Related Products
- 58861-53-3Pyridine,2-(4-fluorophenyl)-
- 58862-38-7Benzenesulfonic acid,2-(4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)-
- 588-63-6Benzene,(3-bromopropoxy)-
- 588-64-7Benzaldehyde,2-phenylhydrazone
- 58865-88-63-Hydroxy-1,6,10-phytatrien-9-one
- 58-86-6(D)-Xylose
- 588668-97-74H-1,3,2-Dithiazine,4,4,5,5,6,6-hexafluorodihydro-, 1,1,3,3-tetraoxide, potassium salt (1:1)
- 588676-07-7Methanone,[4-(2,5-dimethylphenyl)-1-piperazinyl](3-methyl-2-benzofuranyl)-
- 588702-62-92-Pyridinecarboxylicacid, 4-(trifluoromethyl)-
- 588702-66-33-(Trifluoromethyl)quinoline-8-carboxylic acid
Hot Products
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
- 7631-86-9Silicon dioxide
- 302-79-4Tretinoin
- 77-92-9Citric acid
|
Basic Information |
|
Post buying leads |
|
Suppliers |
|
Cas Database |
| Name |
2-(4-Fluorophenyl)thiophene |
EINECS | 611-756-1 |
| CAS No. | 58861-48-6 | Density | 1.201 g/cm3 |
| PSA | 28.24000 | LogP | 3.55420 |
| Solubility | N/A | Melting Point |
51.0 to 55.0 °C |
| Formula | C10H7FS | Boiling Point | 252.316 °C at 760 mmHg |
| Molecular Weight | 178.23 | Flash Point | 106.397 °C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Risk Codes | N/A | |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
2-(4-Fluorophenyl)thiophene; |
Article Data | 53 |
2-(4-Fluorophenyl)thiophene Synthetic route
Conditions
| Conditions | Yield |
|---|---|
| With Tedicyp; potassium carbonate; bis(η3-allyl-μ-chloropalladium(II)) In xylene at 130℃; for 20h; Suzuki cross-coupling reaction; | 95% |
| With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In N,N-dimethyl-formamide at 120℃; for 15h; Inert atmosphere; | 85% |
| With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,2-dimethoxyethane; water at 25 - 75℃; Inert atmosphere; | 82.5% |
- 1003-09-4
2-bromothiophene
- 352-13-6
4-flourophenylmagnesium bromide
- 58861-48-6
2-(4-fluorophenyl)thiophene
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 2-bromothiophene With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride In tetrahydrofuran at 2℃; for 0.666667h; Stage #2: 4-flourophenylmagnesium bromide In tetrahydrofuran at 10 - 23℃; for 1.66667h; Stage #3: With acetic acid In tetrahydrofuran; water at 7℃; for 0.75h; | 95% |
| Stage #1: 2-bromothiophene; 1,3-bis-(diphenylphosphino)propane; palladium diacetate In tetrahydrofuran at 50℃; for 0.0833333h; Inert atmosphere; Stage #2: 4-flourophenylmagnesium bromide In tetrahydrofuran at 60℃; for 7h; Stage #3: With hydrogenchloride In tetrahydrofuran; water at 30℃; Cooling with ice; |
Conditions
| Conditions | Yield |
|---|---|
| With potassium carbonate In water; N,N-dimethyl-formamide at 100℃; under 2585.81 Torr; for 0.333333h; Suzuki reaction; Microwave irradiation; | 94% |
| With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In Dimethyl ether; water at 100℃; for 0.5h; Microwave irradiation; | 86.1% |
| With potassium carbonate; Pd-N-heterocyclic carbene-organic silica In water; N,N-dimethyl-formamide at 100℃; for 0.16h; Suzuki reaction; microwave irradiation; | 91 % Chromat. |
Conditions
| Conditions | Yield |
|---|---|
| With potassium carbonate; tris-(dibenzylideneacetone)dipalladium(0); tricyclohexylphosphine In ethanol; water at 90℃; Inert atmosphere; | 92% |
| With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate In toluene at 90℃; for 0.5h; Schlenk technique; Inert atmosphere; | 92% |
| With C33H48Cl2N4O9Pd; oxygen; potassium carbonate In water at 80℃; Suzuki-Miyaura Coupling; | 85% |
| Stage #1: thiophene boronic acid; 1-Bromo-4-fluorobenzene With sodium carbonate In water; N,N-dimethyl-formamide at 20℃; for 0.166667h; Inert atmosphere; Stage #2: With tetrakis(triphenylphosphine) palladium(0) In water; N,N-dimethyl-formamide at 85℃; for 3.03333h; Inert atmosphere; | 82% |
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 1-Bromo-4-fluorobenzene With iodine; magnesium In tetrahydrofuran at 36 - 40℃; for 4h; Inert atmosphere; Stage #2: 2-bromothiophene With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride In tetrahydrofuran at 20 - 25℃; for 5h; Temperature; Solvent; Inert atmosphere; | 91.3% |
