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Name |
3-Chloro-4-fluoroaniline |
EINECS | 206-682-8 |
CAS No. | 367-21-5 | Density | 1.349 g/cm3 |
PSA | 26.02000 | LogP | 2.64250 |
Solubility | 10 g/L (20 °C) in water | Melting Point |
42-44 °C(lit.) |
Formula | C6H5ClFN | Boiling Point | 227.5 °C at 760 mmHg |
Molecular Weight | 145.564 | Flash Point | 99.4 °C |
Transport Information | UN 2811 6.1/PG 2 | Appearance | dark purple to black solid |
Safety | 36/37/39-45-26 | Risk Codes | 23/24/25-33-36/37/38-20/21/22 |
Molecular Structure | Hazard Symbols | T, Xn, Xi | |
Synonyms |
Benzenamine, 3-chloro-4-fluoro-;3-chloro-4-fluoro-aniline;Aniline, 3-chloro-4-fluoro-;3-Chloro-4-fluoro-phenylamine; |
Article Data | 35 |
Conditions | Yield |
---|---|
With hydrogen In ethanol; water at 25℃; under 760.051 Torr; for 3h; Autoclave; | 99.9% |
With sodium tetrahydroborate; cyclohexanediamine-Pd-β-cyclodextrin In water at 20℃; for 3h; Sealed tube; | 96% |
With hydrazine hydrate In ethanol at 100℃; under 760.051 Torr; for 8h; Time; Sealed tube; chemoselective reaction; | 94.7% |
3-chloro-4-fluorophenylamine
Conditions | Yield |
---|---|
With methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate at 20℃; for 0.25h; chemoselective reaction; | 86% |
(3-chloro-4-fluoro-phenyl)-carbamic acid tert-butyl ester
3-chloro-4-fluorophenylamine
Conditions | Yield |
---|---|
With methanol; oxalyl dichloride at 20℃; for 2h; | 80% |
Conditions | Yield |
---|---|
With Piperonyl butoxide; hydrogen fluoride Yields of byproduct given; | A 34% B n/a |
3-chloro-4-fluorophenylamine
Conditions | Yield |
---|---|
(i) PCl5, (ii) aq. HCl; Multistep reaction; |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: iron-powder / Einleiten von Chlor 2: titanium (III)-chloride; water View Scheme | |
Multi-step reaction with 2 steps 1: Cl2, FeCl3 2: Fe, aq. NH4Cl View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrogenchloride; sodium nitrite / water / 0.5 h 2: trifluoromethan; fluorosulfonyl fluoride / 70 °C 3: hydrogenchloride / water / 2 h / 50 °C View Scheme |
3-chloro-4-fluorophenylamine
Conditions | Yield |
---|---|
With hydrogenchloride In water at 50℃; for 2h; |
3-chloro-4-fluorophenylamine
diethyl 2-ethoxymethylenemalonate
diethyl 2-[(3-chloro-4-fluorophenylamino)methylene]malonate
Conditions | Yield |
---|---|
at 120 - 130℃; for 2h; | 100% |
for 0.0333333h; Gould-Jacob reaction; Irradiation; | 99% |
at 110℃; for 1h; Microwave irradiation; | 99% |
3-chloro-4-fluorophenylamine
di-tert-butyl dicarbonate
(3-chloro-4-fluoro-phenyl)-carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Stage #1: 3-chloro-4-fluorophenylamine With triethylamine In tetrahydrofuran; water at 20℃; for 0.0833333h; Stage #2: di-tert-butyl dicarbonate In tetrahydrofuran; water at 0 - 20℃; for 6h; | 100% |
With 1-butyl-3-methylimidazolium trifluoromethanesulfonimide at 30 - 35℃; for 0.25h; neat (no solvent); chemoselective reaction; | 95% |
In water at 30 - 35℃; for 6h; | 92% |
Molecular Structure:
Molecular Formula: C6H5ClFN
Molecular Weight: 145.562
IUPAC Name: 3-Chloro-4-fluoroaniline
Synonyms of 3-Chloro-4-fluoroaniline (CAS NO.367-21-5): Aniline, 3-chloro-4-fluoro- ; EINECS 206-682-8 ; NSC 10290 ; Benzenamine, 3-chloro-4-fluoro-
CAS NO: 367-21-5
Product Categories: Drug Intermediates ; Anilines, Aromatic Amines and Nitro Compounds ; Fluorobenzene ; C2 to C6 ; Nitrogen Compounds ; ChloroChemical Class ; FluoroMore...Close... ; Alpha Sort ; Amines ; Analytical Standards ; AromaticsChemical Class ; AromaticsVolatiles/ Semivolatiles ; C ; CAlphabetic ; CHChemical Class ; Chemical Class ; Halogenated ; Aniline series
Melting point: 42-44 °C
Index of Refraction: 1.569
Molar Refractivity: 35.37 cm3
Molar Volume: 107.8 cm3
Surface Tension: 42.9 dyne/cm
Density: 1.349 g/cm3
Flash Point: 99.4 °C
Enthalpy of Vaporization: 46.41 kJ/mol
Boiling Point: 227.5 °C at 760 mmHg
Vapour Pressure: 0.0773 mmHg at 25°C
3-Chloro-4-fluoroaniline (CAS NO.367-21-5) is used as the important intermediates for Norfloxacin Synthesis.
Safety Information about 3-Chloro-4-fluoroaniline (CAS NO.367-21-5):
Hazard Codes: T,Xi,Xn
Risk Statements:
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed
R33: Danger of cumulative effects
R36/37/38: Irritating to eyes, respiratory system and skin
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed
Safety Statements:
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45:I n case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 2811 6.1/PG 2