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Cas Database |
| Name |
2-Amino-5-chlorobenzophenone |
EINECS | 211-949-7 |
| CAS No. | 719-59-5 | Density | 1.274 g/cm3 |
| PSA | 43.09000 | LogP | 3.73440 |
| Solubility | insoluble | Melting Point |
96-98 °C(lit.) |
| Formula | C13H10ClNO | Boiling Point | 424.3 °C at 760 mmHg |
| Molecular Weight | 231.681 | Flash Point | 210.4 °C |
| Transport Information | N/A | Appearance | yellow powder |
| Safety | 26-36 | Risk Codes | 36/37/38-22-20/21/22 |
| Molecular Structure |
|
Hazard Symbols |
 Xn，  Xi
|
| Synonyms |
(2-amino-5-chlorophenyl)(phenyl)methanone;Aminoketone;Benzophenone, 2-amino-5-chloro- (8CI);5-Chloro-2-aminobenzophenone;Benzophenone, 2-amino-5-chloro-;(2-amino-5-chloro-phenyl)-phenyl-methanone;(2-Amino-5-chlorophenyl)phenylmethanone;Methanone, (2-amino-5-chlorophenyl)phenyl-;2-Benzoyl-4-chloroaniline;2-Amino-5-chlorobenzylphenone; |
Article Data | 107 |
2-Amino-5-chlorobenzophenone Synthetic route
| Conditions | Yield |
|---|---|
| With trimethylsilyl iodide; water In acetonitrile at 20℃; for 0.2h; | 98% |
| Stage #1: 5-chloro-3-phenylanthranil With iron In ethanol for 0.5h; Reflux; Stage #2: With sulfuric acid In ethanol for 1h; Reflux; | 95.1% |
| With aluminium trichloride; zinc In tetrahydrofuran for 6h; Ambient temperature; | 92% |
| Conditions | Yield |
|---|---|
| With 5,5'-dimethyl-2,2'-bipyridine; methanesulfonic acid; palladium(II) trifluoroacetate; water In 2-methyltetrahydrofuran at 80℃; for 36h; Schlenk technique; | 96% |
| With [2,2]bipyridinyl; methanesulfonic acid; palladium(II) trifluoroacetate In tetrahydrofuran; water at 80℃; for 36h; |
- 719-59-5
2-Amino-5-chlorobenzophenone
| Conditions | Yield |
|---|---|
| With triethylene diamine nickel thiosulfate; water In chloroform at 20℃; for 0.166667h; Hydrolysis; | 92% |
- 5922-60-1
2-amino-5-chlorobenzonitrile
- 873-55-2
sodium benzenesulfonate
- 719-59-5
2-Amino-5-chlorobenzophenone
| Conditions | Yield |
|---|---|
| With p-nitrobenzenesulfonic acid; palladium diacetate In tetrahydrofuran; water at 80℃; for 48h; Inert atmosphere; Schlenk technique; | 92% |
| Conditions | Yield |
|---|---|
| Stage #1: benzamide; 4-chloro-aniline With tin(ll) chloride at 123 - 250℃; for 4h; Stage #2: With potassium chloride at 95 - 130℃; for 4h; Stage #3: With phosphoric acid for 23h; Concentration; Temperature; Reflux; | 91% |
- 105448-12-2
7-Chlor-2-methylthio-5-phenyl-3H-1,3,4-benzotriazepin
A
- 74-93-1
methylthiol
B
- 719-59-5
2-Amino-5-chlorobenzophenone
| Conditions | Yield |
|---|---|
| With hydrogenchloride for 10h; | A n/a B 83.4% |
| Conditions | Yield |
|---|---|
| With gallium(III) trichloride; boron trichloride In chlorobenzene at 100℃; for 20h; | 81% |
| With gallium(III) trichloride; boron trichloride 1.) CH2Cl2, 1,1,2,2-tetrachloroethane, 0 deg C, 2.) 1,1,2,2-tetrachloroethane, 100 deg C, 5 h; Yield given. Multistep reaction; |
- 719-64-2
5-chloro-3-phenylanthranil
- 98-80-6
phenylboronic acid
A
- 719-59-5
2-Amino-5-chlorobenzophenone
B
- 108694-41-3
