamino)-phosphoniumhexafluorophosphate and solvent Acetone with reaction time of 12 hours. The yield is about 65%.

When you are using this chemical, please be cautious about it as the following:
It causes burns. When you are using it, wear suitable protective clothing, gloves and eye/face protection. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. In case of accident or if you feel unwell, seek medical advice immediately (show label where possible).

You can still convert the following datas into molecular structure:
(1)InChI: InChI=1/C7H14O5/c1-10-2-3-11-4-5-12-6-7(8)9/h2-6H2,1H3,(H,8,9)
(2)InChIKey: YHBWXWLDOKIVCJ-UHFFFAOYAS
(3)Std. InChI: InChI=1S/C7H14O5/c1-10-2-3-11-4-5-12-6-7(8)9/h2-6H2,1H3,(H,8,9)
(4)Std. InChIKey: YHBWXWLDOKIVCJ-UHFFFAOYSA-N

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