Reported in EPA TSCA Inventory.

1. Introduction of 2,6-Diisopropylaniline
2,6-Diisopropylaniline, with CAS number of 24544-04-5, can be called 2,6-Bis(1-methylethyl)aniline; 2,6-Bis(1-methylethyl)benzenamine; 2,6-Diisopropylphenylamine ; N-(2,6-Diisopropylphenyl)amine. 2,6-Diisopropylaniline is stable under normal temperatures and pressures, but incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides, chloroformates. The colorless to pale orange liquid slightly soluble in water and the solubility is less than 0.20g/L.

2. Properties of 2,6-Diisopropylaniline
H bond acceptors: 1
H bond donors: 2
Freely Rotating Bonds: 3
Polar Surface Area: 26.02 Å²
Index of Refraction: 1.525
Molar Refractivity: 58.85 cm³
Molar Volume: 191.8 cm³
Surface Tension: 33.9 dyne/cm
Enthalpy of Vaporization: 49.49 kJ/mol
Vapour Pressure: 0.0147 mmHg at 25°C
Density: 1.2 g/cm³
Melting Point: -45 °C(lit.)
Flash Point: 208.2 °C
Boiling Point: 420.7 °C at 760 mmHg
Water solubility:  <0.20 g/L
Product Categories: Amines; C11 to C38; Nitrogen Compounds; Aniline Derivatives; o-alkylated Anilines

3. Toxicity of 2,6-Diisopropylaniline

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rat	LD50	oral	3204mg/kg (3204mg/kg)	LIVER: OTHER CHANGES BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE BLOOD: CHANGES IN SPLEEN	Fundamental and Applied Toxicology. Vol. 3, Pg. 285, 1983.

4. Safety Information of 2,6-Diisopropylaniline
Moderately toxic by ingestion. When heated to decomposition it emits toxic vapors of NO_x.
Hazard Codes: Xi
Risk Statements:
R36/37/38: Irritating to eyes, respiratory system and skin.
R52/53: Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic
Safety Statements:
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S61 Avoid release to the environment. Refer to special instructions / safety data sheets.
S37/39: Wear suitable gloves and eye/face protection.
WGK Germany: 2
RTECS: BX4025000
HS Code: 29214980

5. Use of 2,6-Diisopropylaniline
2,6-Diisopropylaniline is an important intermediates for the manufacture of carbodiimides stabilizers, RIM-PUR, synthetic resins, pesticides, antioxidants, pharmaceuticals and other products and it is a key intermediate for synthesis of new insecticides Diafenthiuron on pesticides synthetic.

6. Preparation of 2,6-Diisopropylaniline
2,6 diisopropylaniline was made by the high pressure liquid alkylation of aniline and propene under the aluminum catalysis. The conversion of aniline and the selectivity of 2,6 diisopropylaniline was respectively more than 80% and 50% under the conditions of the molar ratio of aniline to propene being 1:2 at 280～290 °C for 4～5 hrs.