Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

2H-1,2,4-Benzothiadiazine-7-sulfonamide,3,4-dihydro-6-(trifluoromethyl)-, 1,1-dioxide

Related Products

Hot Products

Basic Information Post buying leads Suppliers
Name

2H-1,2,4-Benzothiadiazine-7-sulfonamide,3,4-dihydro-6-(trifluoromethyl)-, 1,1-dioxide

EINECS 205-173-8
CAS No. 135-09-1 Density 1.678 g/cm3
PSA 135.12000 LogP 3.34280
Solubility 329.9mg/L(room temperature) Melting Point 272-273oC
Formula C8H8F3N3O4S2 Boiling Point 531.6 °C at 760 mmHg
Molecular Weight 331.296 Flash Point 275.3 °C
Transport Information N/A Appearance N/A
Safety 36 Risk Codes 42/43
Molecular Structure Molecular Structure of 135-09-1 (HYDROFLUMETHIAZIDE) Hazard Symbols HarmfulXn;IrritantXi
Synonyms

Hydroflumethiazide;

 

2H-1,2,4-Benzothiadiazine-7-sulfonamide,3,4-dihydro-6-(trifluoromethyl)-, 1,1-dioxide Specification

The 2H-1,2,4-Benzothiadiazine-7-sulfonamide,3,4-dihydro-6-(trifluoromethyl)-, 1,1-dioxide, with the CAS registry number of 135-09-1, is also known as Hydroflumethiazide. Its EINECS registry number is 205-173-8. This chemical's molecular formula is C8H8F3N3O4S2 and molecular weight is 331.29. What's more, its IUPAC name is 1,1-Dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide. This chemical's classification codes are Antihypertensive, Antihypertensive agents, Cardiovascular Agents, Diuretic, Diuretics, Drug / Therapeutic Agent. It is a thiazide diuretic with actions and uses similar to those of Hydrochlorothiazide.

Physical properties about the 2H-1,2,4-Benzothiadiazine-7-sulfonamide,3,4-dihydro-6-(trifluoromethyl)-, 1,1-dioxide are: (1)ACD/LogP: 0.36; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.36; (4)ACD/LogD (pH 7.4): 0.33; (5)ACD/BCF (pH 5.5): 1.1; (6)ACD/BCF (pH 7.4): 1.04; (7)ACD/KOC (pH 5.5): 37.37; (8)ACD/KOC (pH 7.4): 35.1; (9)#H bond acceptors: 7; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 94.76 Å2; (13)Index of Refraction: 1.55; (14)Molar Refractivity: 62.88 cm3; (15)Molar Volume: 197.3 cm3; (16)Surface Tension: 47.5 dyne/cm; (17)Density: 1.678 g/cm3; (18)Flash Point: 275.3 °C; (19)Enthalpy of Vaporization: 80.72 kJ/mol; (20)Boiling Point: 531.6 °C at 760 mmHg; (21)Vapour Pressure: 2.2E-11 mmHg at 25 °C.

When you are using this chemical, please be cautious about it as the following:
It may cause sensitisation by inhalation and skin contact. In addition, during using it, wear suitable protective clothing.

You can still convert the following datas into molecular structure:
(1) SMILES: FC(F)(F)c2c(cc1c(NCNS1(=O)=O)c2)S(=O)(=O)N
(2) InChI: InChI=1/C8H8F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-2,13-14H,3H2,(H2,12,15,16)
(3) InChIKey: DMDGGSIALPNSEE-UHFFFAOYAE

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 6280mg/kg (6280mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of Pharmacology and Experimental Therapeutics. Vol. 134, Pg. 273, 1961.
Link to PubMed
mouse LD50 intravenous 750mg/kg (750mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 134, Pg. 273, 1961.
Link to PubMed
mouse LD50 oral > 10gm/kg (10000mg/kg)   Drugs in Japan Vol. 6, Pg. 629, 1982.
mouse LD50 parenteral 1182mg/kg (1182mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD French Medicament Patent Document. Vol. #80M,

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 135-09-1