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Name |
2-(2-Ethoxyphenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one |
EINECS | 607-089-0 |
CAS No. | 224789-21-3 | Density | 1.266 g/cm3 |
PSA | 72.28000 | LogP | 2.74420 |
Solubility | 6.9mg/L at 20℃ | Melting Point |
198-200 °C |
Formula | C17H20N4O2 | Boiling Point | 519.699 °C at 760 mmHg |
Molecular Weight | 312.371 | Flash Point | 268.105 °C |
Transport Information | N/A | Appearance | Pale yellow solid |
Safety | Risk Codes | N/A | |
Molecular Structure | Hazard Symbols | N/A | |
Synonyms |
2-(2-Ethoxyphenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one; |
Article Data | 9 |
N-{1-[3-(2-ethoxyphenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}butyroamide
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
Conditions | Yield |
---|---|
With trichlorophosphate In toluene for 2h; Reflux; | 78% |
With trichlorophosphate | |
With trichlorophosphate In 1,2-dichloro-ethane for 2h; Reflux; | |
With trichlorophosphate In 1,2-dichloro-ethane for 2h; Reflux; |
3-(2-ethoxy-benzoylamino)-5-methyl-2-propyl-3H-imidazole-4-carboxamide
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
Conditions | Yield |
---|---|
With potassium tert-butylate In tert-butyl alcohol at 160℃; for 30h; | 72% |
With potassium tert-butylate In tert-butyl alcohol at 160℃; for 30h; Sealed tube; | 72% |
5-methyl-2-propyl-3H-imidazole-4-carboxamide
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: lithium hexamethyldisilazane / dimethylformamide; tetrahydrofuran / 0.17 h / -10 °C 1.2: 41 percent / Ph2P(O)ONH2 / tetrahydrofuran; dimethylformamide / 20 °C 2.1: 52 percent / pyridine / 2 h / 60 °C 3.1: 72 percent / KOtBu / 2-methyl-propan-2-ol / 30 h / 160 °C View Scheme |
3-amino-5-methyl-2-propyl-3H-imidazole-4-carboxamide
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 52 percent / pyridine / 2 h / 60 °C 2: 72 percent / KOtBu / 2-methyl-propan-2-ol / 30 h / 160 °C View Scheme |
ethyl 5-methyl-2-propyl-3H-imidazole-4-carboxylate
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: 53 percent / ammonium hydroxide / 24 h / 130 °C 2.1: lithium hexamethyldisilazane / dimethylformamide; tetrahydrofuran / 0.17 h / -10 °C 2.2: 41 percent / Ph2P(O)ONH2 / tetrahydrofuran; dimethylformamide / 20 °C 3.1: 52 percent / pyridine / 2 h / 60 °C 4.1: 72 percent / KOtBu / 2-methyl-propan-2-ol / 30 h / 160 °C View Scheme |
2-butyrylaminopropionic acid
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: Py; DMAP 2: POCl3 View Scheme | |
Multi-step reaction with 3 steps 1.1: dmap; pyridine / tetrahydrofuran / 4 h / Reflux 2.1: hydrazine hydrate / ethanol / 20 °C 2.2: 3.25 h / Reflux 3.1: trichlorophosphate / 1,2-dichloro-ethane / 2 h / Reflux View Scheme | |
Multi-step reaction with 3 steps 1: dmap; pyridine / tetrahydrofuran / 4 h / Reflux 2: ethanol / 3 h / Reflux 3: trichlorophosphate / 1,2-dichloro-ethane / 2 h / Reflux View Scheme |
2-ethoxybenzonitrile
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: AlMeClNH2 2: N2H4 3: POCl3 View Scheme | |
Multi-step reaction with 3 steps 1.1: trimethylaluminum; ammonium chloride / toluene / 7 h / 0 - 80 °C 2.1: hydrazine hydrate / ethanol / 20 °C 2.2: 3.25 h / Reflux 3.1: trichlorophosphate / 1,2-dichloro-ethane / 2 h / Reflux View Scheme | |
Multi-step reaction with 4 steps 1.1: amino(methyl)aluminum chloride / toluene / 6 h / 80 °C 2.1: hydrazine hydrate / ethanol / 20 °C 2.2: Reflux 3.1: ethanol / 3 h / Reflux 4.1: trichlorophosphate / 1,2-dichloro-ethane / 2 h / Reflux View Scheme |
2-ethoxy-benzamidine hydrochloride
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: N2H4 2: POCl3 View Scheme |
ethyl 3-butyramido-2-oxobutyrate
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: POCl3 View Scheme | |
Multi-step reaction with 2 steps 1.1: hydrazine hydrate / ethanol / 20 °C 1.2: 3.25 h / Reflux 2.1: trichlorophosphate / 1,2-dichloro-ethane / 2 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: ethanol / 3 h / Reflux 2: trichlorophosphate / 1,2-dichloro-ethane / 2 h / Reflux View Scheme |
2-ethoxybenzimidohydrazide
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: POCl3 View Scheme | |
Multi-step reaction with 2 steps 1: ethanol / 3 h / Reflux 2: trichlorophosphate / 1,2-dichloro-ethane / 2 h / Reflux View Scheme |
Systematic Name: 2-(2-Ethoxyphenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one
SMILES: O=C2/N=C(\Nn1c(nc(c12)C)CCC)c3ccccc3OCC
InChI: InChI=1/C17H20N4O2/c1-4-8-14-18-11(3)15-17(22)19-16(20-21(14)15)12-9-6-7-10-13(12)23-5-2/h6-7,9-10H,4-5,8H2,1-3H3,(H,19,20,22)
InChIKey: YRRWQMBIMZMVDB-UHFFFAOYAC
Empirical Formula: C17H20N4O2
Molecular Weight: 312.3663
Nominal Mass: 312
Average Mass: 312.3663
Monoisotopic Mass: 312.158626
H bond acceptors: 6
H bond donors: 1
Freely Rotating Bonds: 5
Index of Refraction: 1.632
Molar Refractivity: 88.049 cm3
Molar Volume: 246.814 cm3
Surface Tension: 45.786 dyne/cm
Density: 1.266 g/cm3
Flash Point: 268.105 °C
Enthalpy of Vaporization: 79.252 kJ/mol
Boiling Point: 519.699 °C at 760 mmHg
Vapour Pressure: 0 mmHg at 25 °C
Appearance: Pale Yellow Solid
Melting Point: 198-200 °C
Product Categories of 2-(2-Ethoxyphenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one (CAS NO.224789-21-3): Heterocyclic Compounds; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals
2-(2-Ethoxyphenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one (CAS NO.224789-21-3) is used as vardenafil intermediate.
2-(2-Ethoxyphenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one (CAS NO.224789-21-3), its Synonyms are 2-(2-Ethoxyphenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4-ol ; Imidazo[5,1-f][1,2,4]triazin-4(1H)-one, 2-(2-ethoxyphenyl)-5-methyl-7-propyl- ; 2-(2-Ethoxyphenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one .