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Cas Database |
| Name |
2(2-Ethoxyethoxy)ethanol |
EINECS | 203-919-7 |
| CAS No. | 111-90-0 | Density | 0.999 g/cm3 |
| PSA | 38.69000 | LogP | 0.03180 |
| Solubility | miscible with water | Melting Point |
-80 °C |
| Formula | C6H14O3 | Boiling Point | 202 °C at 760 mmHg |
| Molecular Weight | 134.175 | Flash Point | 96.1 °C |
| Transport Information | N/A | Appearance | colourless liquid |
| Safety | 23-24/25-39-26-36 | Risk Codes | 36-20-36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
 Xn, Xi
|
| Synonyms |
Carbitol;Carbitol SolventLow;Diethylene glycol ethyl ether;Diethylene glycol monoethyl ether;Diglycolmonoethyl ether;Dioxitol;Dowanol DE;Ektasolve DE;Ethanol, 2,2'-oxybis-,monoethyl ether;Ethyl Diglysolv;Ethyl carbitol;Ethyl digol;Ethyldiethyleneglycol;Ethylene diglycol monoethyl ether;NSC 408451;O-Ethyl digol;1-Hydroxy-3,6-dioxaoctane;Ethanol,2-(b-ethoxyethoxy)- (3CI);2-(2'-Ethoxyethoxy)ethanol;3,6-Dioxa-1-octanol;Poly-SolvDE;Shihozoru DG;2(2-Ethoxyethoxy)ethanol; |
Article Data | 12 |
2(2-Ethoxyethoxy)ethanol Synthetic route
- 197356-81-3
trimethylsilyl 2-[2-(2-ethoxyethoxy)ethoxy]-2,3,3,3-tetrafluoropropionate
A
- 111-90-0
ethoxyethoxyethanol
B
- 16654-46-9
Carbitol-trimethylsilylaether
| Conditions | Yield |
|---|---|
| With sodium hydroxide In tetrahydrofuran; water for 1h; Ambient temperature; | A n/a B n/a C 95% |
| Conditions | Yield |
|---|---|
| With tungsten(VI) oxide at 90 - 95℃; unter Druck; | |
| With sulfur dioxide at 75 - 80℃; |
| Conditions | Yield |
|---|---|
| With sulfuric acid at 100 - 130℃; im Autoklaven; | |
| With toluene-4-sulfonic acid at 100 - 130℃; | |
| With 2,3-Dimethylaniline at 100 - 130℃; | |
| With sulfuric acid at 80 - 100℃; | |
| With metal oxide at 100 - 130℃; |
| Conditions | Yield |
|---|---|
| (i) Na, (ii) /BRN= 1209224/; Multistep reaction; |
- 75-77-4
chloro-trimethyl-silane
- 197356-78-8
2-[2-(2-Ethoxy-ethoxy)-ethoxy]-2,3,3,3-tetrafluoro-propionic acid 2-(2-ethoxy-ethoxy)-ethyl ester
A
- 111-90-0
ethoxyethoxyethanol
B
- 16654-46-9
Carbitol-trimethylsilylaether
C
- 197356-81-3
trimethylsilyl 2-[2-(2-ethoxyethoxy)ethoxy]-2,3,3,3-tetrafluoropropionate
| Conditions | Yield |
|---|---|
| With sodium hydroxide; sodium hydride 1.) H2O, THF, 40 deg C, 3 h, 2.) Et2O, room temp., 3 h; Multistep reaction. Yields of byproduct given; | |
| With sodium hydroxide; sodium hydride 1.) H2O, THF, 40 deg C, 3 h, 2.) Et2O, room temp., 3 h; Yield given. Multistep reaction; |
- 197356-78-8
2-[2-(2-Ethoxy-ethoxy)-ethoxy]-2,3,3,3-tetrafluoro-propionic acid 2-(2-ethoxy-ethoxy)-ethyl ester
A
- 111-90-0
ethoxyethoxyethanol
| Conditions | Yield |
|---|---|
| With sodium hydroxide 1.) THF, H2O, 40 deg C, 3 h, 2.) 200 deg C; Yield given. Multistep reaction; |
| Conditions | Yield |
|---|---|
| at 90 - 95℃; under 7355.08 - 8826.09 Torr; |
| Conditions | Yield |
|---|---|
| With hydrogenchloride; water at 30 - 49.8℃; Kinetics; |
- 111-90-0
ethoxyethoxyethanol
- 98-59-9
p-toluenesulfonyl chloride
- 54176-27-1
2-(2-ethoxyethoxy)ethyl tosylate
| Conditions | Yield |
|---|---|
| With pyridine at 5℃; | 100% |
| With sodium hydroxide In tetrahydrofuran; water at 0 - 20℃; for 2h; Inert atmosphere; | 98% |
| With sodium hydroxide In tetrahydrofuran; water at 0 - 20℃; for 1.16667h; Inert atmosphere; | 95.8% |
- 111-90-0
ethoxyethoxyethanol
- 74325-03-4
methyl (E)-m-fluorocinnamate
| Conditions | Yield |
|---|---|
| Stage #1: ethoxyethoxyethanol With N-methyl-N-nitrosotoluene-p-sulfonamide; potassium hydroxide In diethyl ether; water at 65℃; Stage #2: methyl (E)-m-fluorocinnamate; palladium diacetate In diethyl ether; dichloromethane; water at 0 - 20℃; for 2.5h; | 100% |
| With potassium hydroxide; palladium diacetate In dichloromethane; water |
2(2-Ethoxyethoxy)ethanol Consensus Reports
Carbitol Cellosolve (CAS NO.111-90-0) is reported in EPA TSCA Inventory. Glycol ether compounds are on the Community Right-To-Know List.
