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2-Methylbenzimidazole

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2-Methylbenzimidazole

EINECS 210-411-9
CAS No. 615-15-6 Density 1.186 g/cm3
PSA 28.68000 LogP 1.87130
Solubility slightly soluble in water Melting Point 175-177 °C(lit.)
Formula C8H8N2 Boiling Point 339.4 °C at 760 mmHg
Molecular Weight 132.165 Flash Point 184.5 °C
Transport Information N/A Appearance light beige to brown crystalline powder
Safety 26-39 Risk Codes 22-37/38-41-20/21/22
Molecular Structure Molecular Structure of 615-15-6 (2-Methylbenzimidazole) Hazard Symbols HarmfulXn
Synonyms

Benzimidazole,2-methyl- (8CI);2-Methyl-1H-benzimidazole;2-Methylbenzoimidazole;NSC 6500;

Article Data 335

2-Methylbenzimidazole Chemical Properties

IUPAC Name: 2-methyl-1H-benzimidazole
Synonyms:2-Methyl-1h-Benzo[D]Imidazole;2-Methyl-1h-Benzimidazole;2-Methylbenzimidazole;Akos 90363;Rarechem Aq Nn 0067;1h-2-Methylbenzimidazol;1h-2-Methylbenzimidazole;2-Methyl-1h-Benzimidazol
CAS: 615-15-6
MF: C8H8N2
Molecular Weight of 2-methyl-1H-benzimidazole (615-15-6): 132.16
EINECS: 210-411-9
Product Categories: Benzimdazole;Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines;Benzimidazoles;Building Blocks;Heterocyclic Building Blocks
Mol File: 615-15-6.mol
Melting point:175-177 °C(lit.)
Boiling Point: 339.4 °C at 760 mmHg 
Flash Point: 184.5 °C(lit.)
Vapour Pressure: 0.000181 mmHg at 25°C
Index of Refraction: 1.666
Molar Refractivity: 41.44 cm3 
Molar Volume: 111.3 cm3
Polarizability: 16.42 10-24cm3 
Surface Tension of 2-methyl-1H-benzimidazole (615-15-6): 54.4 dyne/cm 
Density: 1.186 g/cm3 
Enthalpy of Vaporization: 55.98 kJ/mol 
Water Solubility of 2-methyl-1H-benzimidazole (615-15-6):slightly soluble
BRN:112264
CAS DataBase Reference:615-15-6(CAS DataBase Reference)
NIST Chemistry Reference:615-15-6(NIST)                                                                                                                                     EPA Substance Registry System:615-15-6(EPA Substance)

2-Methylbenzimidazole Uses

2-methyl-1H-benzimidazole (615-15-6) can be used in pharmaceutical intermediate .

2-Methylbenzimidazole Toxicity Data With Reference

1.    

mmo-sat 250 µg/plate

    CHIMAD    Chimia. 27 (1973),68.
2.    

mma-sat 500 nmol/plate

    JMCMAR    Journal of Medicinal Chemistry. 22 (1979),981.
3.    

orl-rat LDLo:500 mg/kg

    NCNSA6    National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. 5 (1953),22.
4.    

ivn-mus LD50:200 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 105 (1952),486.


Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 200mg/kg (200mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 105, Pg. 486, 1952.
 
rat LDLo oral 500mg/kg (500mg/kg)   National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 22, 1953.

RTECS#: CAS# 615-15-6: DD9100000
LD50/LC50: RTECS: Not available. 
Carcinogenicity: 2-Methylbenzimidazole - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
Other: The toxicological properties have not been fully investigated. See actual entry in RTECS for complete information
 

2-Methylbenzimidazole Consensus Reports

Reported in EPA TSCA Inventory.

2-Methylbenzimidazole Safety Profile

Poison by intravenous route. Moderately toxic by ingestion. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.Hazard Codes:Xn
Risk Statements:22-37/38-41-20/21/22
Safety Statements:26-39
WGK Germany:3
RTECS:DD9100000
HS Code:29339990

 

2-Methylbenzimidazole Specification

The Molecular Structure of 2-methyl-1H-benzimidazole (615-15-6) is  2-methyl-1H-benzimidazole (615-15-6) is stable under normal temperatures and pressures. 
Avoid incompatible materials to contact 2-methyl-1H-benzimidazole (615-15-6).It is incompatibilities with Other Materials Strong oxidizing agents. 
Hazardous Decomposition Products Carbon monoxide, oxides of nitrogen, carbon dioxide. 
Hazardous Polymerization Will not occur.
2-methyl-1H-benzimidazole (615-15-6) may cause eye irritation and skin irritation. It may be harmful if absorbed through the skin. 
It is harmful if swallowed. May cause irritation of the digestive tract respiratory tract irritation. May be harmful if inhaled.
If you are not careful and contact 2-methyl-1H-benzimidazole (615-15-6) in your eyes,then flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids.If serious, get medical aid. 
If it is in skin,then flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.If necessary,get medical aid. Wash mouth out with water. 
You should remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. 
Avoid breathing dust, vapor, mist, or gas. Do not get on skin and clothing. 
2-methyl-1H-benzimidazole (615-15-6) must be stored in a cool, dry place. Store in a tightly closed container. 
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. 
Use water spray, dry chemical, carbon dioxide, or chemical foam in a Extinguishing Media.                       
 

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