| Stage #1: 2-bromothiophene With magnesium In tetrahydrofuran at 30 - 45℃; Inert atmosphere; Stage #2: 1-Bromo-4-fluorobenzene With tetrakis(triphenylphosphine)nickel(0) In tetrahydrofuran at 60 - 80℃; for 6h; Inert atmosphere; Stage #3: With sulfuric acid In tetrahydrofuran; water at 40 - 60℃; pH=2.2; Reagent/catalyst; | 87.6% |
| Stage #1: 2-bromothiophene With magnesium In tetrahydrofuran at 30 - 45℃; for 2h; Inert atmosphere; Sealed tube; Stage #2: 1-Bromo-4-fluorobenzene With tetrakis(triphenylphosphine)nickel(0) In tetrahydrofuran at 60 - 80℃; for 6h; Kumada Cross-Coupling; Inert atmosphere; Stage #3: With water at 40 - 60℃; Reagent/catalyst; | 87.6% |
| Stage #1: 1-Bromo-4-fluorobenzene With magnesium In tetrahydrofuran; ethylene dibromide for 1.5h; Inert atmosphere; Stage #2: 2-bromothiophene With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) In tetrahydrofuran at 10 - 75℃; for 0.5h; | 75% |
| Stage #1: 1-Bromo-4-fluorobenzene With magnesium In 2-Me-THF Reflux; Inert atmosphere; Stage #2: 2-bromothiophene; 1,2-bis(diphenylphosphino)ethane nickel(II) chloride In 2-Me-THF at 2 - 22℃; Inert atmosphere; Stage #3: With acetic acid In 2-Me-THF; water for 0.25h; Inert atmosphere; |
Conditions
| Conditions | Yield |
|---|---|
| With potassium phosphate tribasic trihydrate; C31H41P; palladium diacetate In tetrahydrofuran at 110℃; for 3h; Suzuki-Miyaura Coupling; Inert atmosphere; | 91% |
| With C27H39Br2N3Pd; potassium hydroxide In isopropyl alcohol at 82℃; for 0.166667h; Suzuki-Miyaura Coupling; | 87% |
- 517867-11-7
1-ethoxythiocarbonylsulfanyl-4-(4-fluorophenyl)-4-oxobutyl 2,2-dimethylpropionate
- 58861-48-6
2-(4-fluorophenyl)thiophene
Conditions
| Conditions | Yield |
|---|---|
| With acetic acid; potassium iodide at 110℃; for 0.0833333h; Microwave irradiation; | 88% |
| Multi-step reaction with 2 steps 1: titanium tetrachloride / dichloromethane / 0 - 20 °C / Inert atmosphere 2: silica gel / neat (no solvent) / 215 °C / Inert atmosphere View Scheme |
Conditions
| Conditions | Yield |
|---|---|
| With tris-(dibenzylideneacetone)dipalladium(0); silver tetrafluoroborate In N,N-dimethyl-formamide at 80℃; for 16h; chemoselective reaction; | 88% |
- 1003-09-4
2-bromothiophene
- 214360-58-4
2-(4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
- 58861-48-6
2-(4-fluorophenyl)thiophene
Conditions
| Conditions | Yield |
|---|---|
| With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In Dimethyl ether; water at 70 - 75℃; | 87% |
Conditions
| Conditions | Yield |
|---|---|
| With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In water; N,N-dimethyl-formamide at 85℃; Inert atmosphere; | 86% |
| With tetrakis(triphenylphosphine) palladium(0) In water; N,N-dimethyl-formamide at 85℃; Inert atmosphere; | 86% |
| With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In water; N,N-dimethyl-formamide at 85℃; for 3h; | 86% |
2-(4-Fluorophenyl)thiophene Specification
The 2-(4-Fluorophenyl)thiophene with the CAS number 58861-48-6 is also called Thiophene,2-(4-fluorophenyl)-. Its molecular formula is C10H7FS. This chemical is a kind of organics. It should be stored in dry and cool environment.
The properties of the 2-(4-Fluorophenyl)thiophene are: (1)ACD/LogP: 3.83; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 4; (4)ACD/LogD (pH 7.4): 4; (5)ACD/BCF (pH 5.5): 391; (6)ACD/BCF (pH 7.4): 391; (7)ACD/KOC (pH 5.5): 2497; (8)ACD/KOC (pH 7.4): 2497; (9)#H bond acceptors: 0; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 28.24 Å2; (13)Index of Refraction: 1.578; (14)Molar Refractivity: 49.223 cm3; (15)Molar Volume: 148.407 cm3; (16)Polarizability: 19.513×10-24cm3; (17)Surface Tension: 39.02 dyne/cm; (18)Enthalpy of Vaporization: 46.986 kJ/mol; (19)Vapour Pressure: 0.031 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)SMILES: Fc1ccc(cc1)c2cccs2
(2)InChI: InChI=1/C10H7FS/c11-9-5-3-8(4-6-9)10-2-1-7-12-10/h1-7H
(3)InChIKey: PURJRGMZIKXDMW-UHFFFAOYAA
Post a RFQ
1
What can I do for you?
Get Best Price
Get Best Price for 58861-48-6
2-(4-FLUOROPHENYL)THIOPHENE