(5-chloro-2-(phenylamino)phenyl)(phenyl)methanone
| Conditions | Yield |
|---|---|
| With potassium carbonate; copper dichloride In dimethyl sulfoxide at 100℃; for 6h; Reagent/catalyst; Solvent; Sealed tube; | A 17% B 81% |
| Conditions | Yield |
|---|---|
| With antimony(III) oxide In dichloromethane at 15℃; for 2h; Temperature; | 78% |
| Stage #1: 4-chloro-aniline; benzoyl chloride With antimony(III) trioxide In dichloromethane at 15℃; for 2h; Friedel-Crafts Acylation; Stage #2: With nitric acid In dichloromethane at 10 - 45℃; for 11.5h; Temperature; | 77% |
| With dysprosium((III) oxide In tetrachloromethane at 15℃; for 2h; Temperature; | 76% |
- 86230-82-2
7-chloro-9-phenyl-1,2-dihydrooxazolo<2,3-b>-1,3,4-benzotriazepine
- 719-59-5
2-Amino-5-chlorobenzophenone
| Conditions | Yield |
|---|---|
| With sulfuric acid In ethanol at 40℃; for 1.16667h; | 75% |
2-Amino-5-chlorobenzophenone Chemical Properties
IUPAC Name: (2-amino-5-chlorophenyl)-phenylmethanone
Empirical Formula: C13H10ClNO
Molecular Weight: 231.6776g/mol
EINECS: 211-949-7
Structure of 2-Amino-5-chlorobenzophenone (CAS NO.719-59-5):
Index of Refraction: 1.636
Molar Refractivity: 65.17 cm3
Molar Volume: 181.7 cm3
Polarizability: 25.83×10-24cm3
Surface Tension: 52.2 dyne/cm
Density: 1.274 g/cm3
Flash Point: 210.4 °C
Enthalpy of Vaporization: 67.87 kJ/mol
Melting Point: 96-98 °C(lit.)
Boiling Point: 424.3 °C at 760 mmHg
Vapour Pressure: 2.09E-07 mmHg at 25°C
Stability: Stable. Incompatible with strong oxidizing agents.
Product Categories: Benzene derivatives;FINE Chemical & INTERMEDIATES;Aromatic Benzophenones & Derivatives (substituted);ketone;Diazepam
Canonical SMILES: C1=CC=C(C=C1)C(=O)C2=C(C=CC(=C2)Cl)N
InChI: InChI=1S/C13H10ClNO/c14-10-6-7-12(15)11(8-10)13(16)9-4-2-1-3-5-9/h1-8H,15H2
InChIKey: ZUWXHHBROGLWNH-UHFFFAOYSA-N
2-Amino-5-chlorobenzophenone Toxicity Data With Reference
| 1. | ipr-mus LD50:681 mg/kg | IJSIDW Indian Journal of Pharmaceutical Sciences. (Indian Journal of Pharmaceutical Sciences, Kalina, Santa Cruz 44 (1982),1. |
2-Amino-5-chlorobenzophenone Consensus Reports
Reported in EPA TSCA Inventory.
2-Amino-5-chlorobenzophenone Safety Profile
Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic vapors of NOx and Cl−.
Hazard Codes: 
Xi,Xn
The Risk Statements information of 2-AMINO-5-CHLOROBENZOPHENONE :
22: Harmful if swallowed
20/21/22: Harmful by inhalation, in contact with skin and if swallowed
36/37/38: Irritating to eyes, respiratory system and skin
The Safety Statements information of 2-AMINO-5-CHLOROBENZOPHENONE :
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
WGK Germany: 3
RTECS: PC4933500
HS Code: 29223900
2-Amino-5-chlorobenzophenone Specification
2-Amino-5-chlorobenzophenone , its cas register number is 719-59-5. It also can be called (2-Amino-5-chlorophenyl)phenylmethanone ; 2-Benzoyl-4-chloroaniline ; 3-14-00-00214 (Beilstein Handbook Reference) ; 5-Chloro-2-aminobenzophenone . 2-Amino-5-chlorobenzophenone (CAS NO.719-59-5) is a yellow powder.
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