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Cas Database |
| Name |
2-Chloro-5-nitroaniline |
EINECS | 228-498-7 |
| CAS No. | 6283-25-6 | Density | 1.494 g/cm3 |
| PSA | 71.84000 | LogP | 2.93480 |
| Solubility | N/A | Melting Point |
118-120 °C(lit.) |
| Formula | C6H5ClN2O2 | Boiling Point | 314.6 °C at 760 mmHg |
| Molecular Weight | 172.571 | Flash Point | 144.1 °C |
| Transport Information | UN 2237 6.1/PG 3 | Appearance | yellow powder |
| Safety | 28-36/37-45-61-28A-60-13 | Risk Codes | 26/27/28-33-51/53-50/53 |
| Molecular Structure |
|
Hazard Symbols |
 T+,  N
|
| Synonyms |
Aniline,2-chloro-5-nitro- (7CI,8CI);1-Amino-2-chloro-5-nitrobenzene;2-Chloro-5-nitrobenzenamine;2-Chloro-5-nitrophenylamine;5-Nitro-2-chloroaniline;6-Chloro-3-nitroaniline;Benzenamine,2-chloro-5-nitro-; |
Article Data | 27 |
2-Chloro-5-nitroaniline Synthetic route
| Conditions | Yield |
|---|---|
| With sulfuric acid; uronium nitrate at 0 - 10℃; for 1h; | 76% |
| With sulfuric acid; guanidine nitrate at 0 - 5℃; for 1h; | 76% |
| With sulfuric acid; potassium nitrate | |
| With sulfuric acid; nitric acid | |
| With sulfuric acid durch Nitrierung; |
- 136833-46-0
2-nitro-4-amino-5-chlorobenzoic acid
- 6283-25-6
H2NC6H3(Cl)NO2
| Conditions | Yield |
|---|---|
| With hydrogenchloride Heating; | 70% |
| Conditions | Yield |
|---|---|
| With hydrogen; iron; acetic acid; palladium dichloride In ethanol at 20 - 25℃; under 258.6 - 2327.2 Torr; | A n/a B 61% |
| With benzophenone; triethylamine In isopropyl alcohol for 2h; Product distribution; Irradiation; | A 18% B n/a |
| With hydrogenchloride; ethanol; tin(ll) chloride |
- 10403-47-1
2-bromo 5-nitroaniline
- 6283-25-6
H2NC6H3(Cl)NO2
| Conditions | Yield |
|---|---|
| With trans-bis(glycinato)copper(II) monohydrate; tetramethlyammonium chloride In ethanol at 100℃; for 30h; Finkelstein Reaction; Schlenk technique; Inert atmosphere; | 55% |
- 16588-15-1
2-chloro-5-nitro-benzamide
- 6283-25-6
H2NC6H3(Cl)NO2
| Conditions | Yield |
|---|---|
| With sodium hydroxide; bromine |
- 22698-95-9
N-(o-chlorophenyl)-phthalimide
- 6283-25-6
H2NC6H3(Cl)NO2
| Conditions | Yield |
|---|---|
| With sulfuric acid; nitric acid Erhitzen des Reaktionsprodukts mit wss.Natronlauge; |
| Conditions | Yield |
|---|---|
| With sulfuric acid; nitric acid man waescht den Niederschlag mit Wasser aus und destilliert mit Natronlauge; die ueberdestillierten Basen trennt man durch Krystallisation aus Ligroin; |
| Conditions | Yield |
|---|---|
| Electrolysis; |
2-Chloro-5-nitroaniline Chemical Properties
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IUPAC Name: 2-Chloro-5-nitroaniline
Molecular Formula: C6H5ClN2O2
Molecular Weight: 172.57 g/mol
SMILES: c1(cc(c(Cl)cc1)N)[N+](=O)[O-]
InChI: InChI=1/C6H5ClN2O2/c7-5-2-1-4(9(10)11)3-6(5)8/h1-3H,8H2
EINECS: 228-498-7
Product Categories: Intermediates of Dyes and Pigments; Anilines, Aromatic Amines and Nitro Compounds
Melting Point: 118-120 °C(lit.)
Index of Refraction: 1.646
Molar Refractivity: 41.92 cm3
Molar Volume: 115.5 cm3
Polarizability: 16.62×10-24 cm3
Surface Tension: 62.2 dyne/cm
Density: 1.494 g/cm3
Flash Point: 144.1 °C
Enthalpy of Vaporization: 55.58 kJ/mol
Boiling Point: 314.6 °C at 760 mmHg
Vapour Pressure of 2-Chloro-5-nitroaniline (CAS NO.6283-25-6): 0.00046 mmHg at 25 °C
2-Chloro-5-nitroaniline Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 800mg/kg (800mg/kg) | Office of Toxic Substances Report. Vol. OTS, | |
| mouse | LD50 | intravenous | 180mg/kg (180mg/kg) | U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03227, | |
| mouse | LD50 | oral | 1600mg/kg (1600mg/kg) | Office of Toxic Substances Report. Vol. OTS, | |
| rat | LD50 | intraperitoneal | 400mg/kg (400mg/kg) | Office of Toxic Substances Report. Vol. OTS, | |
| rat | LD50 | oral | 2015mg/kg (2015mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: MUSCLE WEAKNESS | Office of Toxic Substances Report. Vol. OTS, |
2-Chloro-5-nitroaniline Consensus Reports
Reported in EPA TSCA Inventory.
2-Chloro-5-nitroaniline Safety Profile
A poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. When heated to decomposition it emits toxic vapors of NOx and Cl−.
Hazard Codes: 
T+, 
N
Risk Statements: 26/27/28-33-51/53-50/53
R26/27/28:Very toxic by inhalation, in contact with skin and if swallowed.
R33:Danger of cumulative effects.
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
R50/53:Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements: 28-36/37-45-61-28A-60-13
S28:After contact with skin, wash immediately with plenty of soap-suds.
S36/37:Wear suitable protective clothing and gloves.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.
S60:This material and its container must be disposed of as hazardous waste.
S13:Keep away from food, drink and animal foodstuffs.
RIDADR: UN 2237 6.1/PG 3
WGK Germany: 3
RTECS: BX1500000
HazardClass: 6.1
PackingGroup of 2-Chloro-5-nitroaniline (CAS NO.6283-25-6): III
2-Chloro-5-nitroaniline Specification
2-Chloro-5-nitroaniline (CAS NO.6283-25-6), its Synonyms are 2-Chloro-5-nitrobenzenamine ; 6-Chloro-3-nitroaniline ; Aniline, 2-chloro-5-nitro- ; Aniline, 6-chloro-3-nitro- ; Benzenamine, 2-chloro-5-nitro- . It is yellow powder.
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