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Cas Database |
| Name |
3-Hydroxy-2,4,5-trifluorobenzoicacid |
EINECS | N/A |
| CAS No. | 116751-24-7 | Density | 1.699 g/cm3 |
| PSA | 57.53000 | LogP | 1.50770 |
| Solubility | N/A | Melting Point |
144-145 °C |
| Formula | C7H3F3O3 | Boiling Point | 292.6 °C at 760 mmHg |
| Molecular Weight | 192.094 | Flash Point | 130.8 °C |
| Transport Information | N/A | Appearance | white to light yellow-beige powder |
| Safety | 26-37/39 | Risk Codes | 36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
 Xi
|
| Synonyms |
2,4,5-Trifluoro-3-hydroxybenzoic acid;2,4,5-Trifluoro-3-hydroxybenzoicacid; |
Article Data | 7 |
3-Hydroxy-2,4,5-trifluorobenzoicacid Synthetic route
- 652-03-9
3,4,5,6-tetrafluorophthalic acid
- 116751-24-7
2,4,5-trifluoro-3-hydroxybenzoic acid
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 3,4,5,6-tetrafluorophthalic acid With sodium hydroxide In water at 90℃; for 9h; Stage #2: With hydrogenchloride; tri-n-propylamine In water at 140℃; under 7500.75 Torr; for 7h; pH=1; Temperature; | 90.35% |
- 28749-88-4
3,4,6-trifluoro-5-hydroxyphthalic acid
- 116751-24-7
2,4,5-trifluoro-3-hydroxybenzoic acid
Conditions
| Conditions | Yield |
|---|---|
| In water | 90% |
| In water | 90% |
- 28889-41-0
4-methoxy-3,5,6-trifluorophthalic acid
- 116751-24-7
2,4,5-trifluoro-3-hydroxybenzoic acid
Conditions
| Conditions | Yield |
|---|---|
| In water | 74% |
| In water | 74% |
- 116751-24-7
2,4,5-trifluoro-3-hydroxybenzoic acid
Conditions
| Conditions | Yield |
|---|---|
| With sodium hydroxide; zinc In water at 25℃; for 2h; | 1.92 g |
- 124-38-9
carbon dioxide
A
- 116751-24-7
2,4,5-trifluoro-3-hydroxybenzoic acid
B
- 156839-10-0
2,3,5-trifluoro-4-hydroxybenzoic acid
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: triisopropyl(2,3,6-trifluorophenoxy)silane With 2,2,6,6-tetramethylpiperidinyl-lithium In diethyl ether Stage #2: carbon dioxide In diethyl ether Stage #3: With hydrogenchloride Title compound not separated from byproducts; |
- 124-38-9
carbon dioxide
A
- 116751-24-7
2,4,5-trifluoro-3-hydroxybenzoic acid
B
- 156839-10-0
2,3,5-trifluoro-4-hydroxybenzoic acid
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 1,2,4-trifluoro-3-(methoxymethoxy)benzene With n-butyllithium In tetrahydrofuran Stage #2: carbon dioxide In tetrahydrofuran; hexane Stage #3: With hydrogenchloride In water Title compound not separated from byproducts; | |
| Stage #1: 1,2,4-trifluoro-3-(methoxymethoxy)benzene With lithium diisopropyl amide In tetrahydrofuran Stage #2: carbon dioxide In tetrahydrofuran Stage #3: With hydrogenchloride In water Title compound not separated from byproducts; |
- 851341-31-6
1-bromo-2,3,5-trifluoro-4-(methoxymethoxy)benzene
- 116751-24-7
2,4,5-trifluoro-3-hydroxybenzoic acid
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1.1: 2,2,6,6-tetramethylpiperidine; potassium tert-butoxide; N,N,N',N'',N''-pentamethylenediamine / butyllithium / tetrahydrofuran; hexane / 0.75 h / -125 °C 1.2: tetrahydrofuran; hexane 2.1: HCl / H2O 3.1: 1.92 g / NaOH; zinc powder / H2O / 2 h / 25 °C View Scheme |
- 116751-24-7
2,4,5-trifluoro-3-hydroxybenzoic acid
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: HCl / H2O 2: 1.92 g / NaOH; zinc powder / H2O / 2 h / 25 °C View Scheme |
- 113798-74-6
2,3,6-trifluorophenol
- 116751-24-7
2,4,5-trifluoro-3-hydroxybenzoic acid
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1.1: 82 percent / imidazole / dimethylformamide / 20 h / 25 °C 2.1: lithium 2,2,6,6-tetramethylpiperidide / diethyl ether 2.2: diethyl ether 2.3: hydrochloric acid View Scheme | |
| Multi-step reaction with 5 steps 1.1: 87 percent / N-bromosuccinimide / CHCl3 / 2 h / 0 °C 2.1: 88 percent / N-ethyldiisopropylamine / CH2Cl2 / 2 h / 25 °C 3.1: 2,2,6,6-tetramethylpiperidine; potassium tert-butoxide; N,N,N',N'',N''-pentamethylenediamine / butyllithium / tetrahydrofuran; hexane / 0.75 h / -125 °C 3.2: tetrahydrofuran; hexane 4.1: HCl / H2O 5.1: 1.92 g / NaOH; zinc powder / H2O / 2 h / 25 °C View Scheme | |
| Multi-step reaction with 2 steps 1.1: 87 percent / N-ethyldiisopropylamine / CH2Cl2 / 25 °C 2.1: lithium diisopropylamide / tetrahydrofuran 2.2: tetrahydrofuran 2.3: HCl / H2O View Scheme |
- 192446-70-1
4-bromo-2,3,6-trifluorophenol
- 116751-24-7
2,4,5-trifluoro-3-hydroxybenzoic acid
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1.1: 88 percent / N-ethyldiisopropylamine / CH2Cl2 / 2 h / 25 °C 2.1: 2,2,6,6-tetramethylpiperidine; potassium tert-butoxide; N,N,N',N'',N''-pentamethylenediamine / butyllithium / tetrahydrofuran; hexane / 0.75 h / -125 °C 2.2: tetrahydrofuran; hexane 3.1: HCl / H2O 4.1: 1.92 g / NaOH; zinc powder / H2O / 2 h / 25 °C View Scheme |
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3-Hydroxy-2,4,5-trifluorobenzoic acid