2(2-Ethoxyethoxy)ethanol Specification
1. Introduction of 2-(2-Ethoxyethoxy)ethanol
2-(2-Ethoxyethoxy)ethanol, is an industrial solvent. It is a clear, colorless, hygroscopic liquid. Structurally it is an alcohol and an ether, a triethylene glycol with missing one hydroxyl group with formula CH3CH2OCH2CH2OCH2CH2OH. At direct contact it causes drying of skin by leaching fats, and is mildly irritating to the eyes. It is flammable.
2. Properties of 2-(2-Ethoxyethoxy)ethanol
MW: 134.17
EINECS: 203-919-7
Melting point: -80 °C
Index of Refraction: 1.419
Surface Tension: 31.6 dyne/cm
Density: 0.973 g/cm3
Flash Point: 96.1 °C
Enthalpy of Vaporization: 50.98 kJ/mol
Boiling Point: 202 °C at 760 mmHg
Vapour Pressure: 0.0733 mmHg at 25 °C
Water Solubility: Miscible
Sensitive: Hygroscopic
Merck: 14,1800
BRN: 1736441
Appearance Carbitol Cellosolve: colourless liquid
3. Toxicity of 2-(2-Ethoxyethoxy)ethanol
| 1. | skn-rbt 500 mg/24H MLD | JPETAB Journal of Pharmacology and Experimental Therapeutics. 82 (1944),377. | ||
| 2. | eye-rbt 500 mg MOD | UCDS** Union Carbide Data Sheet. (Industrial Medicine and Toxicology Dept., Union Carbide Corp., 270 Park Ave., New York, NY 10017) 11/22 ,1968. | ||
| 3. | eye-rbt 125 mg MLD | ADSYAF Archives of Dermatology and Syphilology. 45 (1942),553. | ||
| 4. | mmo-sat 986 mg/plate | BCFAAI Bollettino Chimico Farmaceutico. 125 (1986),401. | ||
| 5. | orl-rat LD50:5500 mg/kg | JIDHAN Journal of Industrial Hygiene. 21 (1939),173. | ||
| 6. | skn-rat LD50:6000 mg/kg | JIHTAB Journal of Industrial Hygiene and Toxicology. 29 (1947),190. |
LD50/LC50: RTECS:
CAS# 111-90-0: Dermal, guinea pig: LD50 = >32 gm/kg;
Draize test, rabbit, eye: 500 mg Moderate;
Draize test, rabbit, eye: 125 mg Mild;
Draize test, rabbit, skin: 500 mg/24H Mild;
Inhalation, rat: LC50 = >5240 mg/m3/4H;
Oral, mouse: LD50 = 6600 uL/kg;
Oral, mouse: LD50 = 7250 mg/kg;
Oral, rabbit: LD50 = 3620 mg/kg;
Oral, rat: LD50 = 5500 uL/kg;
Oral, rat: LD50 = 7500 mg/kg;
Skin, rabbit: LD50 = 4200 uL/kg;
Skin, rabbit: LD50 = 8.5 ml/kg/2H;
Skin, rat: LD50 = 6 mL/kg;
Carcinogenicity: 2(2-Ethoxyethoxy)ethanol - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
Other: See actual entry in RTECS for complete information. The toxicological properties have not been fully investigated.
4. Safety Information of 2-(2-Ethoxyethoxy)ethanol
Hazard Codes：
Xn,
Xi
Risk Statements：36-20-36/37/38
R36:Irritating to eyes.
R20:Harmful by inhalation.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements： 23-24/25-39-26-36
S23:Do not breathe vapour.
S24/25:Avoid contact with skin and eyes.
S39:Wear eye / face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany： 1
RTECS： KK8750000
HS Code： 29094400
Moderately toxic by ingestion, intravenous, intraperitoneal, and possibly other routes. Mildly toxic by skin contact. A skin and eye irritant. Experimental reproductive effects. Mutation data reported. Combustible when exposed to heat; can react with oxidizing materials. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes.
5. Use of 2-(2-Ethoxyethoxy)ethanol
2-(2-Ethoxyethoxy)ethanol can be used to make soaps, dyes, and other chemicals.
6. Other details of 2-(2-Ethoxyethoxy)ethanol
Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Incompatible materials, exposure to moist air or water.
Incompatibilities with Other Materials Strong oxidizing agents, strong acids, acid chlorides, anhydrides.
Hazardous Decomposition Products Carbon monoxide, carbon dioxide, peroxides.
Hazardous Polymerization Will not occur.
1、Fire Fighting Measures
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.
2、Handling and Storage
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage: Store in a cool, dry place. Store in a tightly closed container. Store under nitrogen.
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