NTP 10th Report on Carcinogens. IARC Cancer Review: Animal Inadequate Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 20 ,1979,p. 349.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Limited Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 41 ,1986,p. 319.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Bioassay (feed); Clear Evidence: mouse, rat NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-155 ,1979. . Chlorophenol compounds are on the Community Right-To-Know List. Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

The IUPAC name of 2,4,6-Trichlorophenol is 2,4,6-trichlorophenol. With the CAS registry number 88-06-2, it is also named as Phenachlor. The product's categories are Phenoles and Thiophenoles; Alphabetic; TP-TZ; Organic Building Blocks; Oxygen Compounds; Phenols; Pesticides & Metabolites; Q-Z Alphabetic; Method 552 Analytical Standards; 500 Series Drinking Water Methods; Chloro EPA; TP - TZ; Alpha Sort; Analytical Standards; Aromatics Chemical Class; Chemical Class; Chloro Analytical Standards; Halogenated; Phenols Volatiles / Semivolatiles; T-ZAlphabetic. Besides, it is yellow to pinkish-orange needles or orange fluffy solid, which should be stored in sealed, ventilated and dry place at 0-6 °C. In addition, its molecular formula is C₆H₃Cl₃O and molecular weight is 197.45.

The other characteristics of this product can be summarized as: (1)EINECS: 201-795-9; (2)ACD/LogP: 3.58; (3)# of Rule of 5 Violations: 0; (4)ACD/LogD (pH 5.5): 3.54; (5)ACD/LogD (pH 7.4): 2.7; (6)ACD/BCF (pH 5.5): 284.15; (7)ACD/BCF (pH 7.4): 41.33; (8)ACD/KOC (pH 5.5): 1941.77; (9)ACD/KOC (pH 7.4): 282.45; (10)#H bond acceptors: 1; (11)#H bond donors: 1; (12)#Freely Rotating Bonds: 1; (13)Index of Refraction: 1.608; (14)Molar Refractivity: 42.81 cm³; (15)Molar Volume: 123.7 cm³; (16)Surface Tension: 50.5 dyne/cm; (17)Density: 1.596 g/cm³; (18)Flash Point: 95.9 °C; (19)Melting Point: 65-68 °C; (20)Water Solubility: 0.8 g/L; (21)Enthalpy of Vaporization: 50.27 kJ/mol; (22)Boiling Point: 246 °C at 760 mmHg; (23)Vapour Pressure: 0.0177 mmHg at 25 °C.

Preparation of 2,4,6-Trichlorophenol: this chemical can be prepared by Phenol. First, you can add Phenol into the reactor, then add Chlorine for 12 hours. The pre-reaction temperature is 60-65 °C, and then the temperature is 70-75 °C for 2-3 hours. After add Chlorine, please keep warm for 1 hour. At last, you can obtian this chemical by treating with Sodium sulfite.

Uses of 2,4,6-Trichlorophenol: this chemical is used as a fungicide, herbicide, insecticide, antiseptic, defoliant, and glue preservative. What's more, it can react with Benzenesulfonyl chloride to get Benzenesulfonic acid-(2,4,6-trichloro-phenyl ester).



This reaction needs diluted KOH-solution.

When you are using this chemical, please be cautious about it as the following: it is highly flammable. Please keep away from sources of ignition. It is also harmful if swallowed and irritating to eyes, skin. Moreover, it is toxic by inhalation, in contact with skin and if swallowed, and danger of very serious irreversible effects. Limited evidence of a carcinogenic effect. You should wear suitable protective clothing and gloves.Additionally, it is very toxic and harmful to aquatic organisms that may cause long-term adverse effects in the aquatic environment. This material and its container must be disposed of as hazardous waste. Please avoid release to the environment. Refer to special instructions / safety data sheets. Furthermore, in case of accident or if you feel unwell, please seek medical advice immediately (show the label whenever possible.)

People can use the following data to convert to the molecule structure.
(1)Canonical SMILES: C1=C(C=C(C(=C1Cl)O)Cl)Cl
(2)InChI: InChI=1S/C6H3Cl3O/c7-3-1-4(8)6(10)5(9)2-3/h1-2,10H
(3)InChIKey: LINPIYWFGCPVIE-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	oral	1gm/kg (1000mg/kg)		Farm Chemicals Handbook. Vol. -, Pg. C310, 1991.
mammal (species unspecified)	LD50	oral	454mg/kg (454mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(10), Pg. 16, 1980.
mammal (species unspecified)	LD50	skin	700mg/kg (700mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(10), Pg. 16, 1980.
rat	LD50	intraperitoneal	276mg/kg (276mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	British Journal of Pharmacology and Chemotherapy. Vol. 13, Pg. 20, 1958.
rat	LD50	oral	820mg/kg (820mg/kg)		Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 1176, 1966.