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3-Fluorobenzyl chloride

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Name

3-Fluorobenzyl chloride

EINECS 207-264-8
CAS No. 456-42-8 Density 1.191 g/cm3
PSA 0.00000 LogP 2.56450
Solubility 40 g/L (20 °C) in water Melting Point 34.5-36 °C
Formula C7H6ClF Boiling Point 173.3 °C at 760 mmHg
Molecular Weight 144.576 Flash Point 58.9 °C
Transport Information N/A Appearance Colorless to light yellow liquid
Safety 26-36/37/39-45 Risk Codes 34-37
Molecular Structure Molecular Structure of 456-42-8 (3-Fluorobenzyl chloride) Hazard Symbols CorrosiveC
Synonyms

a-Chloro-m-fluorotoluene;Toluene,a-chloro-m-fluoro- (6CI,7CI,8CI);1-(Chloromethyl)-3-fluorobenzene;3-Fluorophenylmethylchloride;NSC 60720;m-Fluorobenzyl chloride;a-Chloro-3-fluorotoluene;

Article Data 27

3-Fluorobenzyl chloride Synthetic route

352-70-5

m-Fluorotoluene

456-42-8

m-fluorobenzyl chloride

Conditions
ConditionsYield
With methanol; tetrachloromethane; iron(II) chloride tetrahydrate; formamide at 180℃; for 6h; Reagent/catalyst; Inert atmosphere; Sealed tube; Autoclave; chemoselective reaction;35%
at 147℃; Irradiation.Einleiten von Chlor;
at 147℃; Einleiten von Chlor;
352-70-5

m-Fluorotoluene

A

402-64-2

1-dichloromethyl-3-fluoro-benzene

B

456-42-8

m-fluorobenzyl chloride

Conditions
ConditionsYield
Chlorierung;
456-47-3

3-fluoro-benzenemethanol

456-42-8

m-fluorobenzyl chloride

Conditions
ConditionsYield
With pyridine; thionyl chloride
28490-56-4

1-fluoro-3-(iodomethyl)benzene

456-42-8

m-fluorobenzyl chloride

Conditions
ConditionsYield
With pyridine; tributyltin chloride at 50℃; Thermodynamic data; Equilibrium constant; Δ G;28 % Spectr.
65108-06-7

m-fluorobenzyl ion

456-42-8

m-fluorobenzyl chloride

Conditions
ConditionsYield
With tertiary butyl chloride In gaseous matrix at 600℃; chloride affinity;
456-41-7

1-(Bromomethyl)-3-fluorobenzene

456-42-8

m-fluorobenzyl chloride

Conditions
ConditionsYield
With pyridine; tributyltin chloride at 50℃; Thermodynamic data; Equilibrium constant; Δ G;65 % Spectr.
100-11-8

1-bromomethyl-4-nitro-benzene

456-42-8

m-fluorobenzyl chloride

Conditions
ConditionsYield
With pyridine; tributyltin chloride at 50℃; Thermodynamic data; Equilibrium constant; Δ G;65 % Spectr.
394-54-7

1-(1-chloro-2,2,2-trifluoroethyl)-4-chlorobenzene

65108-06-7

m-fluorobenzyl ion

A

128408-33-3

C8H5ClF3(1+)

B

456-42-8

m-fluorobenzyl chloride

Conditions
ConditionsYield
at 69.85℃; Thermodynamic data; chloride-transfer;
191402-55-8

1-(1-Chloro-2,2,2-trifluoro-ethyl)-3-methyl-benzene

65108-06-7

m-fluorobenzyl ion

A

128408-28-6

C9H8F3(1+)

B

456-42-8

m-fluorobenzyl chloride

Conditions
ConditionsYield
at 69.85℃; Thermodynamic data; chloride-transfer;
81577-13-1

1-(1-Chloro-2,2,2-trifluoro-ethyl)-4-fluoro-benzene

65108-06-7

m-fluorobenzyl ion

A

128408-32-2

C8H5F4(1+)

B

456-42-8

m-fluorobenzyl chloride

Conditions
ConditionsYield
at 69.85℃; Thermodynamic data; chloride-transfer;

3-Fluorobenzyl chloride Chemical Properties

Molecular Formula  m-Fluorobenzyl chloride(456-42-8) : C7H6ClF
Formula Weight m-Fluorobenzyl chloride(456-42-8) : 144.57
Molecular Structure:
Boiling point: 176-177 °C
density : 1.194 g/mL at 25 °C(lit.)
refractive index : n20/D 1.511(lit.)
Flash point : 138 °F
WATER Solubility of m-Fluorobenzyl chloride: 40 g/L (20 °C)

3-Fluorobenzyl chloride Uses

M-Fluorobenzyl chloride(456-42-8)  is For R&D use only. 

3-Fluorobenzyl chloride Toxicity Data With Reference

ACUTE EFFECTS:
Corrosive
May be harmful by ingestion and inhalation.
Material is irritating to mucous membranes and upper respiratory tract.
To the best of our knowledge, the toxicological properties of m-Fluorobenzyl chloride have not been fully determined.

3-Fluorobenzyl chloride Safety Profile

The Hazard Codes  of m-Fluorobenzyl chloride (456-42-8)  :  C
The Risk Statements information of  m-Fluorobenzyl chloride (456-42-8) :
34:  Causes burns 
37:  Irritating to the respiratory system 
The Safety Statements information of  m-Fluorobenzyl chloride(456-42-8) :
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) 
36/37/39:  Wear suitable protective clothing, gloves and eye/face protection 
RIDADR : UN 2920 8/PG 2
WGK Germany : 3
Hazard Note : Corrosive/Lachrymatory
Hazard Class : 3
Packing Group : III
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