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2-Dimethylaminoisopropyl chloride hydrochloride
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Name

2-Dimethylaminoisopropyl chloride hydrochloride

 EINECS 224-971-7
CAS No. 4584-49-0 Density N/A
PSA 3.24000 LogP 1.97730
Solubility 2000 g/L (20 °C) in water Melting Point 187-190 °C(lit.)
Formula C5H13Cl2N Boiling Point 81.1 °C at 760 mmHg
Molecular Weight 158.071 Flash Point 2.9 °C
Transport Information UN 2811 Appearance Colourless to pale beige crystalline powder
Safety 26-36 Risk Codes 22-36/37/38
Molecular Structure Molecular Structure of 4584-49-0 (2-Dimethylaminoisopropyl chloride hydrochloride) Hazard Symbols HarmfulXn, IrritantXi
Synonyms

1-Propanamine,2-chloro-N,N-dimethyl-, hydrochloride (9CI);Propylamine,2-chloro-N,N-dimethyl-, hydrochloride (7CI,8CI);(2-Chloropropyl)dimethylaminehydrochloride;1-(Dimethylamino)-2-chloropropane hydrochloride;1-Dimethylamino-2-propylchloride hydrochloride;1-Dimethylaminopropan-2-yl chloride hydrochloride;1-Methyl-2-dimethylaminoethyl chloride hydrochloride;2-(Dimethylamino)isopropyl chloride hydrochloride;2-Chloro-N,N-dimethyl-1-propanamine hydrochloride;2-Chloro-N',N'-dimethylaminopropane hydrochloride;Dimethylaminoisopropyl chloride hydrochloride;N,N-Dimethyl-2-chloropropylaminehydrochloride;NSC 53532;NSC 5367;

Article Data 4

2-Dimethylaminoisopropyl chloride hydrochloride Synthetic route

108-16-7

1-methyl-2-N,N-dimethylaminoethanol

4584-49-0

(2-chloropropyl)dimethylamine hydrochloride

Conditions
ConditionsYield
With thionyl chloride In chloroform at 0 - 20℃; for 1h; Reflux;95%
With thionyl chloride In chloroform95%
With thionyl chloride In chloroform Reflux; Cooling with ice;

1-dimethylamino-2-propanol hydrochloride

4584-49-0

(2-chloropropyl)dimethylamine hydrochloride

Conditions
ConditionsYield
With thionyl chloride at 60℃; for 24h;
4584-49-0

(2-chloropropyl)dimethylamine hydrochloride

550372-56-0

6,7-methylenedioxyquinoline-4-carboxylic acid N-(2-iodo-4,5-dimethoxyphenyl)amide

6,7-methylenedioxyquinoline-4-carboxylic acid N-[2-(N,N-dimethylamino)isopropyl]-N-(2-iodo-4,5-dimethoxyphenyl)amide

Conditions
ConditionsYield
With sodium hydride; sodium iodide In N,N-dimethyl-formamide at 65℃; for 3h;89%
4584-49-0

(2-chloropropyl)dimethylamine hydrochloride

108-14-5

2-chloro-1-dimethylaminopropane

Conditions
ConditionsYield
With sodium hydroxide In water82%

7-methoxy-3-phenyl-4{2-[4-hydroxy-phenyl]-vinyl}chromen-2-one

4584-49-0

(2-chloropropyl)dimethylamine hydrochloride

4{2-[4-(2-dimethylamino-1-methyl-ethoxy)phenyl]-vinyl}-7-methoxy-3-phenylchromen-2-one

Conditions
ConditionsYield
With potassium carbonate In acetone for 6h; Reflux;80%
4584-49-0

(2-chloropropyl)dimethylamine hydrochloride

2-azido-3-(N,N-dimethylamino)propane

Conditions
ConditionsYield
With sodium azide In water at 80℃;80%
1469863-78-2

1-(3-(4-hydroxyphenyl)-7-methoxy-3,3a,4,5-tetrahydro-2H-benzo[g]indazol-2-yl)ethanone

