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2,2,2-Trifluoroethylamine hydrochloride
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Name

2,2,2-Trifluoroethylamine hydrochloride

 EINECS 206-771-1
CAS No. 373-88-6 Density 1.24 g/cm3
PSA 26.02000 LogP 2.00970
Solubility It is Soluble in 0.7 to water, but soluble in ethanol and chloroform, slightly soluble in benzene, hardly soluble in ether. Melting Point 220-222 °C (subl.)(lit.)
Formula C2H4F3N.HCl Boiling Point 36 °C at 760 mmHg
Molecular Weight 135.517 Flash Point 27.6oC
Transport Information N/A Appearance white to light yellow crystalline powder
Safety 36/37-24/25-26 Risk Codes 20/21/22-36/37/38
Molecular Structure Molecular Structure of 373-88-6 (2,2,2-Trifluoroethylamine hydrochloride) Hazard Symbols HarmfulXn, ToxicT, IrritantXi
Synonyms

Ethanamine,2,2,2-trifluoro-, hydrochloride (9CI);Ethylamine, 2,2,2-trifluoro-,hydrochloride (7CI,8CI);2,2,2-Trifluoro-1-ethanamine hydrochloride;2,2,2-Trifluoroethanamine hydrochloride;Trifluoroethylamine hydrochloride;

Article Data 4

2,2,2-Trifluoroethylamine hydrochloride Synthetic route

753-90-2

trifluoroethylamine

373-88-6

2,2,2-trifluroethylamine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water at 25 - 50℃; for 1h; Temperature;96.3%
100-46-9

benzylamine

76-05-1

trifluoroacetic acid

373-88-6

2,2,2-trifluroethylamine hydrochloride

Conditions
ConditionsYield
Stage #1: benzylamine; trifluoroacetic acid With tetrachloromethane; TEA; triphenylphosphine In chloroform at 80℃; for 0.666667h;
Stage #2: With TEA; water at 80℃; for 12h;
Stage #3: With hydrogenchloride In methanol for 12h; Heating;		94%

[1-Phenyl-meth-(E)-ylidene]-(2,2,2-trifluoro-ethyl)-amine

373-88-6

2,2,2-trifluroethylamine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In diethyl ether for 4h; Ambient temperature;87%
348-08-3

N-(2,2,2-trifluoroethyl)benzamide

373-88-6

2,2,2-trifluroethylamine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In methanol for 24h; Heating;
1631-26-1

1-benzyl-1H-pyrrole-2,5-dione

373-88-6

2,2,2-trifluroethylamine hydrochloride

1428147-22-1

3a,6a-dihydro-5-(phenylmethyl)-3-(trifluoromethyl)pyrrolo[3,4-c]pyrazole-4,6(1H,5H)-dione

Conditions
ConditionsYield
Stage #1: 2,2,2-trifluroethylamine hydrochloride With sodium nitrite In dodecane; water Inert atmosphere;
Stage #2: 1-benzyl-1H-pyrrole-2,5-dione In diethyl ether at 20℃; Inert atmosphere;		100%
500-22-1

3-pyridinecarboxaldehyde

373-88-6

2,2,2-trifluroethylamine hydrochloride

1424799-68-7

(pyridine-3-ylmethylene)(2,2,2-trifluoroethyl)amine

Conditions
ConditionsYield
With sodium hydroxide In water; toluene at 20℃; Cooling with ice;100%
With triethylamine In acetonitrile at 0 - 20℃; for 15h;84%
373-88-6

2,2,2-trifluroethylamine hydrochloride

35344-95-7

1H-pyrazole-4-carbaldehyde

1424799-64-3

(1H-pyrazol-4-ylmethylene)(2,2,2-trifluoroethyl)amine

Conditions
ConditionsYield
With sodium hydroxide In water; toluene at 20℃; Cooling with ice;100%
373-88-6

2,2,2-trifluroethylamine hydrochloride

79-04-9

chloroacetyl chloride

170655-44-4

2-chloro-N-(2,2,2-trifluoroethyl)acetamide

Conditions
ConditionsYield
Stage #1: 2,2,2-trifluroethylamine hydrochloride With tert-butyl methyl ether; sodium hydroxide In water at 20℃; for 0.5h;
Stage #2: chloroacetyl chloride at 5 - 10℃; for 1h;		100%
With potassium carbonate In dichloromethane; water at 0 - 30℃; for 3.16667h;87.2%
Stage #1: 2,2,2-trifluroethylamine hydrochloride With sodium hydroxide In tert-butyl methyl ether; water at 0℃; for 0.5h;
Stage #2: chloroacetyl chloride In tert-butyl methyl ether; water at 0℃; for 1h;		63%
Stage #1: 2,2,2-trifluroethylamine hydrochloride With sodium hydroxide In tert-butyl methyl ether; water at 0 - 5℃; for 0.5h;
Stage #2: chloroacetyl chloride In tert-butyl methyl ether; water at 5 - 10℃; for 1h;
622-97-9

