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Name	2-Amino-1-(2,5-dimethoxyphenyl)ethanol	EINECS	N/A
CAS No.	3600-87-1	Density	g/cm³
PSA	64.71000	LogP	1.39620
Solubility	N/A	Melting Point	146-150°C dec.
Formula	C10H15 N O3	Boiling Point	364.3°Cat760mmHg
Molecular Weight	197.234	Flash Point	174.1°C
Transport Information	N/A	Appearance	N/A
Safety		Risk Codes	N/A
Molecular Structure		Hazard Symbols	N/A
Synonyms	Benzylalcohol, a-(aminomethyl)-2,5-dimethoxy-(7CI,8CI); 1-(2,5-Dimethoxyphenyl)-2-aminoethanol; Deglymidodrine;Desglymidodrine; ST 1059	Article Data	7

2-Amino-1-(2,5-dimethoxyphenyl)ethanol Synthetic route

: 14438-63-2
1-(2,5-dimethoxyphenyl)-2-nitroethanol

: 3600-87-1
desglymidodrine

Conditions

Conditions	Yield
With sodium tetrahydroborate In ethanol at -10℃; for 2h; Solvent; Reagent/catalyst;	83%

: 141367-35-3
2-(2,5-dimethoxyphenyl)-2-trimethylsilyloxyacetonitrile

: 3600-87-1
desglymidodrine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether for 1h; Heating;	54%

: 83436-65-1, 141303-39-1
1,2-epoxy-1-(2,5-dimethoxyphenyl)ethane

: 3600-87-1
desglymidodrine

Conditions

Conditions	Yield
With ammonia In ethanol for 120h; Ambient temperature;

2-amino-1-<2.5-dimethoxy-phenyl>-ethanone-(1)-hydrochloride: 2-amino-1-<2.5-dimethoxy-phenyl>-ethanone-(1)-hydrochloride

: 3600-87-1
desglymidodrine

Conditions

Conditions	Yield
With ethanol; platinum Hydrogenation;
With water; platinum Hydrogenation;

5-<2.5-dimethoxy-phenyl>-oxazolidinone-(2): 5-<2.5-dimethoxy-phenyl>-oxazolidinone-(2)

: 3600-87-1
desglymidodrine

Conditions

Conditions	Yield
With hydrogenchloride

: 2-amino-1-(2,5-dimethoxyphenyl)ethanone hydrochloride

: 3600-87-1
desglymidodrine

Conditions

Conditions	Yield
With sodium tetrahydroborate In methanol at 0℃; for 0.5h;

: 1204-21-3
2-bromo-2',5'-dimethoxyacetophenone

: 3600-87-1
desglymidodrine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: NaBH4 / dioxane; H2O / 1 h / Ambient temperature 2: KOH / diethyl ether; H2O / 0.5 h / Heating 3: NH3 / ethanol / 120 h / Ambient temperature View Scheme

: 2-Bromo-1-(2,5-dimethoxy-phenyl)-ethanol

: 3600-87-1
desglymidodrine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: KOH / diethyl ether; H2O / 0.5 h / Heating 2: NH3 / ethanol / 120 h / Ambient temperature View Scheme

: 93-02-7
2,5-dimethoxybenzaldehyde

alkaline permanganate: alkaline permanganate

: 3600-87-1
desglymidodrine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 90 percent / zinc iodide / 1 h / Ambient temperature 2: 54 percent / lithium aluminum hydride / diethyl ether / 1 h / Heating View Scheme

: 56979-58-9
2-(2,5-dimethoxyphenyl)-2-hydroxyacetonitrile

: 3600-87-1
desglymidodrine

Conditions

Conditions	Yield
With hydrogenchloride; borane In tetrahydrofuran	1.5 g (52%)

2-Amino-1-(2,5-dimethoxyphenyl)ethanol Chemical Properties

Molecular Structure of 2-Amino-1-(2,5-dimethoxyphenyl)ethanol (CAS NO.3600-87-1):

IUPAC Name: 2-Amino-1-(2,5-dimethoxyphenyl)ethanol
Molecular Formula: C₁₀H₁₅NO₃
Molecular Weight: 197.23
XLogP3-AA: 0.1
H-Bond Donor: 2
H-Bond Acceptor: 4
Melting Point: 146-150 °C
Index of Refraction: 1.542
Molar Refractivity: 54.23 cm³
Molar Volume: 172.1 cm³
Surface Tension: 43.2 dyne/cm
Density: 1.145 g/cm³
Flash Point: 174.1 °C
Enthalpy of Vaporization: 64.41 kJ/mol
Boiling Point: 364.3 °C at 760 mmHg
Vapour Pressure: 6.02E-06 mmHg at 25 °C
Appearance: White Powder
Product Categories: Metabolites
Canonical SMILES: COC1=CC(=C(C=C1)OC)C(CN)O
InChIKey: VFRCNXKYZVQYLX-UHFFFAOYSA-N
InChI: InChI=1S/C10H15NO3/c1-13-7-3-4-10(14-2)8(5-7)9(12)6-11/h3-5,9,12H,6,11H2,1-2H3

2-Amino-1-(2,5-dimethoxyphenyl)ethanol Uses

2-Amino-1-(2,5-dimethoxyphenyl)ethanol (CAS NO.3600-87-1) is used as a metabolite of Midodrine. It induces alpha-adrenergic receptor stimulation of both arterial and venous systems without direct central nervous systme of cardiac effects.

2-Amino-1-(2,5-dimethoxyphenyl)ethanol Specification

2-Amino-1-(2,5-dimethoxyphenyl)ethanol (CAS NO.3600-87-1), its Synonyms are Benzyl alcohol, alpha-(aminomethyl)-2,5-dimethoxy- ; alpha-(Aminomethyl)-2,5-dimethoxybenzenemethanol ; 1-(2',5'-Dimethoxyphenyl)aminoethanol ; ST-1059 ; Benzylalcohol, a-(aminomethyl)-2,5-dimethoxy-(7CI,8CI) ; 1-(2,5-Dimethoxyphenyl)-2-aminoethanol ; Deglymidodrine ; Desglymidodrine ; 2,5-Dimethoxyphenyl-2-hydroxyethylamine .

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