4584-49-0

(2-chloropropyl)dimethylamine hydrochloride

1469863-82-8

C25H31N3O3

Conditions
ConditionsYield
With potassium carbonate In chloroform; acetone at 80℃;75%
1469863-67-9

8-methoxy-4-(4-hydroxyphenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine

4584-49-0

(2-chloropropyl)dimethylamine hydrochloride

1469863-71-5

4-(4-(1-(dimethylamino)propan-2-yloxy)phenyl)-5,6-dihydro-8-methoxybenzo[h]quinazolin-2-amine

Conditions
ConditionsYield
With potassium carbonate In chloroform; acetone at 80℃;75%
With potassium carbonate In chloroform; acetone at 80℃;75%
4584-49-0

(2-chloropropyl)dimethylamine hydrochloride

160985-00-2

1-(5-cyano-2-mercaptobenzenesulphonyl)-2-imidazolidinone

4-(2-Dimethylamino-1-methyl-ethylsulfanyl)-3-(2-oxo-imidazolidine-1-sulfonyl)-benzonitrile

Conditions
ConditionsYield
With sodium isopropylate In isopropyl alcohol for 16h; Heating;65%
571-72-2

4'-Hydroxywogonin

4584-49-0

(2-chloropropyl)dimethylamine hydrochloride

5-(1-(dimethylamino)propan-2-yloxy)-3-hydroxy-7,8-dimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one

Conditions
ConditionsYield
With potassium carbonate In acetone at 80℃;63%

2-Dimethylaminoisopropyl chloride hydrochloride Chemical Properties

IUPAC Name: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride
Synonyms of 1-Propanamine,2-chloro-N,N-dimethyl-, hydrochloride (1:1) (CAS NO.4584-49-0): 2-Chloropropyl)dimethylamine monohydrochloride ; 1-(Dimethylamino)-2-chloropropane hydrochloride ; 1-Methyl-2-dimethylaminoethyl chloride hydrochloride ; 2-(Dimethylamino)-1-methylethyl chloride hydrochloride ; 2-(Dimethylamino)isopropyl chloride hydrochloride ; 2-Chloro-N',N'-dimethylaminopropane hydrochloride ; 2-Chloro-N,N-dimethyl-1-propanamine hydrochloride ; 2-Chloropropyl-dimethylamine hydrochloride ; AI3-26684 ; EINECS 224-971-7 ; N,N-Dimethyl-2-chloropropylamine hydrochloride ; NSC 53532 ; NSC 5367 ; Propane, 1-(N,N-dimethylamino)-2-chloro-, hydrochloride
CAS NO: 4584-49-0
Classification Code: Drug / Therapeutic Agent
Molecular Formula of 1-Propanamine,2-chloro-N,N-dimethyl-, hydrochloride (1:1) (CAS NO.4584-49-0): C5H13Cl2N
Molecular Weight: 158.0694
Molecular Structure:

Melting Point: 187-190 °C 
Polar Surface Area: 3.24 Å2
Flash Point of 1-Propanamine,2-chloro-N,N-dimethyl-, hydrochloride (1:1) (CAS NO.4584-49-0): 2.9 °C
Enthalpy of Vaporization: 32.18 kJ/mol
Boiling Point: 81.1 °C at 760 mmHg
Vapour Pressure: 83 mmHg at 25°C

2-Dimethylaminoisopropyl chloride hydrochloride Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 subcutaneous 200mg/kg (200mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Journal of Pharmacology and Experimental Therapeutics. Vol. 98, Pg. 121, 1950.

2-Dimethylaminoisopropyl chloride hydrochloride Safety Profile

Hazard Codes: HarmfulXn,IrritantXi
Risk Statements: 22-36/37/38 
R22: Harmful if swallowed. 
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36: Wear suitable protective clothing.
RIDADR: 2811
WGK Germany: 3
RTECS: TY1225000
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 29211980

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