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Cas Database

Name	2-Hydroxy-4-methoxybenzaldehyde	EINECS	211-604-0
CAS No.	673-22-3	Density	1.231 g/cm³
PSA	46.53000	LogP	1.21330
Solubility	Solubility in methanol is almost transparent. Insoluble in water.	Melting Point	41-43 °C(lit.)
Formula	C₈H₈O₃	Boiling Point	271.5 °C at 760 mmHg
Molecular Weight	152.15	Flash Point	112.1 °C
Transport Information	N/A	Appearance	creamy white to beige or light brown cryst. powder
Safety	26-36-24/25	Risk Codes	36/37/38
Molecular Structure		Hazard Symbols	Xi
Synonyms	p-Anisaldehyde,2-hydroxy- (6CI,7CI,8CI);2-Formyl-5-methoxyphenol;2-Hydroxy-p-anisaldehyde;4-Methoxy-6-hydroxybenzaldehyde;4-Methoxysalicylaldehyde;NSC 155334;o-Hydroxy-p-methoxybenzaldehyde;	Article Data	100

2-Hydroxy-4-methoxybenzaldehyde Synthetic route

: 50-00-0
formaldehyd

: 150-19-6
O-methylresorcine

: 673-22-3
2-Hydroxy-4-methoxybenzaldehyde

Conditions

Conditions	Yield
With triethylamine; magnesium chloride In tetrahydrofuran Inert atmosphere; Reflux;	98%
With triethylamine; magnesium chloride In tetrahydrofuran Inert atmosphere; Reflux; regioselective reaction;	92%
Stage #1: O-methylresorcine With triethylamine; magnesium chloride In acetonitrile at 20℃; for 0.25h; Stage #2: formaldehyd In acetonitrile Reflux;	89%

: 59648-29-2
2-(hydroxymethyl)-5-methoxyphenol

: 673-22-3
2-Hydroxy-4-methoxybenzaldehyde

Conditions

Conditions	Yield
With oxygen In ethanol at 20℃; under 760.051 Torr; for 0.316667h; Catalytic behavior; Green chemistry;	98%
With dihydrogen peroxide at 20℃; for 3.5h; Catalytic behavior; Green chemistry;	98%
With air; (acryl-TEMPO)-co-(allylamine-treated chlorophyll b-Co(III) complex) immobilized on SiO2-covered Fe3O4 magnetic nanoparticles In water at 25℃; for 0.333333h;	94%
With oxygen In aq. buffer at 45℃; for 13h; pH=4.5; Reagent/catalyst; Green chemistry;	93 %Chromat.

: 954374-77-7
ethyl (E)-3-(2-formyl-5-methoxyphenoxy)acrylate

: 2298-07-9
4-Bromo-1-naphthylamine

A: 673-22-3
2-Hydroxy-4-methoxybenzaldehyde

B: C33H32NO8Br

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane at 20℃;	A n/a B 95%

: 954374-77-7
ethyl (E)-3-(2-formyl-5-methoxyphenoxy)acrylate

: 106-49-0
p-toluidine

A: 673-22-3
2-Hydroxy-4-methoxybenzaldehyde

B: 954374-93-7
C30H33NO8

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane at 20℃;	A n/a B 95%

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 673-22-3
2-Hydroxy-4-methoxybenzaldehyde

Conditions

Conditions	Yield
With aluminum (III) chloride In dichloromethane at -5 - 25℃;	94%
With boron trichloride Ambient temperature;	93%
With boron trichloride In dichloromethane at 0 - 20℃; for 16h; Dealkylation;	93%

: 50-00-0
formaldehyd

: 150-19-6
O-methylresorcine

A: 673-22-3
2-Hydroxy-4-methoxybenzaldehyde

B: 700-44-7
6-methoxysalicylaldehyde

Conditions

Conditions	Yield
With triethylamine; magnesium chloride In acetonitrile for 2h; Heating;	A 91% B 5%
With triethylamine; magnesium chloride

: 64-18-6
formic acid

: 41046-70-2
2-iodo-5-methoxyphenol

: 673-22-3
2-Hydroxy-4-methoxybenzaldehyde

Conditions

Conditions	Yield
Stage #1: 2-iodo-5-methoxyphenol With iodine; triethylamine; triphenylphosphine In dichloromethane; toluene at 20℃; for 0.0833333h; Sealed tube; Green chemistry; Stage #2: formic acid In dichloromethane; toluene at 70℃; for 1.5h; Sealed tube; Green chemistry;	91%

: 20503-09-7
2-(2-hydroxy-4-methoxyphenyl)acetic acid

: 673-22-3
2-Hydroxy-4-methoxybenzaldehyde

Conditions

Conditions	Yield
With benzyltriphenylphosphonium peroxodisulfate In acetonitrile for 0.5h; Oxidation; decarboxylation; Heating;	90%

: 954374-77-7
ethyl (E)-3-(2-formyl-5-methoxyphenoxy)acrylate

: 108-42-9
3-chloro-aniline

A: 673-22-3
2-Hydroxy-4-methoxybenzaldehyde

B: C29H30ClNO8

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane at 20℃;	A n/a B 90%

: 954374-77-7
ethyl (E)-3-(2-formyl-5-methoxyphenoxy)acrylate

: 75-31-0
isopropylamine

A: 673-22-3
2-Hydroxy-4-methoxybenzaldehyde

B: C26H33NO8

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane at 20℃;	A n/a B 89%

2-Hydroxy-4-methoxybenzaldehyde Chemical Properties

Product Name: Benzaldehyde,2-hydroxy-4-methoxy- (CAS NO.673-22-3)
IUPAC Name: 2-hydroxy-4-methoxybenzaldehyde

Molecular Formula: C₈H₈O₃
Formula Weight: 152.15
MP: 41-43 °C(lit.)
Density: 1.231 g/cm³
Boiling Point: 271.5 °C at 760 mmHg
Flash Point: 112.1 °C
Vapour Pressure: 0.00387 mmHg at 25°C
Index of Refraction: 1.587
Sensitive : Air Sensitive
Physical State: Solid
Color: slightly beige
Product Categories: FINE Chemical & INTERMEDIATES; Aromatic Aldehydes & Derivatives (substituted); Benzaldehyde

2-Hydroxy-4-methoxybenzaldehyde Uses

Benzaldehyde,2-hydroxy-4-methoxy- (CAS NO.673-22-3) is used as pharmaceutical intermediate.

2-Hydroxy-4-methoxybenzaldehyde Toxicity Data With Reference

sce-hmn:lyms 500 µmol/L

MUREAV Mutation Research. 206 (1988),17.

2-Hydroxy-4-methoxybenzaldehyde Consensus Reports

Reported in EPA TSCA Inventory.

2-Hydroxy-4-methoxybenzaldehyde Safety Profile

Safety: CAUTION: May irritate eyes, skin, and respiratory tract
Hazard Codes : Xi (Irritant)
Risk Statements : 36/37/38 (Irritating to eyes, respiratory system and skin)
Safety Statements : 26-36-24/25 (In case of contact with eyes, rinse immediately with plenty of water and seek medical advice; Wear suitable protective clothing; Avoid contact with skin and eyes)
WGK Germany : 3
RTECS : BZ2810000
F : 10 (Keep under argon)
Hazard Note : Irritant
HS Code : 29124900
Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating vapors.

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