1-ethenyl-4-methylbenzene

373-88-6

2,2,2-trifluroethylamine hydrochloride

(+/-)-1-methyl-4-((trans)-2-(trifluoromethyl)cyclopropyl)benzene

Conditions
ConditionsYield
With dmap; meso-tetraphenylporphyrin iron(III) chloride; sulfuric acid; sodium acetate; sodium nitrite In water at 20℃; for 14.0167h; Inert atmosphere; diastereoselective reaction;99%
With dmap; meso-tetraphenylporphyrin iron(III) chloride; sulfuric acid; sodium acetate; sodium nitrite In water for 14h; Inert atmosphere;
373-88-6

2,2,2-trifluroethylamine hydrochloride

922-67-8

propynoic acid methyl ester

6833-82-5

3-trifluoromethyl-1H-pyrazole-5-carboxylic acid methyl ester

Conditions
ConditionsYield
With sodium nitrite In dichloromethane; water at 0 - 20℃; for 24h;99%
With sodium nitrite In dichloromethane; water at 20℃; for 72h;
With sodium nitrite In dichloromethane; water at 0 - 20℃;

2,2,2-Trifluoroethylamine hydrochloride Chemical Properties

IUPAC Name: 2,2,2-Trifluoroethanamine hydrochloride
Synonyms  of Trifluoroethylamine hydrochloride (CAS NO.373-88-6): Trifluoroethylamine hydrochloride ; 2,2,2-Trifluoroethylamine hydrochloride ; 2,2,2-Trifluoro-ethyl-ammonium chloride ; 2-Amino-1,1,1-trifluoroethane hydrochloride ; 2,2,2-Trifluoro-ethanaminhydrochloride ; Trifluoro-ethylaminhydrochloride ; 2,2,2-Trifluoroethylaminehcl
CAS NO: 373-88-6 
Molecular Formula: C2H5ClF3N 
Molecular Weight: 135.52
Molecular Weight:
EINECS: 206-771-1
Mol File: 373-88-6.mol 
H bond acceptors: 1
H bond donors: 2
Freely Rotating Bonds: 1
Polar Surface Area: 3.24 Å2
Flash Point: 27.6 °C 
Density:  1,24g/cm3
Refractive index:  1,3-1,302
Sensitive : Hygroscopic
Enthalpy of Vaporization: 36.74 kJ/mol 
Boiling Point: 121.9 °C at 760 mmHg 
Melting point:  220-222 °C (subl.)(lit.)
Vapour Pressure: 13 mmHg at 25°C 
Appearance: white to light yellow crystalline powder
SMILES: Cl.FC(F)(F)CN
InChI: InChI=1/C2H4F3N.ClH/c3-2(4,5)1-6;/h1,6H2;1H
InChIKey: ZTUJDPKOHPKRMO-UHFFFAOYAV
Std. InChI: InChI=1S/C2H4F3N.ClH/c3-2(4,5)1-6;/h1,6H2;1H
Std. InChIKey: ZTUJDPKOHPKRMO-UHFFFAOYSA-N

2,2,2-Trifluoroethylamine hydrochloride Uses

 Trifluoroethylamine hydrochloride (CAS NO.373-88-6) is used as pharmaceutical intermediates.

2,2,2-Trifluoroethylamine hydrochloride Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 unreported 476mg/kg (476mg/kg)   "Fluorine Chemistry, Volume III. Biological Effects of Organic Fluorides," Simons, J.H., ed., New York, Academic Press, Inc., 1963Vol. 3, Pg. 81, 1963.

2,2,2-Trifluoroethylamine hydrochloride Safety Profile

Hazard Codes:  Xn,XiT
Risk Statements:  20/21/22-36/37/38
Vapour Pressure: 13 mmHg at 25°C
36/37/38: Irritating to eyes, respiratory system and skin .
Safety Statements:  36/37-24/25-26
36/37:  Irritating to eyes and respiratory system.
24/25:  Toxic in contact with skin and if swallowed.
26:  Very Toxic by inhalation.
WGK Germany: 3
RTECS: KS0250000
F: 3-10-21
Hazard Note:  Hygroscopic/Toxic
TSCA: T
PackingGroup:  III

2,2,2-Trifluoroethylamine hydrochloride Specification

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media: Use agent most appropriate to extinguish fire. 
Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Storage: Store Trifluoroethylamine hydrochloride (CAS NO.373-88-6) in a cool, dry place. Keep container closed when not in use.

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