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Name |
2'-O-Methylcytidine |
EINECS | 2017-001-1 |
CAS No. | 2140-72-9 | Density | 1.68 g/cm3 |
PSA | 119.83000 | LogP | -1.32770 |
Solubility | N/A | Melting Point |
252-253 °C |
Formula | C10H15N3O5 | Boiling Point | 506 °C at 760 mmHg |
Molecular Weight | 257.246 | Flash Point | 259.8 °C |
Transport Information | N/A | Appearance | N/A |
Safety | 26-36 | Risk Codes | 36/37/38 |
Molecular Structure | Hazard Symbols | Xi | |
Synonyms |
O2'-Methylcytidine;2'-OMe-C; |
Article Data | 36 |
3',5'-di-O-acetyl-2'-O-methylcytidine
2'-O-methylcytidine
Conditions | Yield |
---|---|
With ammonia In methanol at 20℃; | 99% |
3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disilyl)-2'-O-methylcytidine
2'-O-methylcytidine
Conditions | Yield |
---|---|
With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; | 96% |
N4-benzoyl-3',5'-di-O-benzoyl-2'-O-methylcytidine
2'-O-methylcytidine
Conditions | Yield |
---|---|
With ammonia In methanol at 4℃; for 48h; | 80% |
Conditions | Yield |
---|---|
In methanol for 5h; Reflux; | 76% |
diazomethane
CYTIDINE
A
3'-O-Methylcytidine
B
2'-O-methylcytidine
Conditions | Yield |
---|---|
With tin(ll) chloride In methanol; 1,2-dimethoxyethane for 0.333333h; Ambient temperature; | A 14% B 69% |
dibutyldimethoxytin In methanol Mechanism; | |
dibutyldimethoxytin In methanol |
trimethylsulphonium hydroxide
CYTIDINE
A
3'-O-Methylcytidine
B
2'-O-methylcytidine
C
N3-methylcytidine
Conditions | Yield |
---|---|
With copper acetylacetonate In N,N-dimethyl-formamide at 70℃; for 1h; | A 22% B 60% C 3% |
In N,N-dimethyl-formamide at 70℃; for 1h; | A 7% B 28% C 13% |
With copper acetylacetonate In N,N-dimethyl-formamide at 70℃; for 1h; Product distribution; without metallo-organic compound; | |
In methanol; N,N-dimethyl-formamide at 70℃; for 1h; Title compound not separated from byproducts; | A 7 % Spectr. B 28 % Spectr. C 13 % Spectr. |
In methanol; N,N-dimethyl-formamide at 70℃; Title compound not separated from byproducts; | A n/a B 28 % Spectr. C 13 % Spectr. |
trimethylsulphonium hydroxide
CYTIDINE
A
3'-O-Methylcytidine
B
2'-O-methylcytidine
Conditions | Yield |
---|---|
With magnesium(II) acetylacetonate In methanol; N,N-dimethyl-formamide at 70℃; for 1h; Product distribution; absence of metal ion; | A 2% B 43% |
With magnesium(II) acetylacetonate In methanol; N,N-dimethyl-formamide at 70℃; for 1h; | A 2% B 43% |
trimethylphenylammonium hydroxide
CYTIDINE
A
3-methyluridine
B
3'-O-Methylcytidine
C
2'-O-methylcytidine
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 100℃; | A n/a B 3 % Spectr. C 24% |
In N,N-dimethyl-formamide at 100℃; | A 22 % Spectr. B 4 % Spectr. C 21% |
1-methyl-1-nitrosourea
CYTIDINE
A
2'-O-methylcytidine
B
N3-methylcytidine
Conditions | Yield |
---|---|
With borax In water; formamide at 50℃; for 18h; | A 5% B n/a |
Conditions | Yield |
---|---|
With sodium hydride 1) DMF, 0 deg C, 45 min, 2a) 0 deg C, 2.5 h, 2b) r.t., 1 h; Multistep reaction. Yields of byproduct given; | |
With sodium hydride 1) DMF, 0 deg C, 45 min, 2a) 0 deg C, 2.5 h, 2b) r.t., 1 h; Yield given. Multistep reaction; |
The Cytidine, 2'-O-methyl-, with CAS registry number 2140-72-9, belongs to the following product categories: (1)Biochemicals and Reagents; (2)Nucleoside Analogs; (3)Nucleosides, Nucleotides, Oligonucleotides. It has the systematic name of 2'-O-methylcytidine. This chemical should be stored at the temperature of −20°C. And the chemical formula of this chemical is C10H15N3O5.
Physical properties of Cytidine, 2'-O-methyl-: (1)ACD/LogP: -1.09; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.09; (4)ACD/LogD (pH 7.4): -1.09; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 6.07; (8)ACD/KOC (pH 7.4): 6.1; (9)#H bond acceptors: 8; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 5; (12)Polar Surface Area: 72.83 Å2; (13)Index of Refraction: 1.677; (14)Molar Refractivity: 57.6 cm3; (15)Molar Volume: 152.8 cm3; (16)Polarizability: 22.83×10-24cm3; (17)Surface Tension: 68.4 dyne/cm; (18)Density: 1.68 g/cm3; (19)Flash Point: 259.8 °C; (20)Enthalpy of Vaporization: 89.33 kJ/mol; (21)Boiling Point: 506 °C at 760 mmHg; (22)Vapour Pressure: 2.33E-12 mmHg at 25°C.
When you are using this chemical, please be cautious about it as the following:
The Cytidine, 2'-O-methyl- irritates to eyes, respiratory system and skin. When use it, wear suitable protective clothing, gloves and eye/face protection. If contact with eyes, rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
(1)SMILES: O=C1/N=C(/N)\C=C/N1[C@@H]2O[C@@H]([C@@H](O)[C@H]2OC)CO
(2)InChI: InChI=1/C10H15N3O5/c1-17-8-7(15)5(4-14)18-9(8)13-3-2-6(11)12-10(13)16/h2-3,5,7-9,14-15H,4H2,1H3,(H2,11,12,16)/t5-,7-,8-,9-/m1/s1
(3)InChIKey: RFCQJGFZUQFYRF-ZOQUXTDFBZ
(4)Std. InChI: InChI=1S/C10H15N3O5/c1-17-8-7(15)5(4-14)18-9(8)13-3-2-6(11)12-10(13)16/h2-3,5,7-9,14-15H,4H2,1H3,(H2,11,12,16)/t5-,7-,8-,9-/m1/s1
(5)Std. InChIKey: RFCQJGFZUQFYRF-ZOQUXTDFSA-N