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2,3-Difluoropyridine

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Name

2,3-Difluoropyridine

EINECS N/A
CAS No. 1513-66-2 Density 1.264 g/cm3
PSA 12.89000 LogP 1.35980
Solubility N/A Melting Point N/A
Formula C5H3F2N Boiling Point 116.476 °C at 760 mmHg
Molecular Weight 115.082 Flash Point 24.244 °C
Transport Information N/A Appearance N/A
Safety 26-36/37/39 Risk Codes 10-36/37/38
Molecular Structure Molecular Structure of 1513-66-2 (2,3-Difluoropyridine) Hazard Symbols ToxicT,FlammableF,IrritantXi
Synonyms

2,3-Difluorpyridin;

Article Data 10

2,3-Difluoropyridine Synthetic route

89402-43-7

5-chloro-2,3-difluoropyridine

1513-66-2

2,3-difluoropyridine

Conditions
ConditionsYield
With ammonium formate; acetic acid; palladium on activated charcoal at 25℃; for 6h;75%
palladium-carbon
palladium-carbon
110-86-1

pyridine

A

2344-10-7

perfluoro-N-ethylpyrrolidine

B

1513-66-2

2,3-difluoropyridine

C

700-16-3

Pentafluoropyridine

D

371-77-7

N,N-Bis(trifluoromethyl)amine

Conditions
ConditionsYield
With caesium tetrafluorocobaltate(III) In gaseous matrix at 310℃; for 3.5h; Further byproducts given;A 35.3%
B 2.2%
C 13.6%
D 8.2%
110-86-1

pyridine

A

1513-66-2

2,3-difluoropyridine

B

54471-09-9

4H,5H-heptafluoro-2-azahex-2(Z),4(E)-diene

C

54471-08-8

5H-decafluoro-2-azahex-2(Z)-ene

D

54471-05-5

undecafluoro-2-azahex-2(Z)-ene

Conditions
ConditionsYield
With potassium tetrafluorocobaltate In gaseous matrix at 215 - 225℃; 1.) 3.5-4 h; 2.) 2 h; Further byproducts given;
6298-19-7

2-chloro-3-aminopyridine

1513-66-2

2,3-difluoropyridine

Conditions
ConditionsYield
Stage #1: 2-chloro-3-aminopyridine With hexafluorophosphoric acid; sodium nitrite In water at 0℃;
Stage #2: In xylene at 85℃; for 3h;
Stage #3: With sodium hydrogencarbonate; triethylamine In water; xylene
372-47-4

3-Fluoropyridine

1513-66-2

2,3-difluoropyridine

Conditions
ConditionsYield
With silver(II) fluoride In acetonitrile at 20℃; for 1h; Mechanism;55 %Spectr.
17282-04-1

2-chloro-3-fluoropyridine

1513-66-2

2,3-difluoropyridine

Conditions
ConditionsYield
With tetramethylammonium fluoride In dimethyl sulfoxide at 80℃; for 24h; Inert atmosphere; Sealed tube;65 %Spectr.
1513-66-2

2,3-difluoropyridine

887266-57-1

3-fluoro-2-hydrazinylpyridine

Conditions
ConditionsYield
With hydrazine hydrate at 120℃; for 1h;93%
1513-66-2

2,3-difluoropyridine

94-05-3

ethyl (ethoxymethylene)cyanoacetate

ethyl 5-amino-1-(3-fluoropyridin-2-yl)-1H-pyrazole-4-carboxylate

Conditions
ConditionsYield
Stage #1: 2,3-difluoropyridine With hydrazine hydrate In ethanol for 3h; Reflux;
Stage #2: ethyl (ethoxymethylene)cyanoacetate In ethanol Reflux;
91%
1513-66-2

2,3-difluoropyridine

86-74-8

9H-carbazole

2,3-di(9H-carbazol-9-yl)pyridine

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 150℃; for 12h; Inert atmosphere;90%
With potassium carbonate In dimethyl sulfoxide at 150℃; for 12h; Inert atmosphere;85%
1513-66-2

2,3-difluoropyridine

3,3'-difluoro-2H-[1,2'-bipyridin]-2-one

Conditions
ConditionsYield
With water; caesium carbonate In dimethyl sulfoxide at 110℃; for 12h;90%
With water; caesium carbonate In dimethyl sulfoxide at 110℃; for 12h;90%

2,3-Difluoropyridine Specification

The 2,3-Difluoropyridine, with the CAS registry number 1513-66-2, is also known as Pyridine, 2,3-difluoro-. And the molecular formula of this chemical is C5H3F2N. It belongs to the following product categories: Fluorin-contained pyridine series; Pyridine; Pyridines.
 
The physical properties of 2,3-Difluoropyridine are as following: (1)ACD/LogP: 1.30; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.299; (4)ACD/LogD (pH 7.4): 1.299; (5)ACD/BCF (pH 5.5): 5.717; (6)ACD/BCF (pH 7.4): 5.717; (7)ACD/KOC (pH 5.5): 121.23; (8)ACD/KOC (pH 7.4): 121.23; (9)#H bond acceptors: 1; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: 12.89 Å2; (13)Index of Refraction: 1.447; (14)Molar Refractivity: 24.332 cm3; (15)Molar Volume: 91.077 cm3; (16)Polarizability: 9.646×10-24cm3; (17)Surface Tension: 31.445 dyne/cm; (18)Density: 1.264 g/cm3; (19)Flash Point: 24.244 °C; (20)Enthalpy of Vaporization: 34.012 kJ/mol; (21)Boiling Point: 116.476 °C at 760 mmHg; (22)Vapour Pressure: 21.635 mmHg at 25°C.

You should be cautious while dealing with this chemical. It is a kind of flammable chemical which irritates eyes, respiratory system and skin. Therefore, you had better take the following instructions: Wear suitable protective clothing, gloves and eye/face protection, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: c1cc(c(nc1)F)F
(2)InChI: InChI=1/C5H3F2N/c6-4-2-1-3-8-5(4)7/h1-3H
(3)InChIKey: OGVLEPMNNPZAPS-UHFFFAOYAJ

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