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Name |
2,3-Difluoropyridine |
EINECS | N/A |
CAS No. | 1513-66-2 | Density | 1.264 g/cm3 |
PSA | 12.89000 | LogP | 1.35980 |
Solubility | N/A | Melting Point |
N/A |
Formula | C5H3F2N | Boiling Point | 116.476 °C at 760 mmHg |
Molecular Weight | 115.082 | Flash Point | 24.244 °C |
Transport Information | N/A | Appearance | N/A |
Safety | 26-36/37/39 | Risk Codes | 10-36/37/38 |
Molecular Structure | Hazard Symbols | T,F,Xi | |
Synonyms |
2,3-Difluorpyridin; |
Article Data | 10 |
5-chloro-2,3-difluoropyridine
2,3-difluoropyridine
Conditions | Yield |
---|---|
With ammonium formate; acetic acid; palladium on activated charcoal at 25℃; for 6h; | 75% |
palladium-carbon | |
palladium-carbon |
pyridine
A
perfluoro-N-ethylpyrrolidine
B
2,3-difluoropyridine
C
Pentafluoropyridine
D
N,N-Bis(trifluoromethyl)amine
Conditions | Yield |
---|---|
With caesium tetrafluorocobaltate(III) In gaseous matrix at 310℃; for 3.5h; Further byproducts given; | A 35.3% B 2.2% C 13.6% D 8.2% |
pyridine
A
2,3-difluoropyridine
B
4H,5H-heptafluoro-2-azahex-2(Z),4(E)-diene
C
5H-decafluoro-2-azahex-2(Z)-ene
D
undecafluoro-2-azahex-2(Z)-ene
Conditions | Yield |
---|---|
With potassium tetrafluorocobaltate In gaseous matrix at 215 - 225℃; 1.) 3.5-4 h; 2.) 2 h; Further byproducts given; |
Conditions | Yield |
---|---|
Stage #1: 2-chloro-3-aminopyridine With hexafluorophosphoric acid; sodium nitrite In water at 0℃; Stage #2: In xylene at 85℃; for 3h; Stage #3: With sodium hydrogencarbonate; triethylamine In water; xylene |
Conditions | Yield |
---|---|
With silver(II) fluoride In acetonitrile at 20℃; for 1h; Mechanism; | 55 %Spectr. |
2-chloro-3-fluoropyridine
2,3-difluoropyridine
Conditions | Yield |
---|---|
With tetramethylammonium fluoride In dimethyl sulfoxide at 80℃; for 24h; Inert atmosphere; Sealed tube; | 65 %Spectr. |
2,3-difluoropyridine
3-fluoro-2-hydrazinylpyridine
Conditions | Yield |
---|---|
With hydrazine hydrate at 120℃; for 1h; | 93% |
Conditions | Yield |
---|---|
Stage #1: 2,3-difluoropyridine With hydrazine hydrate In ethanol for 3h; Reflux; Stage #2: ethyl (ethoxymethylene)cyanoacetate In ethanol Reflux; | 91% |
Conditions | Yield |
---|---|
With potassium carbonate In dimethyl sulfoxide at 150℃; for 12h; Inert atmosphere; | 90% |
With potassium carbonate In dimethyl sulfoxide at 150℃; for 12h; Inert atmosphere; | 85% |
2,3-difluoropyridine
Conditions | Yield |
---|---|
With water; caesium carbonate In dimethyl sulfoxide at 110℃; for 12h; | 90% |
With water; caesium carbonate In dimethyl sulfoxide at 110℃; for 12h; | 90% |
The 2,3-Difluoropyridine, with the CAS registry number 1513-66-2, is also known as Pyridine, 2,3-difluoro-. And the molecular formula of this chemical is C5H3F2N. It belongs to the following product categories: Fluorin-contained pyridine series; Pyridine; Pyridines.
The physical properties of 2,3-Difluoropyridine are as following: (1)ACD/LogP: 1.30; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.299; (4)ACD/LogD (pH 7.4): 1.299; (5)ACD/BCF (pH 5.5): 5.717; (6)ACD/BCF (pH 7.4): 5.717; (7)ACD/KOC (pH 5.5): 121.23; (8)ACD/KOC (pH 7.4): 121.23; (9)#H bond acceptors: 1; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: 12.89 Å2; (13)Index of Refraction: 1.447; (14)Molar Refractivity: 24.332 cm3; (15)Molar Volume: 91.077 cm3; (16)Polarizability: 9.646×10-24cm3; (17)Surface Tension: 31.445 dyne/cm; (18)Density: 1.264 g/cm3; (19)Flash Point: 24.244 °C; (20)Enthalpy of Vaporization: 34.012 kJ/mol; (21)Boiling Point: 116.476 °C at 760 mmHg; (22)Vapour Pressure: 21.635 mmHg at 25°C.
You should be cautious while dealing with this chemical. It is a kind of flammable chemical which irritates eyes, respiratory system and skin. Therefore, you had better take the following instructions: Wear suitable protective clothing, gloves and eye/face protection, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
(1)SMILES: c1cc(c(nc1)F)F
(2)InChI: InChI=1/C5H3F2N/c6-4-2-1-3-8-5(4)7/h1-3H
(3)InChIKey: OGVLEPMNNPZAPS-UHFFFAOYAJ